Vitamin E and its impact on poultry production: An Update
Abstract
The main goals of recent poultry production sectors are to enhance the immune response of the birds, improve the performance, reduce mortalities and reduce stressors. These goals can be easily achieved through dietary supplementation with vitamins. Vitamin E is one of the fat-soluble vitamin that has been used from last decades for different poultry production types. The inoculation level of vitamin E in the diet of poultry depends on several factors. Low or high level of vitamin E can induce severe adverse economic losses in poultry industry. Vitamin E has been regarded as a potent chain-breaking antioxidant as well as immuno-stimulator for both cell-mediated and humoral immunity. Vitamin E is added to the diet of broilers, layers and breeders especially those under heat stress conditions. In broilers, vitamin E can improve the health conditions, feed efficiency and immunity. However, in layers and breeders, it enhances the egg’s quantity and quality as well as the fertility; respectively. Moreover, vitamin E proves its efficacy in modifying the carcass trait or meat quality of broilers. Therefore, this review article aimed to investigate the forms and inoculation levels vitamin E, the role of this vitamin in the biological process as well as its effect on different poultry production types and carcass quality.
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Abd El-Ghany, W. (2022). Vitamin E and its impact on poultry production: An Update. Journal of the Hellenic Veterinary Medical Society, 73(1), 3571–3582. https://doi.org/10.12681/jhvms.25836
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- Vol. 73 No. 1 (2022)
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- Review Articles
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References
Aamir N, Shuyan T, Wenchao L, Jiang W, Fahar I, Kai K, Muhammad WG, Muhammad WB,
Guanghui L, Chenyu S, Yi Z, Mei X,Lilong A (2019) Vitamin E and fertility in the poultry
birds; deficiency of vitamin E and its hazardous effects. Approaches Poult Dairy VetSci
: 501-506.
Abdel Maksoud AM (1999) Influence of ascorbic acid supplementation on some hormonal and
hematological responses in Japanese quail exposed to acute heat stress. Egypt J Nutr
Feeds 2: 729-742.
Abdukalykova ST, Ruiz-Feria CA (2006). Arginine and vitamin E improve the cellular and
humoral immune response of broiler chickens. Int J PoultSci 5: 121-127.
Abdukalykova ST, Zhao X, Ruiz-Feria CA (2008) Arginine and vitamin E modulate the
subpopulations of T lymphocytes in broiler chickens. PoultSci 87: 50-55.
Aburto A, Britton WM (1998) Effects and interactions of dietary levels of vitamins A and E and
cholecalciferol in broiler chickens. PoultSci 77: 666-673.
Anwar H, Iftikhar A, Sohail MU, Hussain G, Faisal MN, Khan J, Bukhari SA, Iqbal Z (2016)
Efficacy of various post-moult feed supplementations in poultry: an empirical review.
World’s PoultSci J 72: 619-627.
Aravind KL, Gowda CV, ManjunathBP, RajendraAY, GanpuleSP (2001) Influence of dietary
level of selenium and vitamin E on growth, immunity and carcass traits in broiler chickens.
Ind J PoultSci 36: 58-62.
Arslan M, Özcan M, Matur E, Çöteloglu, Ergül E (2001) The effects of vitamin E on some blood
parameters in broilers. Turk J Vet AnimSci 25: 711-716.
Asl SR, Shariatmadari F, Sharafi M, Torshizi KMA, Shahverdi A (2018) Dietary fish oil
supplemented with vitamin E improves quality indicators of rooster cold-stored semen
through reducing lipid peroxidation. Cryobiology 84: 15-19.
Attia YA, Al-HarthiMA, ElShafeyAS, Rehab YA, Kyun Kim W (2017) Enhancing tolerance of
broiler chickens to heat stress by supplementation with vitamin E, vitamin C and/ or
probiotics. Ann AnimSci 17: 1155-1169.
Attia YA,Abd El-Hamid AE, Abedalla AA, Berika MA, Al-Harthi MA, Kucuk O, Sahin K, Abou-
Shehema BM (2016)Laying performance, digestibility and plasma hormones in laying
hens exposed to chronic heat stress as affected by betaine, vitamin C, and/or vitamin E
supplementation. SpringerPlus 5: 1619.
