Investigation of Serum allergen-specific IgE concentrations in feline asthma: a clinical experience

PDF
Published: Jul 6, 2023
Versions:
2023-07-06 (1)
DOI: https://doi.org/10.12681/jhvms.30377
Keywords:
allergy cat feline asthma HDMAs IgE
N Keskin Yılmaz
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey
https://orcid.org/0000-0002-6287-1157
D Kahraman
Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey; 2Arbor Vitae Veterinary Clinic, Ankara, Turkey
H Albasan
Pet Depot Veterinary Group, La Verne, LA, CA, USA
Abstract

The aim of this study is to investigate allergen agents by allergen-specific serum IgE analysis in domestic cats diagnosed with feline asthma (FA). A total of 21 cats (16 FA and 5 control cats) were included in the study. Allergen-specific serum IgE levels were measured in cats diagnosed with feline asthma and in the control group. Allergen levels were classified as negative, weak, moderate and strong. The difference between the two groups was compared statistically. While the mean age of the cats in the FA group was 3.9kg ±2.4 years, the mean age of the cats in the control group was 3.4±2.2 years. The most common clinical manifestations in cats with FA were cough, sneezing, wheezing, and acute dyspnea, respectively. Allergen-specific IgE levels tested for 20 different allergens showed that 14 out of 16 cats developed a reaction to more than one allergen. The vast majority of cats with FA had a moderate or strong positive reaction to house dust mites. In conclusion, FA is an important and common chronic lower respiratory tract disease of feline patients and allergen-specific serum IgE levels can be easily used in clinical practice to guide the selection of allergens in the treatment of this disease and adjust for the quality of life and well-being of cats.

