The Relationship of Clinicopathological Parameters and Formula for Predicting Malondialdehyde Level in Feline Immunodeficiency Virus (FIV) - infected Cats

PDF
Published: Jul 10, 2022
DOI: https://doi.org/10.12681/jhvms.26687
Keywords:
FIV clinicopathology malondialdehyde total antioxidant power cat
Kanissarinn Sakundech
https://orcid.org/0000-0003-3978-7317
Worapol Aengwanich
https://orcid.org/0000-0002-7547-0213
Abstract

The objective of this study was to investigate clinicopathological parameters, malondialdehyde and total antioxidant power for analyzing correlation and predicting malondialdehyde in plasma of feline immunodeficiency virus (FIV)-infected cats. Body condition score (BCS), mucous membrane color score (MMCS), vital signs, hematological parameters, malondialdehyde and ferric reducing antioxidant power (FRAP) of 20 FIV-infected cats were examined. The correlation and multiple regression model were then analyzed. The results revealed the following. The correlation between hemoglobin vs. packed cell volume (PCV), total red blood cell (TRBC) vs. PCV, TRBC vs. hemoglobin, mean corpuscular hemoglobin (MCH) vs. mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) vs. MCH, body temperature vs. eosinophil, total white blood cell (TWBC) vs. eosinophil, MMCS vs.  platelet, eosinophil vs. malondialdehyde, PCV vs. FRAP, hemoglobin vs. FRAP, TRBC vs. FRAP and TRBC vs. FRAP were significantly positive correlated between pairs of these parameters (P<0.05), while body temperature vs. MCV, TRBC vs. MCV, heart rate vs. platelet, heart rate vs. platelet were significantly negatively correlated between pairs of parameters (P<0.05). A formula for predicting malondialdehyde was Heart Rate (beats/minute) = 166.341 + 5.438*Hemoglobin (g/dl) + 0.0009*Total White Blood Cell (cell/ml) - 1152.48*Malondialdehyde (µmol/ml) (MSE=132.2540; r2=0.85). These results indicated that there were correlations between some clinicopathological parameters, malondialdehyde and total antioxidant power and a formula for predicting malondialdehyde levels in plasma of FIV-infected cat was obtained.