Bartov I, Frigg M(1992) Effect of high concentrations of dietary vitamin E during various age
periods on performance, plasma vitamin E and meat stability of broiler chicks at 7 weeks
of age. Br Poultry Sci 33: 393-402.
BasmacıoğluMalayoğlu H, Özkan S, Koçtürk S, Oktay G, Ergül M (2009) Dietary vitamin E (α-
tocopheryl acetate) and organic selenium supplementation: performance and antioxidant
status of broilers fed n-3 PUFA-enriched feeds. S Afr J AnimSci 39: 274-285.
Bast A, Haenen GR, Doelman, CJA (1991) Oxidants and antioxidants: State of the art. Am J Med
: 1-10.
Beck MA (2007) Selenium and vitamin E status: Impact on viral pathogenicity. J Nutr 137:
-1340.
Bell DJ (1971) Plasma enzyme in physiology and biochemistry of the domestic fowl. II ed, 964-
Biswas A, Mohan J, Sastry KV (2009) Effect of higher dietary vitamin E concentrations on
physical and biochemical characteristics of semen in Kadaknath cockerels. Br PoultSci
: 733-738.
Biswas A, Mohan J, Sastry KV, Tyagi JS (2007). Effect of dietary vitamin E on the cloacal gland,
foam and semen characteristics of male Japanese quail. Theriogenology 67: 259-263.
Bollingier-Lee S, Williams PEV, Whitehead CC (1999)Optimal dietary concentration of vitamin
E for alleviating the effect of heat stress on egg production in laying hens. Br PoultSci 40:
-107.
Boxer LA (1986) Regulation of phagocyte function by alpha-tocopherol. Proc NutrSoc 45: 333-
Brandon S, Morrissey PA, Buckley DJ, Frigg M (1993) Influence of dietary a-tocopherol acetate
on the oxidative stability of chicken tissues. In: Proceedings of the 11th European
Symposium on the Quality of Poultry Meat, (Eds. P. Colin, J. Culioli and F. H. Ricard),
pp. 397-403.
Buckley DJ, Morrissey PA (1992) Animal production highlights. In: Vitamin E and Meat Quality,
Hoffmann-La Roche Ltd., Basel, Switzerland, pp. 24-27.
Buckley DJ, Morrissey PA, Gray JI (1995)Influence of dietary vitamin E on the oxidative stability
and quality of pig meat. J AnimSci73:3122-3130.
Calabrese EJ, Victor J, Stoddard MA (1985) Influence of dietary vitamin E on susceptibility to
ozone exposure. Bull Environ ContamToxicol 34: 417-422.
Carreras I, Guerrero L, Guardia MD, Esteve-GarcíaE, Garcia JA, RegueiroJA, SárragaC(2004)
Vitamin E levels, thiobarbituric acid test and sensory evaluation of breast muscles from
broilers fed α-tocopheryl acetate and β-carotene-supplemented diets. J AnimSci Food
Agric 84: 313-317.
Cheng K, Song ZH, Zheng XC, Zhang H, Zhang JF, Zhang LL, Zhou YM, Wang T (2017) Effects
of dietary vitamin E type on the growth performance and antioxidant capacity in
cyclophosphamide immunosuppressed broilers. PoultSci 96:1159-1166.
Cherian G (2015)Nutrition and metabolism in poultry: role of lipids inearly diet. J AnimSci
Biotechnol 6: 28.
Chung MK, Choi JH, Chung YK, Chee KM (2005) Effects of dietary vitamins C and E on egg
shell quality of broiler breeder hens exposed to heat stress. Asian-Aust J AnimSci
: 545-551.
Ciftci M, NihatErtas O, Guler T(2005) Effects of vitamin E and vitamin C dietary
supplementation on egg production and egg quality of laying hens exposed to a chronic
heat stress. Revue Med Vet 156:107-111.
Clegg RE, Klopfenstein CF, Klopfenstein WE (1976) Effects of diethilstilbestrol, ascorbic acid
and vitamin E on serum lipid patterns. PoultSci 55: 1104-1111.
