Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials
Published:
Jan 29, 2018
Keywords:
multi-drug resistant Staphylococcus pseudintermedius dog Public Health significance
Abstract
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as an important pathogen in the dog over the past 10 years with an ever increasing incidence worldwide. This review focuses mainly on the epidemiology and detection of MRSP, emphasizing on the interpretation and pitfalls of screening laboratory tests and antimicrobial susceptibility tests. Risk factors for colonization and infection with MRSP and molecular analysis of the dominant clonal lineages are also described. The zoonotic potential and worldwide epidemiology of multidrug resistant Staphylococcus pseudintermedius (MDRSP) are presented. Finally, control options for the colonization of healthy dogs as well as infection by MRSP and MDRSP are described emphasizing on the indications for bacterial culture and susceptibility testing and the principles of topical therapy which may prove to be the sole effective treatment in several canine pyoderma cases.
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PAPADOGIANNAKIS (Ε. ΠΑΠΑΔΟΓΙΑΝΝΑΚΗΣ) E., VELONAKIS (E. ΒΕΛΟΝΑΚΗΣ) E., & VATOPOULOS (Α. ΒΑΤΟΠΟΥΛΟΣ) A. (2018). Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials. Journal of the Hellenic Veterinary Medical Society, 67(2), 109–116. https://doi.org/10.12681/jhvms.15629
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- Vol. 67 No. 2 (2016)
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- Review Articles
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References
Bannerman TL (2003) Staphylococcus, Micrococcus and other Gram-positive cocci that grow aerobically. Manual of Clinical Microbiology. Washington, DC: American Society for Microbiology, pp:384-404.
Bannoehr J, Guardabassi L (2012) Staphylococcus pseudintermedius in the dog: taxonomy, diagnostics, ecology, epidemiology and pathogenicity. Veterinary Dermatology 23:253–266.
Bardiau M, Yamazaki K, Ote I, Misawa N, Mainil JG (2013) Characterization of methicillin-resistant Staphylococcus pseudintermedius isolated from dogs and cats. Microbiology Immunology 57: 496–501.
Bemis DA, Jones RD, Frank LA, et al (2009) Evaluation of susceptibility test breakpoints used to predict mecA-mediated resistance in Staphylococcus pseudintermedius isolated from dogs. Journal of Veterinary Diagnostic Investigation 21: 53-58.
Bond R, Loeffler A (2012) What’s happened to Staphylococcus intermedius? Taxonomic revision and emergence of multidrug resistance. Journal of Small Animal Practice 53:147-154.
Campanile F, Bongiorno D, Borbone S, Venditti M, Giannella M, Franchi C, Stefani S (2007) Characterization of a variant of the SCCmec element in a bloodstream isolate of Staphylococcus intermedius. Microbial Drug Resistance 13: 7-10.
Chanchaithong P, Prapasarakul N (2011) Biochemical markers and protein pattern analysis for canine coagulase-positive staphylococci and their distribution on dog skin. Journal of Microbiological Methods 86: 175-181.
Coombs GW, Nimmo GR, Bell JM, Huygens F, O’Brien FG, Malkowski MJ, Pearson JC, Stephens AJ, Giffard PM (2004) Genetic diversity among community methicillin-resistant Staphylococcus aureus strains causing outpatient infections in Australia. Journal of Clinical Microbiology 42: 4735-4743.
Davis JA, Jackson CR, Fedorka-Cray PJ, Barrett JB, Brousse JH, Gustafson J, Kucher M (2014) Carriage of methicillin-resistant staphylococci by healthy companion animals in the US. Letters in Applied Microbiology 59: 1-8.
De Lucia M, Moodley A, Latronico F et al (2011) Prevalence of canine methicillin resistant Staphylococcus pseudintermedius in a veterinary diagnostic laboratory in Italy. Research in Veterinary Science 91: 346–348.
Detwiler A, Bloom P, Petersen A, Rosser EJ Jr (2013) Multidrug and methicillin resistance of staphylococci from canine patients at a veterinary teaching hospital (2006-2011). Veterinary Quarterly 33: 60-67.
Devriese LA, De Pelsmaecker K. (1987) The anal region as a main carrier site of Staphylococcus intermedius and Streptococcus canis in dogs. Veterinary Record 121: 302–303.
Devriese LA, Hermans K, Baele M et al. (2009) Staphylococcus pseudintermedius versus Staphylococcus intermedius. Veterinary Microbiology 133: 206–207.
