The effect of progesterone on the anesthetic and analgesic requirements for ovariohysterectomy in the dog
Keywords:
Progesterone allopregnanolone dog anesthesia ovariohysterectomy
Abstract
The objective of the current study was to investigate the effect of serum progesterone concentration, either endogenous, during the ovarian cycle and pregnancy, or exogenous, when administered during anestrus, and of its active metabolite allopregnanolone, on anesthetic and analgesic requirements, as well as post-operative pain intensity, for the performance of ovariohysterectomy in dogs. One hundred and fifty healthy female dogs, which were admitted to our clinic for elective ovariohysterectomy, were included in the present study. They were allocated to 6 groups according to the stage of the ovarian cycle and the corresponding serum progesterone co ncentration. The six groups consisted of dogs in anestrus (group A), in anestrus which received intramuscular progesterone injections prior to surgery (group Ap), dogs in diestrus (group D), in diestrus which received subcutaneous aglepristone injections prior to surgery (group Da), in diestrus which received oral trilostane prior to surgery (group Dt) and dogs in pregnancy of duration of 28-42 days (group P). Serum progesterone concentrations were measured in all dogs before and after any hormonal treatment and serum allopregnanolone concentrations were measured in selected dogs from all groups. The required dose of propofol for induction of anesthesia and the required isoflurane concentration for maintenance of anesthesia and the need for intraoperative fentanyl administration and extra postoperative pethidine analgesia were recorded. After statistical analysis, there were no significant differences between groups, regarding their anesthetic or analgesic requirements, that could be attributed to serum progesterone and/or allopregnanolone concentration. However, moderate correlations within certain groups were noted. Serum progesterone or allopregnanolone concentrations do not seem to have an effect on anesthetic and analgesic requirements for ovariohysterectomy in the dog or any potential effect is weak enough to be masked by the action of anesthetic premedication and/or analgesic and/or anaesthetic drugs used.
Article Details
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KOSTAKIS, C., ANAGNOSTOU, T., SAVVAS, I., VERVERIDIS, C., & KOURELIS, A. (2019). The effect of progesterone on the anesthetic and analgesic requirements for ovariohysterectomy in the dog. Journal of the Hellenic Veterinary Medical Society, 70(3), 1717–1726. https://doi.org/10.12681/jhvms.21798
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- Vol. 70 No. 3 (2019)
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- Research Articles
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References
Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC, Andersen RN (1988) Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites American journal of obstetrics and gynecology 159:1203-1209.
Atkinson RM, Davis B, Pratt MA, Sharpe HM, Tomich EG (1965) Action of some steroids on the central nervous system of the mouse. II. Pharmacology J Med Chem 8:426-432 doi:10.1021/jm00328a004.
Chan MT, Mainland P, Gin T (1996) Minimum alveolar concentration of halothane and enflurane are decreased in early pregnancy ANESTHESIOLOGY 85:782-786.
Columbano N, Secci F, Careddu GM, Sotgiu G, Rossi G, Driessen B (2012) Effects of lidocaine constant rate infusion on sevoflurane requirement, autonomic responses, and postoperative analgesia in dogs undergoing ovariectomy under opioid-based balanced anesthesia The Veterinary Journal 193:448-455 doi:https://doi.org/10.1016/j.tvjl.2011.12.005.
Concannon PW, Hansel W, Visek WJ (1975) The ovarian cycle of the bitch: plasma estrogen, LH and progesterone Biology of reproduction 13:112-121.
Cugell DW, Frank NR, Gaensler EA, Badger TL (1953) Pulmonary function in pregnancy. I. Serial observations in normal women American review of tuberculosis 67:568-597.
Datta S, Migliozzi RP, Flanagan HL, Krieger NR (1989) Chronically administered progesterone decreases halothane requirements in rabbits Anesth Analg 68:46-50.
de Gier J, Wolthers CHJ, Galac S, Okkens AC, Kooistra HS (2011) Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog Theriogenology 75:1271-1279. doi:https://doi.org/10.1016/j.theriogenology.2010.11.041.