Coetzee GJM, Hoffman LC (2001) Effect of dietary vitamin E on the performance of broilers and
quality of broiler meat during refrigerated and frozen storage. S Afr J AnimSci 31:158-
Colnago GL, Jensen LS, Long PL (1984) Effect of selenium and vitamin E on the 744 development
of immunity to coccidiosis in chickens. PoultSci 63: 1136-1143.
Colombo ML (2010) An update on vitamin E, tocopherol and tocotrienol-perspectives.
Molecules 15: 2103-2113.
Colombo ML, Corsini A,Mossa A, Sala L,Stanca M (1998) Extraction of the fat-soluble vitamin
E from Hordeum vulgare L. fruits by supercritical fluid carbon dioxide. Phytochem Anal
: 192-195.
CortinasL, BarroetaA, VillaverdeC, GalobartJ, Guardiola F, BaucellsMD (2005)Influence of
the dietary polyunsaturation level on chicken meat quality: lipid oxidation. PoultSci 84:
-55.
Dalia AM, Loh TC, Sazili AQ, Jahromi MF, Samsudin AA (2018) Effects of vitamin E, inorganic
selenium, bacterial organic selenium, and their combinations on immunity response in
broiler chickens. BMC Vet Res 14: 249.
Dalólio FS, Albino LFT, Lima HJD, Silva JN, Moreira J (2015) Heat stress and vitamin E in diets
for broilers as a mitigating measure. ActaSciAnimSci 37: 419-427.
Desoky AA (2018) Growth performance and immune response of broiler chickens reared under
high stocking density and vitamin E supplementation. Egypt PoultSci 38: 607-620.
Dietert RR, Marsh JA, Combs JR (1983) Influence of dietary selenium and vitamin E on the
activity of chicken blood phagocytes. PoultSci 62: 1412.
Donaldson WE (1982) Atherosclerosis in cholesterol fed Japanese quail: Evidence for
amelioration by dietary vitamin E. PoultSci 61: 2097-2102.
Erf GF, BottjeWG, BersiTK, HeadrickMD, FrittsCA (1998) Effects of dietary vitamin E on the
immune system in broilers: altered proportions of CD4 T cells in the thymus and spleen.
PoultSci 77: 529-537.
Evans HM, Bishop KS (1922) On the existence of a hitherto unrecognized dietary factor essential
for reproduction. Science 56: 650-651.
Fellenberg MA, Speisky H (2006) Antioxidants: their effects on broiler oxidative stress and its
meat oxidative stability. WorldsPoultSci J 62: 53-70.
Franchini A, Meluzzi A, Bertuzzi S, Giordani G (1988) High doses of vitamin E in the broilers
diets. Arch Gefügelk 52: 12-16.
Franchini, A, Giordani G, Meluzzi A, Manfreda G (1990) High doses of vitamin E in the turkey
diet. Arch Gefügelk 54: 6-10.
Fusco D, Colloca G, Monaco MRL, Cesari M (2007) Effects of antioxidant supplementation on
the aging process. ClinInterv Aging 2: 377-387.
Gao, J, Lin H, Wang XJ, Song ZG, Jiao HC (2010) Vitamin E supplementation alleviates the
oxidative stress induced by dexamethasone treatment and improves meat quality in broiler
chickens. PoultSci 89:318-327.
Gershwin M, Beach R, Hurley L (1985) The potent impact of nutritional factors on immune
response. Pages 1-7 in: Nutrition and Immunity. Academic Press, New York, NY.
Goñi I, BrenesA, Centeno C, ViverosA, Saura-CalixtoF, ReboléA, ArijaI, Estevez R (2007)
Effect of dietary grape pomace and vitamin E on growth Performance, nutrient
digestibility, and susceptibility to meat lipid oxidation in chickens. PoultSci 86:508-
Gore AB, Qureshi V (1997) Enhancement of humoral and cellular immunity by vitamin E after
embryonic exposure. PoultSci 76: 984-991.
Guetchom B, Venne D, Chénier S, Chorfi Y (2012) Effect of extra dietary vitamin E on preventing
nutritional myopathy in broiler chickens. J ApplPoult Res 21: 548-555.
Guo Y, Zhang G, Yuan J, Nie W (2003) Effects of source and level of magnesium and vitamin E
on prevention of hepatic peroxidation and oxidative deterioration of broiler meat. Anim
Feed SciTechnol 107:143-150.