Feng Y, Tian W, Lin D, Luo Q, Zhou Y, Yang T, Deng Y, Liu YH, Liu JH (2012) Prevalence and characterization of methicillin-resistant Staphylococcus pseudintermedius in pets from South China. Veterinary Microbiology 160:517–524.
Frank LA, Kania SA, Kirzeder EM et al. (2009) Risk of colonization or gene transfer to owners of dogs with meticillin-resistant Staphylococcus pseudintermedius. Veterinary Dermatology 20: 496–501.
Frank LA, Loeffler A (2012) Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options. Veterinary Dermatology 23:283-291.
Ganiere JP, Medaille C, Mangion C (2005) Antimicrobial drug susceptibility of Staphylococcus intermedius clinical isolates from canine pyoderma. J Vet Med 52: 25–31.
Gerstadt K, Daly JS, Mitchell M, Wessolossky M, Cheeseman SH (1999) Methicillin-resistant Staphylococcus intermedius pneumonia following coronary artery bypass grafting. Clinical Infectious Diseases 29: 218-219.
Gold RM and Lawhom SD (2013) Incidence of inducible clindamycin resistance in Staphylococcus pseudintermedius from dogs. Journal of Clinical Microbiology 51: 4196-4199.
Goodacre R, Harvey R, Howell SA, Leighton W. Greenham LW, Noble WC (1997) An epidemiological study of Staphylococcus intermedius strains isolated from dogs, their owners and veterinary surgeons. Journal of Analytical and Applied Pyrolysis 44: 49–64.
Gortel K, Campbell KL, Kakoma I, Whittem T, Schaeffer DJ, Weisiger RM (1999) Methicillin resistance among staphylococci isolated from dogs. American Journal of Veterinary Research 60:1526–1530.
Griffeth GC, Morris DO, Abraham JL, Shofer FS, Rankin SC (2008) Screening for skin carriage of methicillin-resistant coagulase-positive staphylococci and Staphylococcus
schleiferi in dogs with healthy and inflamed skin. Veterinary Dermatology 19:142-149.
Guardabassi L, Loeber ME, Jacobson A (2004) Transmission of multiple antimicrobial-resistant Staphylococcus intermedius between dogs affected by deep pyoderma and their owners. Veterinary Microbiology 98: 23–27.
Hanselman BA, Kruth SA, Rousseau J et al. (2009) Coagulase positive staphylococcal colonization of humans and their household pets. Canadian Veterinary Journal 50: 954–958.
Harvey RG, Marpless RR, and Noble WC (1994) Nasal Carriage of Staphylococcus interrnedius in Humans in Contact with Dogs. Microbial Ecology in Health and Disease 7: 225-227.
Jones RD, Kania SA, Rohrbach BW et al. (2007) Prevalence of oxacillin and multidrug-resistant staphylococci in clinical samples from dogs: 1,772 samples (2001–2005). J Am Vet Med Assoc 230: 221–227.
Kempker R, Mangalat D, Kongphet-Tran T et al (2009) Beware of the pet dog: a case of Staphylococcus intermedius infection. The American Journal of Medical Sciences 338: 425-427.
Laarhoven LM, de Heus P, van Luijn J, Duim B, Wagenaar JA, van Duijkeren E (2011) Longitudinal study on methicillin-resistant Staphylococcus pseudintermedius in households. PLoS One 6: e27788.
Latronico F, Moodley A, Nielsen SS, Guardabassi L (2014). Enhanced adherence of methicillin-resistant Staphylococcus pseudintermedius sequence type 71 to canine and human corneocytes. Veterinary Research 45:70.
Lehner G, Linek M, Bond R, Lloyd DH, Prenger-Berninghoff E, Thom N, Straube I, Verheyen K, Loeff ler A (2014) Case-control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany. Veterinary Microbiology 168: 154-60.
Loeff ler A, Boag AK, Sung J, Lindsay JA, Guardabassi L, Dalsgaard A, Smith H, Stevens KB, Lloyd DH (2005) Prevalence of methicillin-resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK. Journal of Antimicrobial Chemotherapy 56: 692-697.
Loeff ler A, Linek M, Moodley A, Guardabassi L, Sung JM, Winkler M, Weiss R, Lloyd DH (2007) First report of multiresistant, mecA-positive Staphylococcus intermedius in Europe: 12 cases from a veterinary dermatology referral clinic in Germany. Veterinary Dermatology 18:412-421.
Loeffler A, Pfeiffer DU, Lindsay JA, Soares-Magalhaes R, Lloyd DH (2010) Lack of transmission of methicillin-resistant Staphylococcus aureus (MRSA) between apparently healthy dogs in a rescue kennel. Veterinary Microbiology 141:178-181.
