Assessment of serum protein profile in sickle cell disease
Abstract
Background: Sickle Cell disease (SCD) is known to be caused by a mutation in the beta-globin gene of the hemoglobin that affects the red blood cells (RBCs) and is passed down through generations. This study was carried out to determine the effect of sickling of RBC on serum protein profile in SCD individuals.
Methods: A case-controlled study was carried out among 80 patients. They were forty-five sickle cell disease individuals (HbSS) attending Children Specialist Hospital Ilorin and thirty-five healthy controls (HbAA). The levels of total protein and albumin were determined spectrophotometrically and serum protein electrophoresis (SPE) was carried out using cellulose acetate electrophoresis.
Results: Significant hypoalbuminemia and hypergammaglobulinemia were observed in SCD groups compared with controls. A higher proportion of the SCD group, 11(25%) had hypergammaglobulinemia and 21(49%) had hypoalbuminemia (P<0.05). Plasma protein electrophoresis in SCD patients shows an intense colour at the gamma region which was not seen in control. There was a significant relationship between the patterns of serum protein electrophoresis and the frequency of crisis.
Conclusions: Sickle cell disease crisis and other associated underlying conditions may be prevented early through assessment of serum protein profile, especially SPE. Hypergammaglobulinemia and hypoalbuminemia may be associated with frequent episode of crisis.
Article Details
- How to Cite
-
Ibrahim, M., Yakub, H. A., Garuba, W. O., Ogunniyi, T., Lawal, A. Z., Adunmo, G. O., Ogunwale, K. A., Busari, A. O., Popoola, A. N., Eleha, S. I., Nuhu, A., & Ibrahim, M. (2024). Assessment of serum protein profile in sickle cell disease. Health & Research Journal, 10(4), 245–254. https://doi.org/10.12681/healthresj.36006
- Section
- Original Articles
Copyright notice:
Authors retain copyright of their work and grant the Health and Research Journal the right of first publication.
License:
Articles are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license permits use, sharing, adaptation, distribution, and reproduction in any medium or format, including for commercial purposes, provided that appropriate credit is given to the author(s) and the original publication in this journal, a link to the license is provided, and any changes are indicated.
Attribution requirement:
Any reuse must include the article citation and DOI (where available), and indicate if changes were made.
