Contemporary aspects on the immunopathogenesis of pemphigus group in the dog

Published: Dec 6, 2017
Epidermis pemphigus dog immunopathogenesis

Autoimmune diseases of the canine epidermis originate from the activation of the immune system against some adhesion molecules, which link the keratinocytes. Epidermal autoimmunity eventually induces acantholysis, which is thepathological hallmark of these skin diseases. In this review article, a thorough analysis of the immunopathogenesis for each of these skin diseases has been attempted along with the mechanisms that modulate the process of acantholysis. Epidermal autoimmune diseases in the dog include pemphigus foliaceus, vulgaris, panepidermal pustular, erythematosus, paraneoplastic and pharmaceutical. The recent advances in immunopathological and molecular techniques have markedly facilitated the understanding of their pathogenesis, thus giving the opportunity for the development of new therapeutic strategies that may lead to their successful treatment.

Article Details
  • Section
  • Review Articles
Download data is not yet available.
Affolter V.K (2000) The skin immune system, Proceedings of theWorkshop on skin immunology organized by ESVD, France, pp:65-93.
Amagai M., Klaus-Kontum V. and Stanley J.R. (1991) Autoantibodies against a novel epithelial in pemphigus vulgaris, a disease of cell adhesion. Cell, 67: 869-877.
Brenner S., Walt R. and Ruocco V. (1993) Drug-induced pemphigus LA survey, Clinics in Dermatology, 11: 501-505.
Carlotti D., Terrier S., Collinot C. and Dierrat C. (1999) Pemphigus vulgaris in the dog: a report of 8 cases, Proceedings of the AAVD/ACVD Annual Meeting, Maui, Hawaii, pp: 21-22.
Day M.J. (1999) Clinical Immunology of the Dog and Cat, Manson Publishing, UK.
de Bruin A, Muller E., Wyder M., Auhalt G.J, Lemmens P., Suter M.M (1999) Periplakin and envoplakin are target antigens in canine and human paraneoplastic pemphigus, Journal of the American Academy of the Dermatology, 40:682-685.
Fukuda E et al. (1998) Pemphigus erythematosus in a Shetland sheepdog, J Vet Med (Tokyo) 51:24
Garrod D., Chidgey M. and North A. (1996) Desmosomes: Differentiation, development, dynamics and disease. Curr Opin Cell Biol, 8:670-678.
Ihrke P.J., Stannard AA, Ardans AA and Griffin CE. (1985) Pemphigus foliaceus in dogs: a review of 37 cases, Journal of the American Veterinary Association, 186: 59-66.
Iwasaki T. and Maeda Y. (1997) The effect of ultraviolet (UV) on the severity of canine pemphigus erythematosus, Proceedings of the AAVD/ACVD Annual Meeting, Nashville, TN, p: 86.
Iwasaki T., Shimizu M., Obata H. et al. (1997) Detection of canine pemphigus faliaceus autoantigen by immunoblotting, Veterinary Immunology and Immunopathology, 59: 1-10.
Janeway CA and Travers P. (1997) Immunobiology, The immune system in health and disease, 3rd edition, Current Biology and Garland Pubi., London, UK.
Kwochka K.W (1993) Keratinization Abnormalities: Understanding the mechanisms of scale formation, Advances in Veterinary Dermatology, volume 2, Pergamon Press, pp:91-lll.
Lemmens P., de Bruin A , Demenlemeester J., Wyder M., Suter M.M. (1998) Paraneoplastic pemphigus in a dog. Veterinary Dermatology, 9: 127-134.
Lin M.S and Mascar J.M.J. (1997) The desmosomes and hemidesmosome in cutaneous autoimmunity, Clin Exp Immunol 107 (suppl): 9-15.
Lombardi M.L., de Angelis E., Rossano F. and Ruocco V. (1993) Imbalance between plasminogen activator and its inhibitors in thiol-induced acantholysis, Dermatology, 186: 118-122.
Olivry T. (2000) Mechanisms of Autoimmunity- Current concepts and Pemphigus in Domestic animals: comparative aspects, Proceedings of the workshop on Skin Immunology organized by the ESVD, Saint-Paul de Vence, France pp: 109-130.
Olivry T. and Chan L.S (2001) Autoimmune blistering dermatoses in domestic animals, Clinics in Dermatology, 19: 750-760.
Olivry T., Ihrke P.J. and Atlee BA. (1992) Pemphigus vulgaris lacking mucosal involvement in a German shepherd dog: possible response to heparin therapy, Veterinary Dermatology, 3: 79-84.
Rosenkrantz W.S (1993) Pemphigus foliaceus. In: Griffin et al. (eds): Current Veterinary Dermatology, Mosby-Year Book, St. Louis, USA, pp: 141
Scott D.W, Miller W.H., Lewis R.M., Manning T.O and Smith C.A (1980) Pemphigus erythematosus in the dog and the cat, JAAHA, 16: 815-823.
Scott D.W., Walton D.K., Slater M.R., Smith C A and Lewis R.M. (1987) Immune-mediated dermatoses in domestic animals: Ten years after-part I, Compendium on Continuing Education for Practicing Veterinarian, 9: 424-434.
Scott D.W., Miller W.H. and Griffin C E (2001) Immune mediated disorders In: Small Animal Dermatology, 6th edition, W.B.Saunders Co, Philadelphia, pp:667-779.
Steinman L. (1995) Escape from "Horror Autotoxicus": pathogenesis and treatment of autoimmune diseases, Cell, 80: 7-10.
Suter M.M, de Bruin Α., Wyder M., Wurm S., Credule Κ., Crameri F.Μ and Muller E. (1998) Autoimmune diseases of Domestic animals: an update. In: KW.Kwochka, T.Willemse and C.V Tscharner (eds): Advances in Veterinary Dermatology, vol.3, Butterworth Heinemann, Oxford pp: 321-334.
Udey M.C and Stanley J.R. (1999) Pemphigus -Diseases of antidesmosomal autoimmunity, JAMA 282: 572-576.
Werner L.L., Brown KA and Halliwell R.E.W. (1983) Diagnosis of autoimmune skin diseases in the dog: correlation between histopathologic, direct immunofluorescence and clinical findings, Veterinary Immunology and Immunopathology, 5: 47-64.
White S.D., Carlotti D.N., Pin D., Bonenberger T., Ihrke P.J Monet E., Nishifuji K., Iwasaki T. and Papich M.G (2002) Putative drug-related pemphigus faliaceus in four dogs, Veterinary Dermatology, 13: 195-202.
Wolf R. and Ruocco V. (1997) Gaining more insight into the pathomechanisms of thiol-induced acantholysis, Medical Hypotheses, 48: 107-110.
Wurms S., Mattise AW. and Dustan R.W. (1994) Comparative pathology of pemphigus in dogs and humans. Clinics in Dermatology, 12: 515-524.