CRISPR/Cas9: Η νέα τεχνολογία τροποποίησης του γονιδιώματος που άνοιξε τον ασκό του Αιόλου (;)

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Pubblicato: Νοε 22, 2015
DOI: https://doi.org/10.12681/bioeth.19626
Βασιλική Μολλάκη (Vassiliki Mollaki)
Hellenic National Bioethics Commission, Athens, Greece
https://orcid.org/0000-0002-8479-8704
Abstract
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Riferimenti bibliografici
Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X, Chen Y, Li Y, Sun Y, Bai Y, Songyang Z, Ma W, Zhou C, Huang J. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell. 2015 May;6(5):363-72.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science. 2014 Mar 14;343(6176):1247997.
Kim YG, Cha J, Chandrasegaran S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci U S A 1996;93:1156–60.
Christian M, Cermak T, Doyle EL, Schmidt C, Zhang F, Hummel A, Bogdanove AJ, Voytas DF. Targeting DNA double-strand breaks with TALeffector nucleases. Genetics. 2010 Oct;186(2):757-61.
Statement on NIH funding of research using gene-editing technologies in human embryos. April 29, 2015. http://www.nih.gov/about/director/04292015_statement_gene_editing_technologies.htm.
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 3;348(6230):36-8.
The ISSCR Statement on Human Germline Genome Modification. 19 March, 2015 http://www.isscr.org/home/about-us/news-press-releases/2015/2015/03/19/statement-on-human-germline-genome-modification.
US science academies take on human-genome editing. 18 May 2015. Nature. http://www.nature.com/news/us-science-academies-take-on-human-genome-editing-1.17581.