Habibian M, Ghazi S, Moeini MM, Abdolmohammadi A (2014)Effects of dietary selenium and
vitamin E on immune response and biological blood parameters of broilers reared under
thermoneutral or heat stress conditions. Int J Biometeorol58:741-752.
HalliwellB (1987) Oxidants and disease: some new concepts. FASEB J 1: 358-364.
Hashizawa Y, Kubota M, Kadowaki M, Fujimura S (2013) Effect of dietary vitamin E on broiler
meat qualities, color, water‐holding capacity and shear force value, under heat stress
conditions. AnimSci J 84: 732-736.
Haq A, Bailey CA, China A (1996) Effect of carotene, canthaxanthin, lutein, and vitamin E on
neonatal immunity of chicks when supplemented in the broiler breeder diets. PoultSci 75:
-1097.
Hooda S, Tyagi PK, Mohan J, Mandal AB,Elangovan AV, Pramod KT (2007) Effects of
supplemental vitamin E in diet of Japanese quail on male reproduction, fertility and
hatchability. Br PoultSci 48: 104-110.
Ipek H, Avci M., Yerturk M, Iriadam M, Aydilek N (2007) Effects of ascorbic acid and vitamin E
on performance and hematological parameters of Japanese quails under high ambient
temperature in Sanliurfa. Arch Geflügelk 71:130- 134.
Ismail FSA, El-GogaryMr, El-Nadi MI (2014) Influence of vitamin E supplementation and
stocking density on performance, thyroid status, some blood parameters, immunity and
antioxidant status in broiler chickens. Asian J Anim VetAdv 9:702-712.
Jackson DW, Law GRJ, Nockels CE (1978) Maternal vitamin E alters passively acquired
immunity of chicks. PoultSci 57: 70-73.
Jang IS, Ko YH, Moon YS, Sohn SH (2014) Effects of vitamin C or E on the pro-inflammatory
cytokines, heat shock protein and antioxidant status in broiler chicks under summer
conditions. Asian-Aust J AnimSci 27: 749-756.
Jaradat ZW, ViI`aB, Marquardt RR (2006) Adverse effects of T-2 toxin on chicken lymphocytes
blastogenesis and its protection with Vitamin E. Toxicology 225:90-96.
Jiang W, Zhang L, Shan A (2013) The effect of vitamin E on laying performance and egg quality
in laying hens fed corn dried distillers grains with solubles. PoultSci 92: 2956-2964.
Joachim Ajakaiye J, Alcides Pérez B, Angel Mollineda T (2011). Effects of high temperature on
production in layer chickens supplemented with vitamins C and E. Rev MVZ Córdoba
:2283-2291
Kaiser MG, Block SS, Ciraci C, Fang W, Sifri M, Lamont SJ (2012). Effects of dietary
vitamin E type and level on lipopolysaccharide-induced cytokine mRNA expression in
broiler chicks. PoultSci 91: 1893-1898.
Karadas F, Møller AP, Karageçili MR (2017) A comparison of fat-soluble antioxidants in wild
and farm-reared chukar partridges (Alectorischukar). Comp BiochemPhysiolMolIntegr
Physiol 208: 89-94.
Kennedy DG, Rice DA, Bruce EA, Goodall EA, McIlroy SG(1992) Economic effects of increased
vitamin E supplementation of broiler diets on commercial broiler production. Br PoultSci
: 1015-1023.
Khan RU (2011) Antioxidants and poultry semen quality. World's PoultSci J 67: 297-308.
Khan MZ, Akter SH, Islam MN, Karim MR, Islam MR, Kon Y (2008) The effect of selenium and
vitamin E on the lymphocytes and immunoglobulin-containing plasma cells in the
lymphoid organ and mucosa-associated lymphatic tissues of broiler chickens. AnatHistol
Embryol 37: 52-59.
Khan RU, Rahman ZU, NikousefatZ, JavdaniM, TufarelliV, Dario C, Selvaggi, M, LaudadioV
(2012a)Immunomodulating effects of vitamin E in broilers. World’s PoultSci J 68:31-
Khan RU, Rahman ZU, Javed I, Muhammad F (2012b) Effect of vitamins, probiotics and protein
on semen traits in post-molt male broiler breeders. AnimReprodSci 135: 85-90.
