The mouse and the rat in surgical research. The anesthetic approach

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Published: Jan 29, 2018
DOI: https://doi.org/10.12681/jhvms.15633
Keywords:
analgesia anesthesia mouse rat surgery research welfare
I. CHANIOTAKIS
Veterinary Department, Medical Directorate of Hellenic Airforce; Centre of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens
A. SPYRLIADIS
Centre of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens
M. KATSIMPOULAS
Centre of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens
N. KOSTOMITSOPOULOS
Centre of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens
Abstract

The mouse and the rat are currently overwhelmingly preferred as laboratory animals. Surgical research on animals requires anesthesia and analgesia to obtain adequate immobility and to reduce stress and pain. Small rodent anesthesia is challenging for several reasons including the animals’ size, metabolic rate, high risk of hypothermia and difficulty in monitoring. The purpose of this study is to create an overview of the information in the anesthetic practices for small rodents, in particular mice and rats.

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