General Properties of Propolis and its Usage in Ruminants

Published: Ιουλ 9, 2022
Propolis ruminants feed additive antibiotics immunomodulatory
VF Özdemir
M Yanar

Propolis is a product with many benefits, honey bees produce propolis by mixing the resin substances they collect from the bark, leaves, and plant secretions of trees with honey, wax, pollen, and their salivary enzymes. They use this product for several purposes including protecting bee larvae, honey stores, and honeycombs from infections, repairing damaged areas, covering holes and cracks in the hive. It was also used in folk medicine with its antimicrobial and healing effects since ancient times. Beside these properties, with the advancements in science, various other properties of propolis like immunomodulatory, anti-inflammatory, antitumor, antioxidant, anticarcinogenic, antiprotozoal, antiviral, antiulcer, local anesthetic, cytotoxic, and many more were also discovered. When it was discovered that antibiotics create residues in foods and cause resistance in some microorganisms, the use of antibiotics in farm animals has been restricted in many countries. This led to an increase in the demand for organic products in the public and drove scientists to search for new natural alternative feed additives that can show similar effects with antibiotics in order to prevent economic losses caused by the restriction. In this study, it was aimed to discuss the effects of propolis in ruminants as a feed additive and its usability as a natural alternative to antibiotics by analyzing studies on the field.

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Author Biography
Rıdvan KOÇYİĞİT, Atatürk University
Animal Science
Abd-Allah M, Daghash MWH (2019) Influence of Using Flavomycin and Propolis as Feed Additives on Buffalo Milk Production, and Growth Performance and Blood Metabolites of Suckling Calves. Egypt. J. Nutr. and Feeds 22(1):13-22.
Abdulkhani A, Hosseinzadeh J, Ashori A, Esmaeeli H (2017) Evaluation of the antibacterial activity of cellulose nanofibers/polylactic acid composites coated with ethanolic extract of propolis. Polym Compos 38(1):13-19.
Aguiar SCD, De Paula EM, Yoshimura EH, Dos Santos WBR, Machado E, Valero MV, Dos Santos GT, Zeoula LM (2014) Effects of phenolic compounds in propolis on digestive and ruminal parameters in dairy cows, Rev. Bras. de Zootec.. 43(4):197-206.
Al-Ani I, Zimmermann S, Reichling J, Wink M (2018) Antimicrobial activities of European propolis collected from various geographic origins alone and in combination with antibiotics. Medicines 5(1): 2.
Anjum SI, Ullah A, Khan KA, Attaullah M, Khan H, Ali H, Bashir MA, Tahir M, Ansari MJ, Ghramh HA, Adgaba N (2019) Composition and functional properties of propolis (bee glue): A review. Saudi J. Biol. Sci. 26(7):1695-1703.
Anonymous (2014) Antimicrobial resistance global report on surveillance. World Health Organization, Geneva 27, Switzerland.
Bankova VS, de Castro SL, Marcucci MC (2000) Propolis: recent advances in chemistry and plant origin. Apidologie 31(1):3-15.
Banskota AH, Tezuka Y, Adnyana IK, Midorikawa K, Matsushige K, Message D, Huertas AA, Kadota S (2000) Cytotoxic, hepatoprotective and free radical scavenging effects of propolis from Brazil, Peru, the Netherlands and China. J. Ethnopharmacol. 72(1-2): 239-246.
Cécere BG, da Silva AS, Molosse VL, Alba DF, Leal KW, da Rosa G, Pereira WAB, da Silva AD, Schetinger MRC, Kempka AB, Nunes A, Maraschin M, Araújo DN, Deolindo GL, Vedovatto M (2021) Addition of propolis to milk improves lactating lamb’s growth: Effect on antimicrobial, antioxidant and immune responses in animals. Small Ruminant Res. 194:106265.
Commission E.U. (2005) Ban On Antibiotics As Growth Promoters İn Animal Feed Enters İnto Effect (1831/2003/EC) In: Safety. Ef (Ed.), Europa, Brussels.
Erhan MK (2015) Evelation of Herbal Extracts which are Used as an Alternative to Antibiotics in Poultry Feeding on Performance Values and in Terms of some Parametres. Alinteri Journal of Agricultural Science 28(1): 45-54.
Eroğlu Ö, Yüksel S (2020)Propolis From Past To Present. Journal of Social, Humanities and Administrative Sciences, 6(26):623-629.
Foster DM, Smith GW (2009) Pathophysiology of diarrhea in calves. Vet. Clın. N. Am-Food A. 25(1): 13-36.
