Praziquantel depletion from muscle plus skin tissue of gilthead sea bream (Sparus aurata)


DIMITRA KOGIANNOU
https://orcid.org/0000-0001-5503-3828
GEORGE RIGOS
https://orcid.org/0000-0002-3148-6213
Resumen

This study determined the depletion pattern of praziquantel (PZQ) from gilthead sea bream (Sparus aurata) muscle plus skin tissue. Fish averaging 100.2 ± 17.7 g and kept at 25oC received a PZQ-dosing of 150 mg/kg fish for 3 days. Muscle plus skin tissue of ten fish were sampled on days 1, 2, 3, 4, and 6 days post-treatment. Depletion of PZQ from edible gilthead sea bream tissues was rapid, as PZQ concentrations decreased to 0.04 μg/g as early as 24 h post-treatment, while it was undetectable at 72 h. This information confirms the fact that PZQ is depleted fast from farmed animals, including fish such as the gilthead sea bream, and its levels in edible tissues fell below the detection limit in approximately 75 dd.

Article Details
  • Sección
  • Short Communication
Descargas
Los datos de descargas todavía no están disponibles.
Citas
Andrews, P., Thomas, H., Pohlke, R., Seubert, J., 1983. Praziquantel. Medicinal Research Reviews, 3 (2), 147-200.
Bader, C., Starling, D.E., Jones, D.E., Brewer, M.T., 2019. Use of praziquantel to control platyhelminth parasites of fish. Journal of Veterinary Pharmacology and Therapeutics, 42 (2), 139-153.
Baralla, E., Varoni, M.V., Nieddu, M., Demontis, M.P., Merella, P. et al., 2020. Determination of Praziquantel in Sparus aurata L. After Administration of Medicated Animal Feed. Animals, 10 (3), 528.
Björklund, H., Bylund, G., 1987. Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.). Parasitology Research, 73 (3), 240-244.
EMEA, 1988. The European Agency for the Evaluation of Medicinal Products. Veterinary Medicines Evaluation Unit.
EMEA/MRL/523/98-FINAL. Committee for Veterinary Medicinal Products. Praziquantel. Report 2.
Eom, K., Kim, S., Rim, H.J., 1988. Efficacy of praziquantel (Cesocide® injection) in treatment of cestode infections in domestic and laboratory animals. The Korean Journal of Parasitology, 26 (2), 121-126.
Hirazawa, N., Mitsuboshi, T., Hirata, T., Shirasu, K., 2004. Susceptibility of spotted halibut Verasper variegatus (Pleuronectidae) to infection by the monogenean Neobenedenia girellae (Capsalidae) and oral therapy trials using praziquantel. Aquaculture, 238 (1-4), 83-95.
Hormazábal, V., Yndestad. M., 1995. High-performance liquid chromatographic determination of praziquantel in plasma and tissues of cultured fish for residue and pharmacokinetic studies. Journal of Liquid Chromatography, 18 (3), 589-597.
Ishimaru, K., Mine, R., Shirakashi, S., Kaneko, E., Kubono, K. et al., 2013. Praziquantel treatment against Cardicola blood flukes: Determination of the minimal effective dose and pharmacokinetics in juvenile Pacific bluefin tuna. Aquaculture, 402, 24-27.
Kim, C.S., Cho, J.B., Ahn, K.J., Lee, J.I., Kim, K.H., 2003. Depletion of praziquantel in muscle tissue and skin of cultured rockfish (Sebastes schlegeli) under the commercial culture conditions. Aquaculture, 219 (1-4), 1-7.
Kim, K., Kim, C., Kim, J.H., 2001. Depletion of praziquantel in plasma and muscle tissue of cultured rockfish Sebastes schlegeli after oral and bath treatment. Diseases of Aquatic Organisms, 45 (3), 203-207.
Rogstad, A., Hormazábal, V., Yndestad, M., 1987. Extraction of praziquantel from fish tissue and its determination by high-performance liquid chromatography. Journal of Chromatography, 391 (1), 328-333.
Sharp, N.J., Diggles, B.K., Poortenaar, C.W., Willis, T.J., 2004. Efficacy of Aqui-S, formalin and praziquantel against the monogeneans, Benedenia seriolae and Zeuxapta seriolae, infecting yellowtail kingfish Seriola lalandi lalandi in New Zealand. Aquaculture, 236 (1-4), 67-83.
Sitjà-Bobadilla, A., Redondo, M.J., Alvarez-Pellitero, P., 2010. Occurrence of Sparicotyle chrysophrii (Monogenea: Polyopisthocotylea) in gilthead sea bream (Sparus aurata L.) from different mariculture systems in Spain. Aquaculture Research, 41 (6), 939-944.
Soukupova-Markova, Z., Doubkova, V., Marsalek, P., Svobodova, Z., Papežíková, I. et al., 2016. Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration. Neuro Endocrinology Letters, 36 (Suppl 1) 64-70.
Staudt, U., Schmahl, G., Blaschke, G., Mehlhorn, H., 1992. Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro. Parasitology Research, 78, 392-397.
Tubbs, L., Mathieson, T., Tingle, M., 2008. Metabolism of praziquantel in kingfish Seriola lalandi. Diseases of Aquatic Organisms, 78 (3), 225-233.
Tubbs, L.A., Tingle, M.D., 2006. Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi. Aquaculture, 261 (4), 1168-1174.
Xu, N., Dong, J., Yang, Y., Ai, X., 2016. Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus. Diseases of Aquatic Organisms, 119 (1), 67-74.
Artículos más leídos del mismo autor/a