GISSI, CARMELA, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy IBIOM, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), CNR, Via Amendola 165/A, 70126 Bari, Italy and CoNISMa, Piazzale Flaminio 9, 00197, Roma, Italy, Italy