Hayashi K, Komura S, Isajı N, Ohıshı N, Yagı K (1999) İsolation of antioksidative compounds from Brazilian propolis: 3, 4-dihydroxy-5-prenylcinnamic acid, a novel potent antioxidant. Chem. Pharm. Bull. 47 (11):1521-1524.
Kozat S (2019) The Importance of Colostrum Management in Newborn Calves. Atatürk University J Vet Sci 14(3):343-353.
Kupczyński R, Adamski M, Falta D, Roman A (2012) The efficiency of propolis in post-colostral dairy calves. Arch. Anim. Breed. 55(4): 315-324.
Kuppusamy S, Kakarla D, Venkateswarlu K, Meghara M, Yoon YE, Lee YB (2018) Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view. Agric. Ecosyst. Environ 257:47-59.
Machado B, Pulcino TN, Silva AL, Tadeu D, Melo RGS, Mendonça IG (2017) Propolis as an alternative in prevention and control of dental cavity. Immunity 19:24.
Manav S, Yilmaz M, Baytekin H, Çelik K, Çağli A (2020) The use of propolis as an antimicrobial in livestock-an overview. Agric. Sci. Technol. 12(3):205-209.
Marcucci MC, Ferreres F, García-Viguera C, Bankova VS, De Castro SL, Dantas AP, Valente PHM, Paulino N (2001) Phenolic compounds from Brazilian propolis with pharmacological activities. J. Ethnopharmacol. 74:105–112.
Martinotti S, Ranzato E (2015) Propolis: a new frontier for wound healing? Burns Trauma 3(1):1-7.
Morsy A, Soltan, YA, Sallam SMA, Kreuzer M, Alencar SM, Abdalla AL (2015) Comparison of the in vitro efficiency of supplementary bee propolis extracts of different origin in enhancing the ruminal degradability of organic matter and mitigating the formation of methane. Anim. Feed Sci. Technol. 199:51-60.
Morsy AS, Soltan YA, Sallam SM, Alencar SM, Abdalla AL (2016) Impact of Brazilian red propolis extract on blood metabolites, milk production, and lamb performance of Santa Inês ewes. Trop. Anim. Health Prod. 48(5):1043-1050.
Morsy AS, Soltan YA, El-Zaiat HM, Alencar SM, Abdalla AL (2021) Bee propolis extract as a phytogenic feed additive to enhance diet digestibility, rumen microbial biosynthesis, mitigating methane formation and health status of late pregnant ewes. Anim. Feed Sci. Technol. 273:114834.
Muktar Y, Mamo G, Tesfaye B, Belina D (2015) A review on major bacterial causes of calf diarrhea and its diagnostic method. J. Vet. Med. Anim. Health 7(5):173-185.
Okonenko LB (1988) Salmonella infections and propolis. Zdravookhr. Kaz. 1:55-57.
Ota C, Unterkircher C, Fantinato V, Shimizu MT (2001) Antifungal activity of propolis on different species of candida. Mycoses 44(9-10):375-378.
Ozturk H, Pekcan M, Sireli M, Fidanci UR (2010) Effects of propolis on in vitro rumen microbial fermentation. Vet J Ankara Univ 57(1):217–221.
Prado OPPD, Zeoula LM, Moura LPPD, Franco SL, Paiva SBD, Arcuri PB (2010) Isolation and expeditious morphological, biochemical and kinetic characterization of propolis-tolerant ruminal bacteria. Rev. Bras. de Zootec. 39(9):2048-2054.
Sabir A, Sumidarti A (2017) Interleukin-6 expression on inflamed rat dental pulp tissue after capped with Trigona sp. propolis from south Sulawesi, Indonesia. Saudi J. Biol. Sci. 24(5):1034-1037.
Sarker MSK, Yang CJ (2010) Propolis and illite as feed additives on performance and blood profiles of pre-weaning Hanwoo calves. J Anim Vet Adv 9(19):2526-2531.
Seif DJ, Seifzadeh S, Abdi BH, Mirzai AGF (2017) The Effects of Propolis Extract on Growth Performance, Blood Parameters and Antioxidant Status in Holstein Suckling Calves. J. Anim. Phsiol. Dev. 10(3):43-53
Seven İ, Aksu T, Seven PT (2007) Propolis ve hayvan beslemede kullanımı. Van Vet J (2):79-84.
Sforcin JM (2016) Biological properties and therapeutic applications of propolis. Phytother Res 30(6):894-905.
Shedeed HA, Farrag B, Elwakeel EA. El-Hamid ISA. El-Rayes MAH (2019) Propolis supplementation improved productivity, oxidative status, and immune response of Barki ewes and lambs. Vet. World 12:834–843.
