A meta-analysis of the association between Growth Hormone (GH) gene polymorphism and growth traits in cattle breeds

Published: Nov 9, 2022
Updated: 2022-11-09
2022-11-09 (3)
GH Birth weight Average daily gain Cattle Meta-analysis
M Bayraktar
M Özdemir

GH gene is one of the important genes that affect the productive and physiological traits in livestock. This study aimed to use a meta-analysis to determine the association of the GH gene with growth traits in cattle. Four different genetic models were used: dominant LL + LV versus VV, recessive LL versus LV + VV, complete over dominant LL+VV vs. LV and co-dominant LL vs. LV, LL vs. VV and LV vs. VV. The random-effect model was used in data analysis based on I2. Meta-analysis showed an effect of GH genotypes on the birth weight (BW) under the recessive (p<0.05) and complete over dominant (p<0.01) models. However, no association (p>0.05) was found under the dominant model. In terms of co-dominant model, the GH polymorphism showed a significant association with BW (SMD = 0.359, 95% CI = 0.119 to 0.599, p = 0.003) under LL vs. LV genotype combination patterns. No association was found between GH polymorphism and BW under LL vs. VV genotype combination. The results showed that the LL genotype had a significant effect on BW traits from LV and VV genotypes when comparing the models. The results showed an effect of the GH on ADG under four genetic models (p<0.05).

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Fedota O, Puzik N, Ruban S Y, Kolisnyk A (2018) Effect of cow genotype
by SNPS L127V/GH, F279Y, A257G/GHR and birth date on
calf growth performance of Aberdeen-Angus. Journal for veterinary
medicine, biotechnology and biosafety 4:29-36.
Pal A, Chakravarty A, Bhattacharya T, Joshi B, Sharma A (2004) Detection
of polymorphism of growth hormone gene for the analysis of relationship
between allele type and growth traits in Karan Fries cattle.
Asian-australasian journal of animal sciences 17:1334-37.
Sedykh Т, Dolmatova I, Valitov F, Gizatullin R, Kalashnikova L (2020)
The Influence of Growth Hormone Gene Polymorphism on Growth
Rate of Young Cattle. Iranian Journal of Applied Animal Science
Tatsuda K, Oka A, Iwamoto E, Kuroda Y, Takeshita H, Kataoka H, Kouno
S (2008) Relationship of the bovine growth hormone gene to carcass
traits in Japanese black cattle. Journal of animal breeding and genetics
Mohammadabadi M, Bordbar F, Jensen J, Du M, Guo W (2021) Key
Genes Regulating Skeletal Muscle Development and Growth in Farm
Animals. Animals 11:1-25.
Aytekin İ, Bayraktar M, Sakar Ç M, Ünal İ (2020) Association between
MYLK4 gene polymorphism and growth traits at different age stages
in Anatolian black cattle. Animal Biotechnology 31:555-60.
Fadhil M, Zülkadir U (2017) Molecular characterization of MSTN gene in
Holstein Friesians and Brown Swiss cattle breeds. Selcuk Journal of
Agriculture and Food Sciences 31:151-53.
Fadhil M, Zülkadir U (2021) Association between polymorphisms of
Myf5, MSTN and CAST genes and fattening performance in Brown
Swiss and Holstein cattle breeds. Animal Biotechnology 32:121-29.
Abousoliman I, Reyer H, Oster M, Muráni E, Mourad M, Abdel-Salam
Rashed M, Mohamed I, Wimmers K (2020) Analysis of candidate
genes for growth and milk performance traits in the Egyptian Barki
sheep. Animals 10:197.
Bayraktar M, Shoshin O (2021) Association between CAST and MSTN
gene polymorphisms with growth traits in Awassi sheep. Kuwait
Journal of Science
Eghbalsaied S, Akasheh L, Honarvar M, Forouzandeh A D, Ghazikhani-
Shad A, Bankizadeh F, Abdullahpour R (2016) Fine-tuning of season
definition for genetic analysis of fertility, productivity, and longevity
traits in Iranian Holstein dairy cows. Kuwait Journal of Science 43:
Gebreselassie G, Berihulay H, Jiang L, Ma Y (2019) Review on genomic
regions and candidate genes associated with economically important
production and reproduction traits in sheep (Ovies aries). Animals
Ishida T, Umebayashi A, Tsuruta S, Akashi R, Harada H (2010) Polymorphisms
in growth hormone gene and their associations with calf
weight in Japanese Black cattle. Animal science journal 81:623-29.
