@article{Delis_Linardatou_Karatzanos_Kourek_Philippou_Vagionas_Panagopoulou_Alshamari_Pittaras_Nanas_Vasileiadis_2022, title={Addition of strength training modifies the aerobic exercise inflammatory response in heart failure patients – Comments on the underlying pathophysiology}, volume={8}, url={https://ejournals.epublishing.ekt.gr/index.php/HealthResJ/article/view/29806}, DOI={10.12681/healthresj.29806}, abstractNote={<p><strong>Aim: </strong>The present study investigates the effect of Strength Training addition in a High Intensity Interval Training (HIIT) program, on the inflammatory profile of chronic heart failure (CHF) patients.</p> <p><strong>Materials and Methods:</strong> Forty-six CHF patients were randomized into the two different exercise rehabilitation groups. A patient group (control) performed HIIT and another group performed Combined (HIIT and strength training) Exercise Training (COM) for a three- month period. Before and after rehabilitation, all patients performed a maximal cardiopulmonary exercise testing (CPET). Microcirculatory parameters were assessed by Near Infrared Spectroscopy; CRP, IL-2, IL-6, IL-10 and VEGF levels were measured in plasma.</p> <p><strong>Results:</strong> Cardiopulmonary parameters and microcirculatory indices improved after rehabilitation. CRP and the IL-6/IL-10 ratio decreased after rehabilitation. By linear regression analysis, a negative correlation was noted between IL-2, IL-6 and IL-10 changes (post-CPET values) and the VE/VCO<sub>2</sub> slope change, for the entire patient cohort. The correlation was separately maintained only in the COM group.</p> <p><strong>Conclusions:</strong> Overall, the results of the present study reinforce the view of an anti-inflammatory effect of exercise in CHF patients. The significant correlations demonstrated between the cytokine responses and the ventilatory response to exercise, particularly in the COM group, probably ensue from the special effect of strength training on peripheral muscle function.</p>}, number={2}, journal={Health & Research Journal}, author={Delis, Dimitrios and Linardatou, Vasiliki and Karatzanos, Eleftherios and Kourek, Chris and Philippou, Anastasios and Vagionas, Dimitrios and Panagopoulou, Niki and Alshamari, Manal and Pittaras, Theodoros and Nanas, Serafim and Vasileiadis, Ioannis}, year={2022}, month={Apr.}, pages={146–161} }