Iatrogenic magnesium overdose in a golden retriever - case study

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Published: May 20, 2026
DOI: https://doi.org/10.12681/jhvms.40028
Keywords:
hypermagnesemia dog bradycardia atropine
D Țogoe
1University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, Bucharest, Romania
https://orcid.org/0009-0004-8291-8903
NA Minca
1University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, Bucharest, Romania
A Ștefănescu
1University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, Bucharest, Romania
https://orcid.org/0009-0004-7869-3094
AB Vițălaru
1University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, Bucharest, Romania
https://orcid.org/0000-0002-9209-3114
Abstract

This case study describes the clinical presentation, diagnosis, evolution and treatment of a 1-year-old golden retriever dog who accidentally ingested 100 tablets of magnesium-based dietary supplement. 48 hours after ingestion, he showed clinical signs associated with digestive disorders and cardio-vascular impairment such as vomiting, hypotension, decreased heart rate and the appearance of cardiac compensatory phenomena that are prior to cardiac arrest. The report highlights the therapeutic approach and clinical management strategies, as well as the results of the treatment applied. Hypermagnesemia has been reported rarely, so the protocol applied was focused on stabilization and careful cardiovascular, renal and endocrine monitoring.


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References
Bonagura JD, Gelzer AR (2018) Textbook of Veterinary Internal Medicine.
th ed. Elsevier.
Bruyette D (2020) Clinical Small Animal Internal Medicine.
Cortes Y, Moses L (2007) Magnesium disturbances in critically ill patients.
Emerg Med 29(7).
de Baaij JHF, Hoenderop JGJ, Bindels RJM (2015) Magnesium in man:
Implications for health and disease. Physiol Rev 95(1):1–46. https://
doi.org/10.1152/physrev.00012.2014
Goggs R, De Rosa S, Fletcher DJ (2017) Electrolyte disturbances are
associated with non-survival in dogs – A multivariable analysis.
Front Vet Sci 4:135. doi: 10.3389/fvets.2017.00135.
Haase M, et al. (2013) Cardiovascular–renal axis disorders in the domestic
dog and cat. Vet J 196(3):292–297.
Humphrey S, Kirby R, Rudloff E (2015) Magnesium physiology and
clinical therapy in veterinary critical care. J Vet Emerg Crit Care
(2):210–225.
Kittleson MD, Kienle RD (1998) Small Animal Cardiovascular Medicine.
Mosby.
Merck Veterinary Manual (n.d.) Heart failure in dogs and cats. https://
www.merckvetmanual.com/circulatory-system/heart-failure-indogs-
and-cats/heart-failure-in-dogs-and-cats. Accessed April 20,
Mochizuki M, Akagi K, Inoue K, Shimamura K (1998) A single dose
toxicity study of magnesium sulfate in rats and dogs. J Toxicol Sci
(Suppl 1):31–35. doi: 10.2131/jts.23.supplementi_31.
Mouton A, Celliers A, Thompson PN, Mellanby RJ, Schoeman JP
(2025) Calcium and magnesium abnormalities in puppies with
parvoviral enteritis. Am J Vet Res 86(1):ajvr.24.07.0187. https://
doi.org/10.2460/ajvr.24.07.0187
REFERENCES
Oyama MA, Sisson DD (2011) Electrocardiography and arrhythmia
diagnosis in dogs and cats. In: Tilley LP, Smith FWK (eds) Manual
of Canine and Feline Cardiology. 4th ed, Elsevier, pp 125–158.
Riegger GA, et al. (1984) Role of the renin-angiotensin system in the
development of congestive heart failure in the dog as assessed by
chronic converting-enzyme blockade. Am J Cardiol 53(4):614–618.
Romani AMP (2013) Magnesium in health and disease. In: Vink R,
Nechifor M (eds) Magnesium in the Central Nervous System. University
of Adelaide Press, pp 113–125.
Silverstein DC (2022) Small Animal Critical Care Medicine. 3rd ed.
Tilley LP, Smith FWK (2015) Blackwell’s Five-Minute Veterinary Consult:
Canine and Feline. Wiley-Blackwell.
Touyz RM (2004) Role of magnesium in the pathogenesis of hypertension.
Mol Aspects Med 24(1–3):107–136. https://doi.org/10.1016/j.
mam.2003.10.007
VMD C, DACVECC Kenneth (2004) Iatrogenic magnesium overdose: 2
case reports. J Vet Emerg Crit Care 14:115–123. doi: 10.1111/j.1534-
2004.00103.x.
Vos MA, et al. (1998) The canine chronic atrioventricular block model
in cardiovascular research: A review. Cardiovasc Res 39(1):59–70.
Ware WA (2016) Cardiovascular Disease in Small Animal Medicine.
Manson Publishing.
Willis R, Oliveira P, Mavropoulou A (2018) Guide to Canine and Feline
Electrocardiography. Wiley. ISBN-10: 1119253845.
Ynaraja Ramírez E (2022) Blood Pressure in Cats and Dogs: A Clinical
Manual. Grupo Asís Biomedia.