@article{CHARALABIDIS (Σ. Θ. ΧΑΡΑΛΑΜΠΙΔΗΣ)_DIAKOU (Α. Ν. ΔΙΑΚΟΥ)_2017, title={Visceral Leishmaniosis and Canine Leishmaniosis in Greece and other mediterranean countries}, volume={55}, url={https://ejournals.epublishing.ekt.gr/index.php/jhvms/article/view/15100}, DOI={10.12681/jhvms.15100}, abstractNote={<p><span lang="EN-US">The prevalence of canine leishmaniosis in mediterranean countries varies from 0.2% to </span><em><span lang="EN-US">67% </span></em><span lang="EN-US">and annually, 1.4-300 cases of human infection are reported in each country. In Greece, 0.7-48.7% of dogs, 3.9% of cats, 1.2% of rodents </span><em><span lang="EN-US">(Citellus citellus) </span></em><span lang="EN-US">and 3.9-9.2% of inhabitants are seropositive, whereas 25 cases (mean annual rate) of visceral leishmaniosis are reported each year. As vector of the visceral leishmaniosis in Greece is considered the sand fly </span><em><span lang="EN-US">P. neglectus </span></em><span lang="EN-US">(0.12% infected by </span><em><span lang="EN-US">L. infantum) </span></em><span lang="EN-US">and additionally, as possible vectors the species </span><em><span lang="EN-US">P. sergenti, P.balcanicus </span></em><span lang="EN-US">and </span><em><span lang="EN-US">P.simici. </span></em><span lang="EN-US">No proven vector for the transmission of canine leishmaniosis has been found in Greece. As possible vectors are suspected </span><em><span lang="EN-US">P. </span></em><em><span lang="EN-US">perfìliewi </span></em><span lang="EN-US">and <em>P. tobbi. </em>No direct relation has been found between the incidence of canine leishmaniosis and the cases of the human infection in Greece. The sand flies and its preferable hosts in Greece are: <em>P. neglectus </em>(catde, horse, swine, rat, rarely human and never the dog), <em>P. perfìliewi </em>(dog, fox, catde, sheep, horse, swine, hare, rabbit, rodents), <em>P. tobbi </em>(sheep, dog, rabbit), <em>P. balcanicus </em>(bat, human), <em>P. simici </em>(rabbit, bat, human), <em>P. papatasi </em>(human), <em>P. sergenti </em>(human, rabbit, bat), <em>P. similis </em>(bat, rarely the human), <em>P. alexandri </em>(human, rodents), <em>P. mascittii </em>(dog, fox, human), <em>Sergentomyia minuta </em>(lizard, probably the fowls) and <em>S. dentata </em>(lizard, probably the fowls). The outcome of the disease is determined by a Th2 pattern (while Thl pattern results an effective cellular response and the self limitation of the disease) and the rupture of monocytes/ macrophages (multiplication of parasite), which is resulting in the lessions and the disfunction of spleen, bone marrow, liver, skin, lymphnodes, intestine, eye, membrane e.t.c, through the chronically high concentrations of immunocomplexes and the activation of complement (classic way) e.t.c. Mostly, </span><span lang="EN-US">diagnosis is established by the detection of the parasite and the detection of anti-leishmanial antibodies. The commonly used drugs to treat canine leishmaniosis are leishmanicids (meglumine antimoniate, aminosidine sulphate), leishmaniostatics (allopurinol, ketoconazole), immunostimmulants e.t.c. Repellents and insecticids (collars, shampoos, sprays) should be used to protect the dogs from May to November, while the infected dogs should be early diagnosed and treated.</span></p>}, number={3}, journal={Journal of the Hellenic Veterinary Medical Society}, author={CHARALABIDIS (Σ. Θ. ΧΑΡΑΛΑΜΠΙΔΗΣ) S. and DIAKOU (Α. Ν. ΔΙΑΚΟΥ) A.}, year={2017}, month={Dec.}, pages={247–261} }