Article Details
  • Section
  • Research Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
References
Adamama-Moraitou KK, Patsikas MN, Koutinas AF (2004). Feline lower
airway disease: a retrospective study of 22 naturally occurring cases
from Greece. J Feline Med Surg 227-33. https://doi.org/10.1016/j.
jfms.2003.09.004
Cao H, Liu Z (2020). Clinical significance of dust mite allergens. Mol Biol
Rep 47(8):6239-46. https://doi.org/10.1007/s11033-020-05613-1
Carolino N, Duarte S (2020). Determinant and conditioning factors of
feline asthma: a questionnaire-base study. J. Hell. Vet. Med, 71(4),
-2568.
Chalifoux NV, Drobatz KJ, Reineke EL (2021). Predictors of inflammatory lower airway disease in cats presented to the emergency room
in respiratory distress: a case-control study. J Feline Med Surg
(12):1098-108. https://doi.org/10.1177/1098612X21996145
Chang, C. H., Lee-Fowler, T. M., DeClue, A. E., Cohn, L. A., Robinson,
K. L., & Reinero, C. R. (2011). The impact of oral versus inhaled glucocorticoids on allergen specific IgE testing in experimentally asthmatic cats. Vet. Immunol. Immunopathol., 144(3-4), 437-441.
Gøtzsche PC, Johansen HK (2008). House dust mite control measures
for asthma: systematic review. Allergy 63(6):646-59. https://doi.
org/10.1111/j.1398-9995.2008.01690.x
Grotheer M, Hirschberger J, Hartmann K, Castelletti N, Schulz B (2020).
Comparison of signalment, clinical, laboratory and radiographic parameters in cats with feline asthma and chronic bronchitis. J Feline
Med Surg 22(7):649-55. https://doi.org/10.1177/1098612X19872428
Johnson LR, Drazenovich TL (2007). Flexible bronchoscopy and bronchoalveolar lavage in 68 cats: (2001–2006). J Vet Intern Med 21:219–
https://doi.org/10.1892/0891 -6640(2007)21[219:fbabli]2.0.co;2
Loft KE, Rosser Jr EJ (2010). Group 1 and 2 Dermatophagoides house
dust mite allergens in the microenvironment of cats. Vet Dermatol
(2):152-8. https://doi.org/10.1111/j.1365-3164.2009.00771.x
Lopez A, Martinson SA (2017). Respiratory system, mediastinum, and
pleurae. Pathologic basis of veterinary disease, 471.
National Center for Health Statistics (2020). Interactive Summary Health
Statistics for Adults. [Cited 2022 April 5]. Available from: https://
wwwn.cdc.gov/NHISDataQueryTool/SHS_adult/index.html
Niimi A (2011). Cough and asthma. Curr Respir Med Rev 1;7(1):47-54.
https://doi.org/10.2174/157339811794109327
Norris CR, Byerly JR, Decile KC, Berghaus RD, Walby WF, Schelegle
ES, Hyde DM, Gershwin LJ (2003). Allergen-specific IgG and IgA
in serum and bronchoalveolar lavage fluid in a model of experimental feline asthma. Vet Immunol Immunopathol 15;96(3-4):119-27.
https://doi.org/10.1016/S0165-2427(03)00144-2
Padrid P (2000). Feline asthma: diagnosis and treatment. Veterinary Clinics: Small Animal Practice. 2000 Nov 1;30(6):1279-93.
Reinero CR, DeClue AE, Rabinowitz P. Asthma in humans and cats: is
there a common sensitivity to aeroallegens in shared environments?
Environmental research. 2009 Jul 1;109(5):634-40. https://doi.
org/10.1016/j.envres.2009.02.001
Padrid P (2000). Feline asthma: diagnosis and treatment. Vet Clin North
Am Small Anim Pract 1;30(6):1279-93.
Reinero CR, DeClue AE (2010). Feline tracheobronchial disease. In BSAVA manual of canine and feline cardiorespiratory medicine pp. 280-
, BSAVA Library.
Reinero CR (2011). Advances in the understanding of pathogenesis,
and diagnostics and therapeutics for feline -allergic asthma. Vet J
;190(1):28-33. https://doi.org/10.1016/j.tvjl.2010.09.022
Reinero CR. Feline asthma (2014). In: Noli C, Foster A, Rosenkrantz
W,eds.Veterinary Allergy, 1st edn. West Sussex, UK: John Wiley
&Sons Ltd, pp: 239–245.
Sigrist NE, Adamik KN, Doherr MG, Spreng DE (2011). Evaluation of
respiratory parameters at presentation as clinical indicators of the respiratory localization in dogs and cats with respiratory distress. JVECC
(1):13-23. https://doi.org/10.1111/j.1476-4431.2010.00589.x
Trzil JE, Reinero CR (2014). Update on feline asthma.Vet Clin North
AmSmall Anim Pract 44: 91–105. https://doi.org/10.1016/j.
cvsm.2013.08.006
Trzil JE (2020). Feline Asthma: Diagnostic and Treatment Update.
Vet Clin North AmSmall Anim Pract 1;50(2):375-91. https://doi.
org/10.1016/j.cvsm.2019.10.002
Ural K, Erdoğan H, Gültekin M (2018). Allergen specific IgE determination by in vitro allergy test in head and facial feline dermatitis:
A pilot study. Ankara Üniv Vet Fak Derg 65, 379-386. https://doi.
org/10.1501/Vetfak_0000002871
Venema C, Patterson C, Venema CM (2010). Feline asthma: what’s new
and where might clinical practice be heading?.J Feline Med Surg
(9):681-92. https://doi.org/10.1016/j.jfms.2010.07.012
Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, Abbasi-Kangevari M, Abbastabar H, Abd-Allah F, Abdelalim A, Abdollahi
M (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global
Burden of Disease Study 2019. The Lancet 17;396(10258):1204-22.
https://doi.org/10.1016/S0140-6736(20)30925-9
Ybarra WL, Johnson LR, Drazenovich TL, Johnson EG, Vernau W
(2012). Interpretation of multisegment bronchoalveolar lavage in cats
(1/2001–1/2011). JVIM 26(6):1281-7. https://doi.org/10.1111/j.1939- 1676.2012.01016.x