Khan RU, Rahman ZU, Javed I, Muhammad F (2014) Effect of vitamins, protein level and
probiotics on immune response of moulted male broiler breeders. J AnimPhysiolAnim
Nutr 98: 620-627.
Khan SA, Khan A, Khan SA, Beg MA, Ali A, DamanhouriG (2017) Comparative study of fatty-
acid composition of table eggs from the jeddah food market and effect of value addition in
omega-3 bio-fortified eggs. Saudi JBiolSci 24: 929-935.
Kim ES, Noh SK, Koo SI(1998)Marginal zinc deficiency lowers the lymphatic absorption of α-
tocopherol in rats. J Nutr128: 265-270.
Kirunda D, Scheideler S (2001)The efficacy of vitamin E (DL-α-tocopheryl acetate)
supplementation in hen diets to alleviate egg quality deterioration associated with high
temperature exposure. PoultSci 80: 1378-1383.
Konieczka P, Barszcz M, Chmielewska N, Cieślak M, Szlis M, Smulikowska S (2017)
Interactive effects of dietary lipids and vitamin E level on performance, blood eicosanoids,
and response to mitogen stimulation in broiler chickens of different ages. PoultSci 96:
-369.
Konjufca VK, Bottje WG, Bersi TK, Erf GF (2004) Influence of dietary vitamin E on phagocytic
functions of macrophages in broilers. PoultSci 83: 1530-1534.
Kucuk O, Kahraman A, Kurt I, Yildiz N, Onmaz A(2008)A combination of zinc and pyridoxine
supplementation to the diet of laying hens improves performance and egg quality.Biol
Trace Elem Res 126: 165-175.
Kuttappan VA, Goodgame SD, Bradley CD, MauromoustakosA, Hargis BM, WaldroupPW,
Owens CM (2012) Effect of different levels of dietary vitamin E (dl-α-tocopherol acetate)
on the occurrence of various degrees of white striping on broiler breast fillets. PoultSci
: 3230-3235.
Lee GY, Han SN (2018) The role of vitamin E in immunity. Nutrients 10: 1614.
Leshchinsky TV, Klasing KC (2001) Relationship between the level of dietary vitamin E and the
immune response of broiler chickens. PoultSci 80: 1590-1599.
Leshchinsky TV, Klasing KC (2003) Profile of chicken cytokines induced by lipopolysaccharide
is modulated by dietary alpha-tocopheryl acetate. PoultSci 82(8): 1266-1273.
Levander OA, Morris VC, Ferretti RJ (1977) Comparative effects of selenium and vitamin E in
lead-poisoned rats. J Nutr 107: 378-382.
Lin YF, Chang SJ (2006) Effect of dietary vitamin E on growth performance and immune response
of breeder chickens. Asian-Aust J AnimSci 19: 884-891.
Lin YF, Chang SJ, Hsu AL (2004) Effects of supplemental vitamin E during the laying period on
the reproductive performance of Taiwan native chickens. Br PoultSci 45: 807-814.
Liu X, Byrd JA, Farnell M, Feria RCA (2014) Arginine and vitamin E improve the immune
response after a Salmonella challenge in broiler chicks. PoultSci 93: 882-890.
Liu YJ, Zhao LH, Mosenthin R, Zhang JY, Ji C, Ma QG (2019) Protective effect of vitamin E on
laying performance, antioxidant capacity, and immunity in laying hens challenged with
Salmonella enteritidis. PoultSci 98: 5847-5854.
Lohakare JD, Choi JY, Kim JK, Yong JS, Shim YH, Hahn TW, ChaeBJ (2005) Effects of dietary
combinations of vitamin A, E and methionine on growth performance, meat quality and
immunity in commercial broilers. Asian-Aust J AnimSci 18: 516-523.
Lu T, Harper AF, Zhao J, Dalloul RA (2014) Effects of a dietary antioxidant blend and vitamin E
on growth performance, oxidative status, and meat quality in broiler chickens fed a diet
high in oxidants. PoultSci 93: 1649-1657.
