Swine model in cardiopulmonary resuscitation research

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Published: Nov 20, 2017
DOI: https://doi.org/10.12681/jhvms.14935
Keywords:
cardiac arrest experimental models swine coronary perfusion pressure
Th. XANTHOS (Θ. ΞΑΝΘΟΣ)
University of Athens, Medical School, Department of Experimental Surgery and Surgical Research
Abstract

Cardiac Arrest (CA) constitutes a real medical emergency. Various experimental models have been developed in order to test experimental treatments. Animal models that have been used in CA research are rodents, rabbits, cats and dogs, primates and swine. Among these, swine are used more often. The reason behind this choice is mostly its close resemblance to the human cardiac anatomy and physiology. Various haemodynamic variables have been investigated as predictors of the return of spontaneous circulation (ROSC). Coronary Perfusion Pressure (CPP) is the only proven predictor for ROSC. CPP, which is responsible for myocardial perfusion, greatly augments during chest compressions. ROSC and therefore survival after CA has been associated with CCP values greater than 15 mmHg for humans and 25 mmHg for animals. For the experimental induction of CA various electric sources have been used. All these experimental devices could be potentially dangerous for researchers, even though, no incidence of electrocution has been reported in the international literature. The ordinary cadmium battery appears to be safer and is an extremely effective way of inducing cardiac arrest.

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References
Anonymous (2000) The American Heart Association in Collaboration with the International Liaison Committee Resuscitation (ILCOR). Resuscitation and Emergency Cardiovascular Care an International consensus on Science. Resuscitation 46:135-162.
Bassiakou E, Xanthos T, Koudouna E, Goulas S, Prapa V, Papadimitriou D, Rokas G, Papadimitriou L (2008) Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation. Am J Emerg Med, 26:578-584.
Bulger RE (1987) Use of animals in experimental research: A scientist's perspective. Anat Ree, 219:215-220.
Dontas I (1994). Η επιλογή του καταλληλότερου πειραματόζωου ως πειραματικό πρότυπο. Ελληνική Χειρουργική, 66:28-31.
Hughes HC (1986) Swine in cardiovascular research. Lab Anim Sci, 36:348-350.
Hubert MB, Salazkin I, Desjardins J, Blaise G (2003) Cardiopulmonary bypass surgery in swine: a research model. J Exp Anim Sci, 42:135-149.
Kloeck W, Cummins R, Chamberlain D, Bossaert L, Callan V, Carli Ρ, Christenson J, Connolly B, Ornato J, Sanders A, Steen Ρ (1997) An advisory statement by the Advanced Life Support Working Group of the International Liaison Committee on Resuscitation. Resuscitation 34:109-111.
Kofier J., Hattori K, Sawada M, DeVries AC, Martin LJ, Hum PD, Traystman RJ (2004) Histopathological and behavioural characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. J Neurosci Methods, 136:33-44.
Lelovas Ρ, Marinou Κ, Xanthos Τ, Papadimitriou D, Perrea D, Dontas I (2006) Swine as an animal model of cardiopulmonary resuscitation. Journal of the Hellenic Veterinary Medical Society, 57:27-41.
Papadimitriou L, Xanthos Τ (2006). Η έρευνα στην Καρδιοαναπνευστική Αναζωογόνηση. Στο: Καρδιοαναπνευστική Αναζωογόνηση, 1η έκδοση, Εκδόσεις Βήτα, Αθήνα, σελ 316-320.
Sans S, Kesteloot Η, Kromhout D (1997) The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J, 18:1231-1248.
Stroumpoulis K, Xanthos T, Rokas G, Kitsou V, Papadimitriou D, Serpetinis I, Perrea D, Papadimitriou L, Kouskouni E (2008) Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study. Crit Care, 12:R40.
Xanthos T, Lelovas P, Vlachos I, Tsirikos-Karapanos N, Kouskouni E, Perrea D, Dontas I (2007a) Cardiopulmonary arrest and resuscitation in Landrace/Large White swine: a research model.Lab Anim, 41:353-362.
Xanthos T, Tsirikos-Karapanos N, Papadimitriou D, Vlachos IS, TsiftsiK, Ekmektzoglou KA, Papadimitriou L (2007b) Resuscitation outcomes comparing year 2000 with year 2005 ALS guidelines in a pig model of cardiac arrest. Resuscitation, 73:459-466.
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