Comparison of Lidocaine-Xylazine and Procaine-Xylazine for Lumbar Epidural Anesthesia in Cattle

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DOI: https://doi.org/10.12681/jhvms.21802
Keywords:
Cow epidural anesthesia lidocaine procaine xylazine
R. SATO
Laboratory of Farm Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Japan
E. KANAI
Laboratory of Veterinary Radiology, School of Veterinary Medicine, Azabu University, Japan
A. TSUKAMOTO
Laboratory of Laboratory Animal Science, School of Veterinary Medicine, Azabu University, Japan
Abstract

Lumbar epidural anesthesia is commonly utilized in veterinary medicine for diagnostic, obstetrical, and surgical intervention in the abdominal and perineal regions of large animals. The aim of this study was to directly compare the time to onset and duration of epidural anesthesia produced by lidocaine-xylazine and procaine-xylazine combinations to that produced by xylazine alone in cattle. A total of 24 healthy adult Holstein dairy cows were included in this study. The time to onset and duration of anesthesia were recorded. The heart rate, respiratory rate, and rectal temperature were recorded at 0 minute and at 10, 20, 30, 60, and 90 minutes after the epidural administration of each treatment. The time to onset of anesthesia did not significantly differ between the xylazine only group and the lidocaine-xylazine and procaine-xylazine combination groups. The duration of anesthesia in the xylazine only group was significantly shorter than that in the lidocaine-xylazine and procaine-xylazine combination groups (p < 0.05). Ataxia was not observed in any group. The heart rate, respiratory rate, and rectal temperature values in all the treatment groups throughout the study did not significantly differ from those at baseline. We found that administration of procaine hydrochloride in combination with xylazine hydrochloride, an α2-adrenergic receptor agonist, offers the same time to onset and duration of anesthesia as does epidural anesthesia using a combination of lidocaine hydrochloride and xylazine hydrochloride. Furthermore, this combination of treatments did not cause adverse effects in the cardiovascular and respiratory systems. These findings indicate that combined administration of procaine and xylazine is an economic and useful approach for epidural anesthesia.

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References
Day TK, Skarda RT (1991) The pharmacology of local anesthetics. Vet Clin North Am Equine Pract 7:489-500.
Eisenach JC, Decock M, Klim S (1996) Alpha-2 adrenergic agonists for regional anesthesia: a clinical review of clonidine. Anesthesiology 85:655-674.
Elmore RG (1980) Food-animal regional anesthesia. Bovine blocks: continuousepidural anesthesia. Vet Med Small Anim Clin 75:1017-1029.
Grubb TL, Riebold TW, Crismann RO, Lamb LD (2002) Comparison of lidocaine, xylazine, and lidocaine-xylazine for caudal epidural analgesia in cattle. Vet Anaesth Analg 29:64-68.
Hall LW, Clarke KW, Trim CM (2000) Anesthesia of cattle. In: Veterinary Anesthesia. 10th ed. W.B. Saunders, New York: pp 315-341.
Ismail ZB (2016) Epidural analgesia in cattle, buffalo, and camels. Vet World 9:1450-1455.
Kasaba T, Onizuka S, Takasaki M (2003) Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics. Anesth Analg 97:85-90.
Luttinger D, Ferrari R, Perrone MH (1985) Pharmacological analgesis of alpha-2 adrenergic mechanisms in nociception and ataxia. J Pharmacol Exp Ther 232:883-889.
Mama K, Hendrickson DA, Baird AN (2013) Anesthesia and fluid therapy. Turner and McIlwraith’s techniques in large animal surgery. 4th ed, John Wiley & Sons, Inc., New York: pp 7-31.
McGrath C, Richey M (2003) Large animal anesthesia. In: Veterinary Anesthesia and Analgesia. Mosby, St. Louis: pp 387-412.
Natalini CC, Robinson EP (2000) Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am J Vet Res 61:1579-1586.
Newton DJ, McLeod GA, Khan F, Belch JJ (2007) Mechanisms influencing the vasoactive effects of lidocaine in human skin. Anaesthesia 62:146-150.
Saifzadeh S, Pourjafar M, Naghadeh BD, Jalali FS (2007) Caudal extradural analgesia with lidocaine, xylazine, and a combination of lidocaine and xylazine in the Iranian river buffalo (Bubalus bubalis). Bull Vet Inst Pulawy 51:285-288.
Shekidef MH, Saleh SY (2011) Effect of epidural administration of ketamine/xylazine and ketamine/medetomidine combination in dromedary camels. J Camel Pract Res 18:319-329.
Skarda RT (1996) Local and regional anesthesia in ruminants and swine. Anesthesiology update. Vet Clin North Am Food Anim Pract 12:579-662.
Skarda RT, Tranquilli WJ (2007) Local and regional anesthetic and analgesictechniques: ruminants and swine. In: Lumb & Jones’ Veterinary Anesthesia and Analgesia. 4th ed. Blackwell Publishing, Ames.: pp 643-680.
Trim CM (1981) Sedation and general anesthesia in ruminants. California Veterinarian 4:29-36.