Effects of concomitant selenium and vitamin E administration on thyroid hormone metabolism in broilers


Published: Jan 29, 2018
Keywords:
Broiler glutathione peroxidase selenium type I iodothyronine deiodinase vitamin E
A. C. PAPPAS
B. M. KOTSAMPASI
K. KALAMARAS
K. FEGEROS
G. ZERVAS
D. KALOGIANNIS
S. E. CHADIO
Abstract

A total of 400, as hatched, broilers were used to investigate the effect of selenium (Se) and vitamin E supplementation on thyroid hormones metabolism. There were 5 replicates of 4 dietary treatments namely: control (C), a soybean meal maize basal diet with adequate Se and vitamin E (0.3 mg Se per kg diet and 80 mg vitamin E per kg diet), control diet with Se added (Se+, with an additional 1 mg of Se per kg of diet), control diet with vitamin E added (E+, with an additional 350 mg of vitamin E per kg of diet) and Se+E+ (with additional 1 mg of Se and 350 mg of vitamin E per kg of diet). Diets were isonitrogenous and isocaloric. Zinc L-selenomethionine complex was used to increase Se content and dl-α-tocopheryl acetate to increase vitamin E content. The experiment lasted 42 days. Plasma Se concentration increased in Se+ groups, while whole blood glutathione peroxidase (GPx) activity increased in Se+, E+ and Se+E+ groups compared to control. Hepatic type I iodothyronine deiodinase (ID-I) and thyroid hormone concentrations were unaffected by any dietary treatment. It is concluded that supplementation with Se or vitamin Ε alone or in combination above animal’s requirements does not affect thyroid hormone metabolism and liver ID-I activity under the conditions examined.