Article Details
  • Section
  • Research Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
References
Alam MM, Hashem MA, Rahman MM, Hossain MM, Haque MR, Sobhan Z, Islam MS (2011) Effect of heat stress on behavior, physiological and blood parameters of goat. Progress Agric 22(1-2): 37–45.
Ayala A, Muñoz MF, Argüelles S (2014) Lipid peroxidation: Production, metabolism,
and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal. Oxid Med Cell Longev. Volume 2014, Article ID 360438
Benzie IFF, Strain JJ (1996) The rerric reducing ability of plasma (FRAP) as a
measure of ‘‘antioxidant power’’: The FRAP assay. Anal Biochem 239: 70–76.
Bjornvad CR, Nielsen DH, Armstrong PJ, McEvoy F, Hoelmkjaer KM, Jensen KS, Pedersen
GF, Kristensen AT (2011) Evaluation of a nine-point body condition scoring system
in physically inactive pet cats. Am J Vet Med Res 72: 433–437.
Boyd BM, Mader TL, Bittner CJ, Burken DB, Hilscher FH, Wijffels G, Gaughan JB, Sullivan
ML, Cawdell- Smith AJ, Erickson GE (2016). Metabolic and Body Temperature Responses to Environmental Conditions Across Seasons in Finishing Steers. Nebraska Beef Cattle Reports. Paper 861.
Brekke IJ, Puntervoll LH, Pedersen PB, Kellett J, Brabrand M (2019) The value of vital sign trends in predicting and monitoring clinical deterioration: A systematic review. PLoS One 14 (1): e0210875. https://doi.org/10.1371/journal. pone.0210875
Duguma A (2016) Practical manual on veterinary clinical diagnostic approach. J Vet Sci Technol 7: 337. https: //doi:10.4172/2157-7579.1000337
Englar RE (2019) Common Clinical Presentations in Dogs and Cats, John Wiley & Sons, Inc, New Jersey.
Humm K, Kellett-Gregory L (2016) Monitoring Small Animal Patients in the Intensive Care
Unit. In Pract 38 (Suppl 4): 12–17.
Hwang J, Gottdenker N, Min MS, Lee H, Chun MS (2015) Evaluation of biochemical and haematological parameters and prevalence of selected pathogens in feral cats from urban and rural habitats in South Korea. J Feline Med Surg 2015: 1–9. https://doi: 10.1177/1098612X15587572
Kayar A, Dokuzeylul B, Kandemir FM, Kirbas A, Bayrakal A, Or ME (2015) Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus. Vet Med-Czech 60: 274–281.
Levy JK, Nutt K, Tucker SJ (2015) Reference interval for rectal temperature in healthy confined adult cats. J Feline Med Surg 17: 950–952.
Lim CSH, Lim SL (2013) Ferric reducing capacity versus ferric reducing antioxidant power for
measuring total antioxidant capacity. Lab Med 44: 51–55.
McManus C, Paludo GR, Louvandini H, Gugel R, Sasaki LCB, Paiva SR (2009) Heat tolerance in Brazilian sheep: Physiological and blood parameters. Trop Anim Health Prod 41: 95–101.
Miller C, Boegler K, Carver S, MacMillan M, Bielefeldt-Ohmann H, VandeWoude S (2017) Pathogenesis of oral FIV infection. PLoS One 12 (9): e0185138. https://doi.org/10.1371/journal. pone.0185138
Mostafa M, Ferdousi S, Sultana S, Akhter A (2019) Autonomic impairment and oxidative stress: Relationship in PCOS patients. J Bangladesh Soc Physiol 14: 82–88.
Norkus CL (2019). Veterinary Technician’s Manual for Small Animal Emergency and Critical Care. 2ed, Wiley Blackwell, PA.
Ozdemir O, Alyan MSO, Geyik B, Demir AD, Aras D, Cihan G, Cagirci G, Kacmaz F, Balbay Y, Sasmaz H, Korkmaz S (2004) Association between mean platelet volume and autonomic nervous system functions: Increased mean platelet volume reflects sympathetic overactivity. Exp Clin Cardiol 9: 243–247.
Sand C, Englert T, Egberink H, Lutz H, Hartmann K (2010) Evaluation of a new in-clinic test
system to detect feline immunodeficiency virus and feline leukemia virus infection. Vet Clin Pathol 39: 210–214.
Sapowicz SA, Linder DE, Freeman LM (2016) Body condition scores and evaluation of feeding habits of dogs and cats at a low cost veterinary clinic and a general practice. Sci World J Article ID 1901679
Taylor SM (2020) Small Animal Clinical Techniques, Elsevier, Missouri.
Teixeira CC, Boaventura RP, Souza ACS, Paranaguá TT de B, Bezerra ALQ,
Bachion MM, Brasil VV (2015) Vital signs measurement: An indicator of safe care delivered to elderly patients. Texto Contexto Enferm 24: 1071–1078.
Teng KT, McGreevy PD, Toribio JAML, Raubenheimer D, Kendall K, Dhand NK (2018) Strong associations of nine-point body condition scoring with survival and lifespan in cats. J Feline Med Surg 20: 1110–1118.
Tiwari LM, Kotwal CJ, Kotwal A, Mishra MP, Dutta BV, Chopra BS (2013) Correlation of haemoglobin and red cell indices with serum ferritin in Indian women in second and third trimester of pregnancy. Med J Armed Forces India 69: 31–36.
Turkson PK, Ganyo EY (2015) Relationship between haemoglobin concentration and packed cell volume in cattle blood samples. Onderstepoort J Vet Res 82(1), 863.
Velguth KE, Payton ME, Hoover JP (2010) Relationship of hemoglobin concentration to packed cell volume in avian blood samples. J Avian Med Surg 24: 115–121.
Wang P, Ma Y, Liang F, Zhang Y, Yu X, Li Z, An Q, Lv H, Wang J (2020) Non-contact vital signs monitoring of dog and cat using a UWB radar. Animals, 10: 205. https://doi: 10.3390/ani10020205
White J, Stickney A, Norris JM (2011) Feline immunodeficiency virus: Disease association versus causation in domestic and nondomestic felids. Vet Clin Small Anim 41: 1197–1208.