Eger EI, 2nd, Saidman LJ, Brandstater B (1965) Minimum alveolar anesthetic concentration: a standard of anesthetic potency Anesthesiology 26:756-763.
Erden V, Yangin Z, Erkalp K, Delatioglu H, Bahceci F, Seyhan A (2005) Increased progesterone production during the luteal phase of menstruation may decrease anesthetic requirement Anesth Analg 101:1007-1011, table of contents doi:10.1213/01.ane.0000168271.76090.63.
Fu F, Chen X, Feng Y, Shen Y, Feng Z, Bein B (2014) Propofol EC50 for inducing loss of consciousness is lower in the luteal phase of the menstrual cycle BJA: British Journal of Anaesthesia 112:506-513. doi:10.1093/bja/aet383
Gin T, Chan MT (1994) Decreased minimum alveolar concentration of isoflurane in pregnant humans ANESTHESIOLOGY 81:829-832.
Gin T, Mainland P, Chan MT, Short TG (1997) Decreased thiopental requirements in early pregnancy ANESTHESIOLOGY 86:73-78.
Korneyev A, Costa E (1996) Allopregnanolone (THP) mediates anesthetic effects of progesterone in rat brain Horm Behav 30:37-43. doi:10.1006/hbeh.1996.0006.
Lawrence CJ, Lange SD (1997) Effects of a single pre‐operative dexmedetomidine dose on isoflurane requirements and peri‐operative haemodynamic stability Anaesthesia 52:736-745 doi:10.1111/j.1365-2044.1997.169-az0303.x.
Lee J, Lee J, Ko S (2014) The relationship between serum progesterone concentration and anesthetic and analgesic requirements: a prospective observational study of parturients undergoing cesarean delivery Anesth Analg 119:901-905 doi:10.1213/ane.0000000000000366.
Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor Science (New York, NY) 232:1004-1007.
Matthews JN, Altman DG, Campbell MJ, Royston P (1990) Analysis of serial measurements in medical research British Medical Journal 300:230-235 doi:10.1136/bmj.300.6719.230.
Merryman W, Boiman R, Barnes L, Rothchild I (1954) Progesterone anesthesia in human subjects J Clin Endocrinol Metab 14:1567-1569.
Mongardon N et al. (2009) Predicted propofol effect-site concentration for induction and emergence of anesthesia during early pregnancy Anesth Analg 109:90-95 doi:10.1213/ane.0b013e3181a1a700.
Palahniuk RJ, Shnider SM, Eger EI, 2nd (1974) Pregnancy decreases the requirement for inhaled anesthetic agents ANESTHESIOLOGY 41:82-83.
Savvas I, Papazoglou LG, Kazakos G, Anagnostou T, Tsioli V, Raptopoulos D (2008) Incisional Block With Bupivacaine for Analgesia After Celiotomy in Dogs Journal of the American Animal Hospital Association 44:60-66 doi:10.5326/0440060.
Selye H (1941a) Anesthetic Effect of Steroid Hormones Proceedings of the Society for Experimental Biology and Medicine 46:116-121. doi:10.3181/00379727-46-11907.
Selye H (1941b) STUDIES CONCERNING THE ANESTHETIC ACTION OF STEROID HORMONES Journal of Pharmacology and Experimental Therapeutics 73:127-141.
Shimizu T, Inomata S, Tanaka M (2010) Progesterone decreases sevoflurane requirement in male mice: a dose-response study Br J Anaesth 104:603-605 doi:10.1093/bja/aeq068.
Strout CD, Nahrwold ML (1981) Halothane requirement during pregnancy and lactation in rats ANESTHESIOLOGY 55:322-323.
Tanifuji Y, Yasuda N, Kobayashi K, Eger EII (1986) Effect of Progesterone and Estrogen on Halothane Mac in Dogs ANESTHESIOLOGY 65:A351.
