TY - JOUR AU - Mallisova, Evagelia AU - Dokoutsidou, Helen AU - Kalogianni, Antonia AU - Vasilopoulos, Georgios PY - 2019/02/07 Y2 - 2024/03/29 TI - Outcome after Intravenous Thhrombolysis in patients with Acute Ischemic Stroke JF - Health & Research Journal JA - HRJ VL - 4 IS - 1 SE - Reviews DO - 10.12681/healthresj.19633 UR - https://ejournals.epublishing.ekt.gr/index.php/HealthResJ/article/view/19633 SP - 4-20 AB - <div class="page" title="Page 2"><table><tbody><tr><td> </td></tr><tr><td><div class="layoutArea"><div class="column"><p><span>Introduction: </span><span>Vascular disorders represent a major cause of mortality worldwide, with ischemic stroke to be the second cause of mortality, after coronary artery disease.<br /> </span><span>Aim: </span><span>The aim of the present review was to investigate the contribution of thrombolysis in the outcome of patients with ischemic stroke. </span></p><p><span>Material and Method: </span><span>This is a systemic review of the literature. The sources of the literature were the databases EBSCO HOST, Elsevier Science Direct, PubMed, Medline, CINAHL, and Google Scholar.No time limit was set. The </span></p></div></div></td></tr><tr><td><div class="layoutArea"><div class="column"><p><span>following keywords were used: ischemic stroke, thrombolysis, infarction, outcome, time window, side effects, benefits, alteplase, etiology, diagnosis, treatment.<br /> </span><span>Results: </span><span>Three multicenter studies were found to meet the inclusion criteria, the NINDS trial, the ECASS II and the STARS. Thrombolysis in ischemic stroke has been associated with a significantly lower mortality, fewer intracranial hemorrhages and improved neurological outcome when administered in less than 3 hours. </span></p><p><span>Conclusions: </span><span>The therapeutic benefits of alteplase reduced with time, while it has been determined that after 4.5 hours from the onset of symptoms of ischemic stroke has a significant benefit. </span></p></div></div></td></tr><tr><td> </td></tr></tbody></table></div> ER -