Lee J-H, Lee Y-M, Lee J-Y, Oh D-Y, Jeong D-J, Kim J-J (2013) Identification
of single nucleotide polymorphisms (SNPs) of the bovine growth
hormone (bGH) gene associated with growth and carcass traits in
Hanwoo. Asian-Australasian journal of animal sciences 26:1359-64
Paputungan U, Hakim L, Ciptadi G, Lapian H F (2016) Evaluation of
growth hormone genotypes associated with live weight of progeny
generation (G) derived from parental generation (G 0) of Indonesian
grade cattle. Livestock Research for Rural Development 28:1-9.
Møller N, Jørgensen J O L (2009) Effects of growth hormone on glucose,
lipid, and protein metabolism in human subjects. Endocrine reviews
Curi R A, Palmieri D A, Suguisawa L, Oliveira H N d, Silveira A C, Lopes
C R (2006) Growth and carcass traits associated with GH1/Alu I and
POU1F1/Hinf I gene polymorphisms in Zebu and crossbred beef cattle.
Genetics and Molecular Biology 29:56-61.
Dario C, Carnicella D, Bufano G (2005) A note on the growth hormone
(GH1-AluI) polymorphism in Podolian cattle in Southern Italy. Animal
Science Papers and Reports 23:43-49.
Grochowska R, Lunden A, Zwierzchowski L, Snochowski M, Oprządek J
(2001) Association between gene polymorphism of growth hormone
and carcass traits in dairy bulls. Animal Science 72:441-47.
Pereira A P, Alencar M M d, Oliveira H N d, Regitano L C d A (2005)
Association of GH and IGF-1 polymorphisms with growth traits in a
synthetic beef cattle breed. Genetics and Molecular Biology 28:230-
Sönmez Z, Özdemir M, Bayram B, Aksakal V (2018) Holstein ineklerde
GH/AluI polimorfizmi ile bazı süt verim özellikleri arasındaki ilişkiler.
Turkish Journal of Agriculture Food Science and Technology
Amiri S, Jemmali B, Ferchichi M A, Jeljeli H, Boulbaba R, Ben Gara A
(2018) Assessment of growth hormone gene polymorphism effects on
reproductive traits in Holstein dairy cattle in Tunisia. Archives Animal
Breeding 61:481-89.
Bordonaro S, Tumino S, Marletta D, De Angelis A, Di Paola F, Avondo M,
Valenti B (2020) Effect of GH p. L127V polymorphism and feeding
systems on milk production traits and fatty acid composition in Modicana
cows. Animals 10:1651.
Hradecka E, Citek J, Panicke L, Rehout V, Hanusova L (2008) The relation
of GH1, GHR and DGAT1 polymorphisms with estimated breeding
values for milk production traits of German Holstein sires. Czech Journal of Animal Science 53:238.
Schlee P, Graml R, Rottmann O, Pirchner F (1994) Influence of growthhormone
genotypes on breeding values of Simmental bulls. Journal
of animal Breeding and Genetics 111:253-56.
Akçay A, Akyüz B, Bayram D (2015) Determination of the AluI polymorphism
effect of bovine growth hormone gene on carcass traits in Zavot
cattle with analysis of covariance. Turkish Journal of Veterinary
and Animal Sciences 39:16-22.
Silveira L G G, Furlan L R, Curi R A, Ferraz A L J, Alencar M M d, Regitano
L C, Martins C L, Arrigoni M d B, Suguisawa L, Silveira A C
(2008) Growth hormone 1 gene (GH1) polymorphisms as possible
markers of the production potential of beef cattle using the Brazilian
Canchim breed as a model. Genetics and Molecular Biology 31:874-
Sari E, Noor R, Sumantri C, Yunus M, Han J (2013) Identification of Single
Nucleotide Polymorphism on Growth Hormone Gene in Aceh
Cattle. Media Peternakan 36:21-21.
Ünal E Ö, Işık R, Soysal M İ (2020) Identification of novel single nucleotide
polymorphisms in the growth hormone (GH) gene in Anatolian
water buffalo (Bubalus bubalis) populations in Turkey. Revista Brasileira
de Zootecnia 49:
Çinar M U, Akyüz B, Kiyici J M, Arslan K, Kaliber M, Aksel E G (2018)
Effects of GH-AluI and MYF5-TaqI polymorphisms on weaning
weight and body measurements in Holstein young bulls. Kafkas
Üniversitesi Veteriner Fakültesi Dergisi 24:873-80.
Hartatik T, Fathoni A, Bintara S, Widyobroto B, Agus A, Budisatria I,
Leroy P (2020) The genotype of growth hormone gene that affects
the birth weight and average daily gain in crossbred beef cattle. Biodiversitas
Pal A, Chakravarty A (2020) Mutations in growth hormone gene affect
stability of protein structure leading to reduced growth, reproduction,
and milk production in crossbred cattle-an insight. Domestic animal
endocrinology 71:1-14.
