First report of granulosa cell tumour associated with an endometrial adenoma in a crossbreed cow in Portugal


Keywords:
granulosa cell tumour ovary endometrial adenoma cattle
D. MOURA
J. GARCÍA-DÍEZ
C. SARAIVA
M. A. PIRES
Abstract

A 12.5 year-old female crossbred cow without clinical signs at ante mortem inspection was slaughtered. The post-mortem inspection revealed poor carcass condition, interstitial nephritis and generalized lymphadenitis. The reproductive tract presented an unilateral and highly vascularized yellowish-white mass, with huge dimensions (60 x 40 cm and 20 Kg, approximately) described as granulosa cell tumour (GCT) and a endometrial adenoma, after histopathological analysis. GCT has been described as the most frequent ovarian tumour in cattle. Since clinical signs are usually unspecific, the post mortem diagnosis by histopathology examination is always necessary. The endometrial adenoma could be asymptomatic, with only absence of calving, or associated with GCT. This is, of our knowledge, the first report of a GCT associated with endometrial adenoma in a cow in Portugal.

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References
Agnew DW, MacLachlan NJ (2017) Tumors of the genital systems. In Meuten DJ (Ed.) Tumors in Domestic Animals, 5th Ed. Wiley. Pp 689-722.
Anderson LJ, Sandison AT (1969) Tumours of the female genitalia in cattle, sheep and pigs found in a British abattoir survey. J Comp Pathol 79:53-63.
Bosu WTK (1977) Granulosa cell tumor in a cow: clinical, hormonal, and histopathological observations. Theriogenology 8:119-128.
Hosteller DE, Sprecher DJ, Yamini B, Ames NK (1997) Diagnosis and management of a malignant granulosa cell tumor in a Holstein nulligravida: A case study. Theriogenology48:11-17.
Leder RR, Lane VM, Barrett DP (1988) Ovariectomy as treatment for granulosa cell tumor in a heifer. J Am Vet Med Assoc 192:1299-1300.
Kennedy PC, Cullen JM, Edwards JM, Goldshmidt MH, Larsen S, Munson L, Nielsen S (1998) Histological Classification of Tumors of the Genital System of Domestic Animals. 1st ed. Washington, DC, USA: Armed Forces Institute of Pathology in Cooperation with the American Registry of Pathology and The World Health Organization Collaborating Center for Worldwide Reference on Comparative Oncology.
Patnaik AK, Greenlee PG (1987) Canine ovarian neoplasms: a clinicopathologic study of 71 cases, including histology of 12 granulosa cell tumors. Vet Pathol 24:509-514.
Garcia-Iglesias MJ, Bravo-Moral AM, Perez-Martinez C, Ferreras-Estrada MC, Martinez-Rodriguez JM, Escudero-Diez (1995) Incidence and pathomorphology of uterine tumours in the cow. J Vet Med Series A 42:421-429.
Farin PW, Estill CT (1993) Infertility due to abnormalities of the ovaries in cattle. Vet Clin North Am Food AnimPract9:291-308.
Short RV, Shorter DR, Linzel JL (1963) Granulosa cell tumour of the ovary in a virgin heifer. J Endocrin 27:327-NP.
Masseau I, Fecteau G, Desrochers A, Francoz D, Lanthier I, Vaillancourt D (2004) Hemoperitoneum caused by the rupture of a granulosa cell tumor in a Holstein heifer. Can Vet J 45:504.
Payan-Carreira R, Saraiva AL, Santos T, Vilhena H, Sousa A, Santos C, Pires MA (2013). Feline endometrial adenocarcinoma in females < 1 year old: a description of four cases. RepDom An 48:e70-e77.
Pires MA, Vilhena H, Miranda S, Tavares Pereira M, Seixas F, Saraiva AL (2016) Proliferative endometrial lesions hidden behind the feline pyometra. (2016) In Insights from Animal Reproduction. Chapter 10. Ed. Rita Payan-Carreira. In Tech. Pp
-242. http://dx.doi.org/10.5772/62788. ISBN 978-953-51-2268-5.
Saraiva AL, Payan-Carreira R, Gärtner F, da Cunha MRF, Rêma A, Faria F, Lourenço LM, dos Anjos Pires M (2015) An immunohistochemical study on the expression of sex steroid receptors, Ki-67 and cytokeratins 7 and 20 in feline endometrial adenocarcinomas. BMC Vet Res 11:204.
Lucena RB, Rissi, DR, Kommers GD, Pierezan F, Oliveira-Filho JC, Macedo JTSA, Flores MM, Barros CSL (2011) A retrospective study of 586 tumours in Brazilian cattle. J Comp Pathol 145:20-24.
Kitahara G, Nambo Y, Hossam EL, Kajisa M, Mineto TANI, Kazumi NIBE, Kamimura S (2012) Anti-Müllerian hormone profiles as a novel biomarker to diagnose granulosa-theca cell tumors in cattle. J Rep Dev 58:98-104.
Kanagawa H, Kawata K, Nakao N, Sung WK (1964) A case of granulosa cell tumor of the ovary in a newborn calf. Japan J Vet Res 12:7-11.
Zachary JF, Haliburton JC (1983) Malignant granulosa cell tumor in an Angus cow. Vet Pathol20:506-509.
Dobson H, Kerby MJ, Chantrey J, Smith RF (2013) Long-term outcome for two heifers with a granulosa-theca cell tumour. An Rep Sci 37:121-131.
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