The medical use of Málaka wine and cola nuts in late 19th/early 20th century Greece

Abstract

The lands of Malaka in Spain have been renowned for their wine since the 8th century BC. Malaka wine gained popularity among merchants and consumers since the 17th century, becoming one of Europe’s favourites. The seeds (nuts) of the African Cola acuminata trees had been used in daily life as an invigorating and stimulating chewing or eating delicacy. In the late 19th century, Stamatios Krinos, who had opened one of the first (or the first) pharmacies in Athens in 1836, and his son Athanasios, produced an Elixir named Krinos Cola Wine to treat neurasthenia, chlorosis, anaemia, indigestion, gastralgia, chronic diarrhoea, cardiopathies, weakness and infertility. The properties of both the wine and the nuts, along with the chemical compounds of cola, were already known by the mid-19th century and the Krinos family took advantage of this knowledge to introduce a novel herbal drug (cola seeds) to the Hellenic pharmacopeia. The properties attributed to the Krinos elixir are de novo and in depth validated today by a series of modern medical studies. The fact that cola was not included as a therapeutic agent in the Hellenic textbooks of pharmacology of that era suggests that Krinos made an innovative addition to the timelessly popular Hellenic herbal medicine and pharmacopeia.