Machlin LJ(1991) Vitamin E. Pages 99–144 in Handbook of Vitamins. L. J. Machlin, ed. Marcel
Dekker, New York, NY.
March BE, Wong E, Seier L, Sim J, Biely J (1973) Hypervitaminosis E in the chick. JNutr 103:
-377.
Marsh JA, Combs JR, Whitacre ME, Dietert RR (1986) Effect of selenium and vitamin E dietary
deficiencies on chick lymphoid organ development. ProcSociExperimBiolMed 182: 425-
McCuaig LW, Motzok I (1970) Excessive dietary vitamin E: Its alleviation of hypervitaminosis A
and lack of toxicity. PoultSci 49:1050-1052.
McDowell LR(2012)Vitamins in Animal Nutrition: Comparative Aspects to Human Nutrition;
Elsevier: Amsterdam, The Netherlands.
McIlroy SG, Goodall EA, Rice DA, McNulty MS, Kennedy DG (1993) Improved performance in
commercial broiler flocks with subclinical infectious bursal disease when fed diets
containing increased concentrations of vitamin E. Avian Pathol 22: 81-94.
Michalczuk M, Damaziak K, Niemiec J (2016) Dietary vitamin E supplementation on cholesterol,
vitamin E content, and fatty acid profile in chicken muscles. Can J AnimSci 120: 114-120.
Morrissey PA, Buckley DJ, Sheehy PJ, Monahan FJ (1994) Vitamin E and meat quality. Proc Nutr
Soc 53:289-295.
Murphy TP, Wright KE, PudelKiewicz WJ (1981) An apparent effect of excessive vitamin E in
the chick. PoultSci 60: 1873-1878.
Narimany-Rad M, Nobakht A. Aghdam-shahyarH, Lotfi AR (2011)The effects of dietary
National Research Council (1994). Nutrient requirements of poultry. National Academic
Press, Washington, DC. USA.
Nawab A, Ibtisham F, Li G, Kieser B, Wu J, Liu W, Zhao Y, Nawab Y, Li K, Xiao M, An L (2018)
Heat stress in poultry production: mitigation strategies to overcome the future challenges
facing the global poultry industry. J ThermBiol 78: 131-139.
Niu ZY, Liu FZ, Yan QL, Li WC (2009) Effects of different levels of vitamin E on growth
performance and immune responses of broilers under heat stress. PoultSci 88: 2101-2107.
Nobakht A (2012)The effects of different levels of poultry fat with vitamin E on performance and
carcass traits of broilers. Afr J AgricRes 7: 1420-1424.
National Research Council (NRC) (1994) Nutrient requirements of domestic animals. 9th ed.
Washington, DC.
Onderci M, Sahin N, SahinK, Kilic N (2003)Antioxidant properties of chromium and zinc.
Biol Trace Elem Res 92: 139-149.
Packer L, Suzuki YJ (1993) Vitamin E and alpha-lipoate: role in antioxidant recycling and
activation of the NF-kappa B transcription factor. Mol Aspects Med 14: 229-239.
Pal M (2017) The role of minerals and vitamins in poultry production. Agric World, 3.
Panda AK, Cherian G (2014) Role of vitamin E in counteracting oxidative stress in poultry. J
PoultSci 51:109-117.
Parolini M, Romano M, Caprioli M, Rubolini D, Saino N (2015) Vitamin E deficiency in last-
laid eggs limits growth of yellow-legged gull chicks. FunctEcol 29: 1070-
Pekmezci D (2011) Vitamin E and immunity. VitamHorm 86: 179-215.
Perez-Carbajal C, Caldwell D, Farnell M, StringfellowK, Pohl S, Casco G, Pro-Martinez A,
Ruiz-Feria CA (2010). Immune response of broiler chickens fed different levels of
arginine and vitamin E to a coccidiosis vaccine and Eimeria challenge. PoultSci 89:
-1877.
PitargueFM, Kim JH, Goo D, Reyes JBD, KilDY (2019) Effect of vitamin E sources and
inclusion levels in diets on growth performance, meat quality, alpha-tocopherol retention,
and intestinal inflammatory cytokine expression in broiler chickens. PoultSci 98:
-4594.