Reis C, Navas D, Pereira M, Cravador A (2001) Growth hormone alui
polymorphism analysis in eight portuguese bovine breeds. Archivos
de zootecnia 50:41-48.
Thomas M, Enns R, Shirley K, Garcia M, Garrett A, Silver G (2007) Associations
of DNA polymorphisms in growth hormone and its transcriptional
regulators with growth and carcass traits in two populations of
Brangus bulls. Genetics and Molecular Research 6:222-37.
Arnim, Yurnalis, Tinda A, Dino E P (2018) Association of GH, IGF1R,
and PIT1 genes polymorphism with average daily gain and body
measurement in Pesisir cattle. Nusantara Bioscience 10:221-25.
Di Stasio L, Sartore S, Albera A (2002) Lack of association of GH1 and
POU1F1 gene variants with meat production traits in Piemontese cattle.
Animal Genetics 33:61-64.
Hartatik T, Volkandari S, Sumadi. Proceedings of the 15th AAAP Animal
Science Congress, Thailand, 2012: 881-84.
Soewandi B D P, Hartati, Hapsari A A R. The 7th International Conference
on Sustainable Agriculture and Environment, Indonesia, 2021, 637:
-9. IOP Publishing.
Lee Y H (2015) Meta-analysis of genetic association studies. Annals of
laboratory medicine 35:283-87.
Mahmoudi P, Rashidi A, Rostamzadeh J, Razmkabir M (2019) Association
between c. 1189G> A single nucleotide polymorphism of GDF9
gene and litter size in goats: A meta-analysis. Animal reproduction
science 209:106140.
Mahmoudi P, Rostamzadeh J, Rashidi A, Zergani E, Razmkabir M (2020)
A meta‐analysis on association between CSN3 gene variants and milk
yield and composition in cattle. Animal genetics 51:369-81.
Bangar Y C, Magotra A (2021) Meta-analysis of SNP in growth hormone
gene associated with milk traits in dairy cows. Tropical animal health
and production 53:1-7.
Bangar Y C, Magotra A, Patil C, Jindal N (2021a) Meta-analysis of Genetic
Structure and Association of Prolactin Gene with Performance
Traits in Dairy Cattle in India. Biochemical Genetics 59:668-77.
Özdemir M, Kopuzlu S, Topal M, Bilgin O C (2018) Relationships between
milk protein polymorphisms and production traits in cattle:
a systematic review and meta-analysis. Archives Animal Breeding
Bangar Y C, Magotra A, Chauhan A, Yadav A (2021b) Genetic polymorphisms
of kappa casein gene and its association with milk and
composition traits in cows: An updated meta-analysis. Meta Gene
Chong Y, Liu G, Jiang X (2019) Effect of BMPRIB gene on litter size
of sheep in China: A meta-analysis. Animal reproduction science
Özdemir M, Esenbuğa N (2020) Associations among beta-lactoglobulin
genotypes and some production traits in sheep: A systematic review
and meta-analysis. Journal of Animal and Plant Sciences 30:1092-97.
Fedota O, Ruban S, Lysenko N, Kolisnyk A, Goraichuk I, Tyzhnenko
T (2016) SNP L127V of growth hormone gene in breeding herd of
Aberdeen Angus in Kharkiv region. Journal for Veterinary Medicine,
Biotechnology and Biosafety 2:5-11.
Kayumov F, Gerasimov N, Emel’yanenko A, Tret’yakova R, Sangadzhiev
R, Alimova S. 2019. The association of polymorphic variants of
growth hormone gene with slaughter traits and carcass composition
in crossbred Red Angus × Kalmyk bull-calves. Presented at Earth and
Environmental Science, Russia
Biswas T, Bhattacharya T, Narayan A, Badola S, Kumar P, Sharma A
(2003) Growth Hormone Gene Polymorphism and Its Effect on Birth
Weight in Cattle and Buffalo Asian-australasian journal of animal sciences
Plakhtukova V, Selionova M, Gladkikh M Y, Kuznetsova O. E3S Web of
Conferences2020, 224: 1-9.
Ruban S, Fedota A, Lysenko N, Kolisnyk A, Goraichuk I. Zootechnycal
science - an important factor for the european type of the agriculture,
Maximovca, 2016: 264-68.
Selionova M, Plakhtyukova V. 2020. Polymorphism of the CAPN1 and
GH genes and its relationship with the productivity of cattle of the
Kazakh white-headed breed. Presented at Earth and Environmental
Science, Russian Federation
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