Siheri W, Alenezi S, Tusiimire J, Watson DG (2017) The chemical and biological properties of propolis. In Bee products-chemical and biological properties (pp. 137-178). Springer, Cham.
Silici S, Kutluca S (2005) Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. J. Ethnopharmacol. 99(1):69-73.
Simu'th J, Trnovský J, Jelokova J (1986) Inhibition of bacterial DNA-dependent RNA polymerases and restriction endonuclease by UV-absorbing components from propolis. Die Pharmazie 41(2):131-132.
Slanzon G, Toledo AF, Silva AP, Coelho MG, Silva MD, Cezar AM and Bittar CMM (2019) Red propolis as an additive for preweaned dairy calves: Effect on growth performance, health, and selected blood parameters. J. Dairy Sci. 102:8952-8962.
Soltan YA, Morsy AS, Sallam SMA, Hashem NM, Abdalla AL (2016) Propolis as a natural feed additive in ruminant diets; can propolis affect the ruminants performance?; A review. EJNF 19(1):73-79.
Soltan Y, Patra A (2020).Bee Propolis as a Natural Feed Additive: Bioactive Compounds and Effects on Rumınal Fermentation Pattern as well as Productivity of Ruminants. Indian J. Anim. Hlth. 59(2):50-61.
Stradiotti Junior D, Queiroz AC, Lana RP, Pacheco CG, Eifert EC, Nunes PMM (2004) Effect of the propolis on amino acids deamination and ruminal fermentation, Rev. Bras. de Zootec. 33(4):1086-1092.
Sung SH, Choi GH, Lee NW, Shin BC (2017) External use of propolis for oral, skin, and genital diseases: a systematic review and meta-analysis. Evid.-Based Complementary Altern. Med. 2017.
Şahal M, Terzi OS, Ceylan E, Kara E (2017) Buzağı İshalleri ve Korunma Yöntemleri. Lalahan Hay. Araşt. Enst. Derg. 58(3):41-49.
Şen Y (2020) Etlik piliç rasyonlarında farklı kimyon düzeylerinin performans ve bazı kan parametreleri üzerine etkisi. Master's thesis (Printed) Afyon Kocatepe Üniversitesi, Sağlık Bilimleri Enstitüsü.
Taluğ AM, Özkul H (1999) Ruminantların beslenmesinde iyonofor kullanımı. Hay. Üret. 40(1):72-80.
Toreti VC, Sato HH, Pastore GM, Park YK (2013) Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evid.-Based Complementary Altern. Med. 2013.
Wagh VD (2013) Propolis: a wonder bees product and its pharmacological potentials. Adv Pharmacol Sci 2013:308249.
Wollenweber E, Hausen BM, Greenaway W (1990) Phenolic constituents and sensitizing properties of propolis, poplar balsam and balsam of Peru. Bull. de Liaison-Groupe Polyphenols 15:112-120.
Veiga RS, De Mendonça S, Mendes PB, Paulino N, Mimica MJ, Lagareiro Netto A, Lira IS, López BC, Negrão V, Marcucci MC (2017) Artepillin C and phenolic compounds responsible for antimicrobial and antioxidant activity of green propolis and Baccharis dracunculifolia DC. J. Appl. Microbiol 122(4):911-920.
Vynograd N, Vynograd I, Sosnowski Z (2000) A comparative multicentre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine (7):1-6.
Yonar ME (2017) General Properties of Propolis and Usage in Fish. TURJAF (9):1015-1023.
Yılmaz L, Yılsay TÖ, Bayizit AA (2004) Propolisin Kimyasal Bileşimi, Biyolojik Özellikleri ve İnsan Sağlığı Üzerine Etkisi. Gıda ve Yem Bilimi Teknolojisi Dergisi (6).
Yumnam R, Nandan N, Kumar NC, Raj S, Mannepalli A (2017) Effect of propolis in oral health. JAIMS 2(1):186-192.
Yücel B, Topal E, Akçiçek E, Köseoğlu M (2014) Propolisin insan sağlığına etkileri. Anadolu Journal of AARI 24(2):41-49.
Yücel B, Önenç A, Kaya A, Altan Ö (2015) Effects of propolis administration on growth performance and neonatal diarrhea of calves. SOJ Veterinary Sciences 1(1):102-106.
Zawadzki F, Prado IN, Marques JA, Zeoula LM, Rotta PP, Sestari BB, Valero MV, Rivaroli D C (2011) Sodium monensin or propolis extract in the diets of feedlot-finished bulls: effects on animal performance and carcass characteristics. J. Anim. Feed Sci. 20(1):16-25.
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