PirgozlievVR, MansbridgeSC, Westbrook CA, Woods SL, Rose SP, Whiting IM, YovchevDG,
AtanasovAG, KljakK, StaykovaGP, IvanovaSG, KarakeçiliMR, KaradaşF, Stringhini
JH (2020) Feeding dihydroquercetin and vitamin E to broiler chickens reared at standard
and high ambient temperatures. Arch AnimNutr 74: 96-511.
Pompeu MA,Cavalcanti LFL, ToralFLB (2018) Effect of vitamin E supplementation on growth
performance, meat quality, and immune response of male broiler chickens: A meta-
analysis. LivestSci208: 5-13.
Puthpongsiriporn U, ScheidelerSE, Sell JL, Beck MM(2001) Effects of vitamin E and C
supplementation on performance, in vitro lymphocyte proliferation, and antioxidant status
of laying hens during heat stress. PoultSci80: 1190-1200.
Raederstorff D, Wyss A, Calder PC, Weber P, Eggersdorfer M (2015) Vitamin E function and
requirements in relation to PUFA. Br J Nutr 114: 1113-1122.
Rajmane BV, RanadeAS (1994) Effect of dietary vitamin E and C on growth and immune
response of broilers. Ind J PoultSci29: 78.
ReboléA, Rodri´guezML, Ortiz LT, AlzuetaC, Centeno C, ViverosA, BrenesA, ArijaI(2006)
Effect of dietary high-oleic acid sunflower seed, palm oil and vitamin E supplementation
on broiler performance, fatty acid composition and oxidation susceptibility of meat. Br
PoultSci47: 581-591.
Rengaraj D, Kwon WS, Pang MG (2015) Effects of motor vehicle exhaust on male reproductive
function and associated proteins. J Proteome Res 14: 22-37.
Rey AI, Segura J, Olivares A, CerisueloA, Pi˜neiroC,L´opez-BoteCJ (2015) Effect of micellized
natural (D-α-tocopherol) vs. synthetic (DL-α-tocopheryl acetate) vitamin E
supplementation given to turkeys on oxidative status and breast meat quality characteristic.
PoultSci 94:1259-1269.
Richard D, Kefi K, Barbe U, Bausero P, Visioli F (2008) Polyunsaturated fatty acids as
antioxidants. Pharmacol Res 57: 451-455.
Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F (2014) The role of vitamin e in human
health and some diseases. Sultan QaboosUniv Med J 14: e157-165.
Sahin K, Kucuk O(2001) Effects of vitamin C and vitamin E on performance, digestion of
nutrients and carcass characteristics of Japanese quails reared under chronic heat stress
(34°C). J AnimPhysiolAnimNutr 85:335-341.
Sahin K, Kucuk O (2003)Zinc supplementation alleviates heat stress in laying Japanese quail. J
Nutr 133: 2808-2811.
Sahin K, Sahin N, Yaralioglu S (2002a) Effects of vitamin C and vitamin E on lipid peroxidation,
blood serum metabolites and mineral concentrations of laying hens reared at high ambient
temperature. Biol Trace Elem Res 85:35-45.
Sahin K, Kucuk O, Sahin N, Gursu MF (2002b) Optimal dietary concentration of vitamin E for
alleviating the effect of heat stress on performance, thyroid status, ACTH and some serum
metabolite and mineral concentrations in broilers. Vet Med 47: 110-116.
Sahin K, Sahin N, Onderci M,Yaralioglu S,Kucuk O (2001)Protective role of supplemental
vitamin E on lipid peroxidation, vitamins E, A and some mineral concentrations of broilers
reared under heat stress. Vet Med (Praha) 46: 140-144.
Sahin K, Sahin N, Onderci M, Gursu MF, Issi M(2003) Vitamin C and E can alleviate negative
effects of heat stress in Japanese quails. Food Agric Environ 1: 244-249.
Salgueiro MJ, Zubillaga M, Lysionek A, Sarabia MI, Caro R, De Paoli T, Hager A, Weill R, Bocci
J (2000) Zinc as an essential micronutrient: A review. Nutr Res 20: 737-755.