Article Details
  • Section
  • Research Articles
Downloads
Download data is not yet available.
References
Basmacıoğlu Malayoğlu H, Özkan S, Koçtürk S, Oktay G, Ergül M (2009) Dietary vitamin E (α-tocopheryl acetate) and organic selenium supplementation: performance and antioxidant status of broilers fed n-3 PUFA-enriched feeds. S Afr J Anim Sci, 39:274-285.
Beckett GJ, Beddows SE, Morris PC, Nicol F, Arthur JR (1987) Inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats. Biochem J, 248:443-447.
Behne D, Kyriakopoulos A, Gessner H, Walzog B, Meinhold H (1992) Type I iodothyronine deiodinase activity after high selenium intake and relations between selenium and iodine metabolism in rat. J Nutr, 122:1542–1546.
Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR (2002) biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev, 23:38-89.
Bradford MM (1976) A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem, 72:248-254.
Brzezińska-Slebodzińska E, Pietras B (1997) The protective role of some antioxidants and scavengers on the free radicals-induced inhibition of the liver iodothyronine 5’-monodeiodinase activity and thiols content. J Physiol Pharmacol, 48:451-459.
Brzezińska-Slebodzińska E (2001) Fever induced oxidative stress. The effect of thyroid status and the 5’-monodeiodinase activity Protective role of selenium and vitamin E. J Physiol Pharmacol, 52:275-284.
Burton GW, Traber MG (1990) Vitamin E:antioxidant activity, biokinetics, and bioavailability. Ann Rev Nutr, 10:357–382.
Chadio SE, Kotsampasi BM, Menegatos JG, Zervas GP, Kalogiannis DG (2006) Effect of selenium supplementation on thyroid hormone levels and selenoenzyme activities in growing lambs. Biol Trace Elem Res, 109:145-154.
Chadio SE, Pappas AC, Papanastasatos A, Pantelia D, Dardamani A, Fegeros K, Zervas G (2015) Effects of high selenium and fat supplementation on growth performance and thyroid hormones concentration of broilers. J Trace Elem Med Biol, 29:202-207.
Chang WP, Combs JFJ, Scanes GG, March JA (2005) The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken. Dev Comp Immunol, 29:265-273.
Chaurasia SS, Gupta P, Kar A, Maiti PK (1996) Free radical mediated membrane perturbation and inhibition of type I iodothyronine 5%-monodeiodinase activity by lead and cadmium in rat liver homogenate. Biochem Mol Biol Int, 39:765–770.
Chaurasia SS, Kar A (1997) Protective effects of vitamin E against leadinduced deterioration of membrane associated type-I iodothyronine 5΄-monodeiodinase (5΄D-I) activity in male mice. Toxicology 124:203–209.
Chaurasia SS, Panda S, Kar A (1997) Lead inhibits type-I iodothyronine 5%-monodeiodinase in the Indian rock pigeon, Columba livia:A possible involvement of essential thiol groups. J Biosci, 22:247–254.
Darras VM, Van der Geyten S, Kühn ER (2000) Thyroid hormone metabolism in poultry. Biotechnol Agron Soc Environ, 4:13–20.
Drutel A, Archambeaud F, Caron P (2013) Selenium and the thyroid gland:more good news for clinicians. Clin Endocrinol, 78:155-164.
Giray B, Kan E, Bali M, Hincal F, Basaran N (2003) The effect of vitamin E supplementation on antioxidant enzyme activities and lipid peroxidation levels in hemodialysis patients. Clin Chim Acta, 338:91-98.
Ip C, Hayes C (1989) Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Carcinogenesis, 10:921-925.
Jianhua H, Ohtsuka A, Hayashi K (2000) Selenium influences growth via thyroid hormone status in broiler chickens. Br J Nutr, 84:727-732.
Kocer-Gumusel B, Erkekoglu P, Caglayan A, Hincal F (2015) The ameliorating effects of vitamin E on hepatic antioxidant system and xenobiotic metabolizing enzymes in fenvalerate-exposed iodinedeficient rats. Drug Chem Toxicol, 8:1-8.
Kohrle J (1999) Local activation and inactivation of thyroid hormones:the deiodinases family. Mol Cell Endocrinol, 151:103-119.
Köhrle J (2013) Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes, 20:441-448.
Maiti PK, Kar A, Gupta P, Chaurasia SS (1995) Loss of membrane integrity and inhibition of type-I iodothyronine 5΄-monodeiodinase activity by fenvalerate in female mouse. Biochem Biophy Res Commun, 214:905–909.
Mancini A, Raimondo S, Di Segni C, Persano M, Gadotti G, Silvestrini A, Festa R, Tiano L, Pontecorvi A, Meucci E (2013) Thyroid hormones and antioxidant systems:focus on oxidative stress in cardiovascular and pulmonary diseases. Int J Mol Sci, 14:23893-23909.
Mitchell JH, Nicol F, Beckett GJ (1996) Selenoenzyme expression in thyroid and liver of second generation selenium-and iodinedeficient rats. J Mol Endocrinol, 16:259-267.
Ozkan S, Malayoğlu HB, Yalçin S, Karadas F, Koçtürk S, Cabuk M, Oktay G, Ozdemir S, Ozdemir E, Ergül M (2007) Dietary vitamin E (α-tocopherol acetate) and selenium supplementation from different sources: performance, ascites-related variables and antioxidant status in broilers reared at low and optimum temperatures. Brit Poultry Sci 48:580-593.
Packer L (1991) Protective role of vitamin E in biological systems. Am J Clin Nutr, 53:1050S–1055S.
Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med, 70:158-169.
Pappas AC, Zoidis E, Georgiou CA, Demiris N, Surai PF, Fegeros K (2011) Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 28:446-454.
Ramos JJ, Fernandez AMT, Verde T, Sanz MC, Marca MC (1998) Effect of inoculation with selenium and / or vitamin E on the immune response of lambs. Med Vet, 15:291-296.
Rooke JA, Robinson JJ, Arthur JR (2004) Effects of vitamin E and selenium on the performance and immune status of ewes and lambs. J Agric Sci, 142:253-262.
Sahin N, Sahin K, Kucuk O (2001) Effects of vitamin E and vitamin A supplementation on performance, thyroid status and serum concentrations of some metabolites and minerals in broilers reared under heat stress (32 oC). Vet Med Czech, 46:286-292.
Sarandöl E, Taş S, Dirican M, Serdar Z (2005) Oxidative stress and serum paraoxonase activity in experimental hypothyroidism:effect of vitamin E supplementation. Cell Biochem Funct 23:1–8.
Sawada K, Hummel BC, Walfish PG (1986) Properties of cytosolic components activating rat hepatic 5´-deiodination in the presence of NADPH. Biochem J, 234:391-398.
Schmutzler C, Mentrup B, Schomburg L, Hoang-Vu C, Herzog V, Köhrle J (2007) Selenoproteins of the thyroid gland:expression,localization and possible function of glutathione peroxidase 3. Biol Chem, 388:1053-1059.
Soliman EB (2015) Dose-response of vitamin E and selenium injection on growth performance, physiological and immune responses of Ossimi lambs. Egypt J Sheep & Goat Sci 10:27-40.
Toyoda N, Berry MJ, Harney JW, Larsen PR (1995) Topological analysis of the integral membrane protein, Type I iodothyronine deiodinase (D1). J Biol Chem, 270:12310–12318.
Traş B, Inal F, Baş AL, Altunok V, Elmas M, Yazar E (2000) Effects of continuous supplementations of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens. Brit Poultry Sci, 41:664-666.
Villanueva I, Alva-Sánchez C, Pacheco-Rosado J (2013) The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration Oxidative medicine and cellular longevity. Article ID 218145, http://dxdoiorg/101155/2013/218145.
Venditti P, Di Stefano L, Di Meo S (2013) Vitamin E management of oxidative damage-linked dysfunctions of hyperthyroid tissues. Cell Mol Life Sci, 70:3125–3144.
Venditti P, Napolitano G, Di Stefano L, Chiellini G, Zucchi R, Scanlan TS, Di Meo S (2011) Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity. Mol Cell Endocrinol, 341:55–62.
Whanger PD, Butler JA (1988) Effects of various dietary levels of selenium as selenite or selenomethionine on tissue selenium levels and glutathione peroxidase activity in rats. J Nutr, 118:846-852.
Yue L, Wang F, Li G (1998) Changes of peripheral tissue thyroid hormone metabolism in rats fed with selenium- and vitamin E-deficient artificial semisynthetic diet. Chin Med J (Engl), 111:854-857.
Most read articles by the same author(s)