Effect of estrogens on the binding capacity of specific proteins of animal sera


Α. ΠΑΠΑΝΑΣΤΑΣΙΟΥ
Ι. ΜΑΝΤΖΟΣ
Γ. ΠΙΤΣΙΝΙΔΗΣ
Ε. ΠΑΠΑΔΟΠΟΥΛΟΣ
Λ. ΕΥΣΤΑΘΙΟΥ
Abstract

The effect of estrogens (diethylstibestrol and estradiol benzoate) on the binding capacity of specific proteins of animal sera which bind the thyroid hormones and the folic acid was studied, lor this study two sheepi two goats and two pigs used. It was found that diethlstilbestrol reduces the binding capacity of the specific proteins which bind thyroid hormones, of the sheep and goat serum and estradiol benzoate increases it. Increase was also found after the administration of both hormones to the pigs. Reduction of the binding capacity of serum specific proteins of the folic acid, was found after estrogen administration to the two pigs and the one goat. In the case of the other animals the changes in the binding capacity of folic acid were too small to be evaluated.

Article Details
  • Section
  • Articles
Downloads
Download data is not yet available.
References
Dowling, J. T., Freinkel, Ν., Ingbar, S.H. (1960): The effect of estrogens upon the peripheral metabolism of Thyroxine. J. Clin. Invest. Vol. 3, 119.
Mantzos, J. D., Alevizou-Terzaki, V. Gyftaki, E. (1974): Folate binding in Animal plasma. Acta Hematologica. Vol. 51, 204-210.
Mantzos, J.D. (1975): Radioassay of serum folate with use of pig plasma folate binders. Acta Hematologica, Vol 54,289-296.
Markkanen, T., Himanen, P. Pajuba, R.L., Ruponens., Castren, 0. (1973). Binding of folic acid to serum proteins, folic acid to serum proteins. 1. The effect of pregnancy. Acta Hematologica, vol. 50,85.
Most read articles by the same author(s)