Loeff ler A, Pfeiffer DU, Lloyd DH et al. (2010a) Meticillinresistant Staphylococcus aureus carriage in UK veterinary staff and owners of infected pets: newrisk groups. J Hosp Infect 2010; 74: 282–288.
Mahoudeau I, Delabranche X, Prevost G et al (1997) Frequency of isolation of Staphylococcus intermedius from humans. Journal of Clinical Microbiology 35: 2153-2154.
Morris DO, Rook KA, Shofer FS et al (2006) Screening of Staphylococcus aureus, Staphylococcus intermedius, and Staphylococcus schleiferi isolates obtained from small companion animals for antimicrobial resistance: a retrospective review of 749 isolates (2003–04). Veterinary Dermatology 17: 332-337.
Murayama N, Terada Y, Okuaki M et al. (2011) Contact time of 2% chlorhexidine acetate for canine superficial pyoderma. Vet Dermatol 22: 449–453.
Nienhoff U, Kadlec K, Chaberny IF et al. (2011). Methicillinresistant Staphylococcus pseudintermedius among dogs admitted to a small animal hospital. Vet Microbiol 150: 191–7.
Nuttall T, Williams N, Saunders R, Dawson S (2008) Meticillinresistant staphylococci in companion animals. European Journal of Companion Animal Practice 18: 280-287.
Ohara-Nemoto Y, Haraga H, Kimura S, Nemoto TK (2008) Occurrence of staphylococci in the oral cavities of healthy adults and nasal oral trafficking of the bacteria. Journal of Medical Microbiology 57: 95-99.
Osland AM, Vestby LK, Fanuelsen H, Slettemeås JS, Sunde M (2012) Clonal diversity and biofilm-forming ability of methicillin-resistant Staphylococcus pseudintermedius. Journal of Antimicrobial Chemotherapy 67: 841-848.
Papich MG (2010) Proposed changes to Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs. Journal of Veterinary Diagnostic Investigation 22: 160.
Paul NC, Moodley A, Ghibaudo G, Guardabassi L (2011) Carriage of methicillin resistant Staphylococcus pseudintermedius in small animal veterinarians: indirect evidence of zoonotic transmission. Zoonoses and Public Health 58: 533-539.
Perreten V, Kadlec K, Schwarz S, Grönlund Andersson U, Finn M, Greko C, Moodley A, Kania SA, Frank LA, Bemis DA, Franco A, Iurescia M, Battisti A, Duim B, Wagenaar JA, van Duijkeren E, Weese JS, Fitzgerald JR, Rossano A, Guardabassi L (2010) Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North
America: an international multicentre study. Journal of Antimicrobial Chemotherapy 65: 1145-1154.
Pottumarthy S, Schapiro JM, Prentice JL et al (2004) Clinical isolates of Staphylococcus intermedius masquerading as methicillin resistant Staphylococcus aureus. Journal of Clinical Microbiology 42: 5881-5884.
Rubin JE, Ball KR, Chirino-Trejo M (2011) Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus pseudintermedius isolated from various animals. Can Vet J 52: 153–157.
Ruscher C, Lübke-Becker A, Wleklinski CG et al. (2009) Prevalence of methicillin-resistant Staphylococcus pseudintermedius isolated from clinical samples of companion animals and equidaes. Veterinary Microbiology 136: 197-201.
Ruscher C, Lübke-Becker A, Semmler T, Wleklinski CG, Paasch A, Soba A, Stamm I, Kopp P, Wieler LH, Walther B (2010) Widespread rapid emergence of a distinct methicillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) genetic lineage in Europe. Veterinary Microbiology 144: 340-346.
Saridomichelakis M.N., Koutinas A.F., Heliadis Ν., Georgopoulou I., Leontides L (2002) Antibiotic resistance of Staphylococcus intermedius strains isolated from 53 natural cases of canine pyoderma. Journal of Hellenic Veterinary Medical Society 53: 325-334.
Sasaki T, Kikuchi K, Tanaka Y et al. (2007) Methicillin-resistant Staphylococcus pseudintermedius in a veterinary teaching hospital. Journal of Clinical Microbiology 45: 1118-1125.
Siak M, Burrows AK, Coombs GW, Khazandi M, Abraham S, Norris JM, Weese JS, Trott DJ (2014) Characterization of meticillin-resistant and meticillin-susceptible isolates of Staphylococcus pseudintermedius from cases of canine pyoderma in Australia. Journal of Medical Microbiology 63:1228-1233.