SermanV, Mas N, Mazija H, Mikulec Z (1992) Immune response as a marker of needs for vitamin
E in chickens. 2.The influence of Vitamin E on fattening chicks productivity. Krimva 34:
-69.
Sheehy PJA, Morrissey PA, Flynn A (1993) Influence of heated vegetable oils and alpha-
tocopherol acetate supplementation on alpha-tocopherol, fatty acids and lipid peroxidation
in chicken muscle. BrPoultSci 34: 367-381.
Sheffy BE, Schultz RD (1979) Influence of vitamin E and selenium on immune response
mechanisms. Feed Processing 38: 2139-2143.
Sheldon BW, Curtis PA, Dawson PL, Ferket PR (1997) Effect of dietary vitamin E on the oxidative
stability, flavour, colour and volatile profiles of refrigerated and frozen turkey breast meat.
PoultSci 76: 634-641.
Singh H, Sodhi S, Kaur R (2006) Effects of dietary supplements of selenium, vitamin E or
combinations of the two on antibody responses of broilers. Br PoultSci 47:714-719.
Silva ICM, Ribeiro AML, Canal CW, Vieira MM, Pinheiro CC, Gonçalves T, de MoraesML,
Ledur VS (2011) Effect of vitamin E levels on the cell-mediated immunity of broilers
vaccinated against coccidiosis. Braz J PoultSci 13: 53-56.
Sklan D, Donoghue S (1982) Vitamin E response to high dietary vitamin A in the chick. JNutr
: 759-765.
Smith TL, Kummerow FA (1989) Effect of dietary vitamin E and plasma lipids anatherogenesis
in restricted ovulation chickens. Atherosclerosis 75: 105-109.
Sonam K,Guleria S (2017)Synergistic antioxidant activity of natural products. AnnalPharmacol
Pharm 2: 1086.
Sosnowka-Czajka E, Skomorucha I, HerbutE (2005) Effect of dietary vitamin supplements on
productivity and physiological parameters of broiler chickens exposed to elevated ambient
temperature. Warsaw, Poland: ISAH; 2005.
Surai PF (2020) Antioxidants in poultry nutrition and reproduction: An update. Antioxidants
(Basel) 9:105.
Surai PF, Kochish II (2019) Nutritional modulation of the antioxidant capacities in poultry: The
case of selenium. PoultSci 98: 4231-4239.
Surai PF, Kochish II, Romanov MN, Griffin DK (2019) Nutritional modulation of the antioxidant
capacities in poultry: The case of vitamin E. PoultSci 98: 4030-4041.
Traber MG, Atkinson J (2007) Vitamin E, antioxidant and nothing more. Free RadicBiol Med43:
-15.
Tufarelli V, Laudadio V (2016) Antioxidant activity of vitamin E and its role in avian reproduction.
J ExperimBiolAgricSci 4: 267-272.
Villar-Patino G, Díaz-Cruz A, Avila-González E, Guinzberg R, Pablos JL, Piña E (2002) Effects
of dietary supplementation with vitamin C or vitamin E on cardiac lipid peroxidation and
growth performance in broilers at risk of developing ascites syndrome. Am J Vet Res 63:
-676.
Yang H, Mahan DC, Hill DA, Shipp TE, RadkeTR, CecavaMJ (2009) Effect of vitamin E source,
natural versus synthetic, and quantity on serum and tissue {alpha}-tocopherol
concentrations in finishing swine. J AnimSci 87:4057-4063.
Yesilbag D, Eren M, Agel H, Kovanlikaya A, Balci F (2011)Effects of dietary rosemary, rosemary
volatile oil and vitamin E on broiler performance, meat quality and serum SOD activity.
Br PoultSci 52:472-482.
Zhang XH, ZhongX, Zhou YM, Wang GQ, Du HM, Wang T (2010) Dietary RRR-a-tocopherol
succinate attenuates lipopolysaccharide-induced inflammatory cytokines secretion in
broiler chicks. Brit J Nutr 104:1796-1805.
Zhao GP, Han MJ, Zheng MQ, Zhao JP, Chen JL, Wen J (2011) Effects of dietary vitamin E on
immunological stress of layers and their offspring. J AnimPhysiolAnimNutr (Berl). 95:
-350.
