| More

Swine as an animal model of cardiopulmonary resuscitation

Views: 320 Downloads: 264
P. LELOVAS (Π. ΛΕΛΟΒΑΣ), K. MARINOU (Κ. ΜΑΡΙΝΟΥ), Th. XANTHOS (Θ. ΞΑΝΘΟΣ), D. PAPADIMITRIOU (Δ. ΠΑΠΑΔΗΜΗΤΡΙΟΥ), D. PERREA (Δ. ΠΕΡΡΕΑ), I. DONTAS (Ι. ΔΟΝΤΑ)
P. LELOVAS (Π. ΛΕΛΟΒΑΣ), K. MARINOU (Κ. ΜΑΡΙΝΟΥ), Th. XANTHOS (Θ. ΞΑΝΘΟΣ), D. PAPADIMITRIOU (Δ. ΠΑΠΑΔΗΜΗΤΡΙΟΥ), D. PERREA (Δ. ΠΕΡΡΕΑ), I. DONTAS (Ι. ΔΟΝΤΑ)

Abstract


This paper reviews the advantages of swine in relation to other animal models of cardiopulmonary resuscitation referred to in the literature. The causes of cardiac arrest and the difficulties raised during research in humans are presented. All animal models used in this particular field are discussed and a detailed review is performed regarding the major anatomical and physiological similarities between swine and man, as well as the experimental studies published in the international literature.


Keywords


animal models; swine; cardiopulmonary resuscitation

Full Text:

PDF

References


Anonymous (1981) Report of the Working Group on Arteriosclerosis of the National Heart, Lung and Blood Institute (Volume 2): Patient oriented Research Fundamental and Applied, Sudden Cardiac Death. Department of Health, Education and Welfare, NIH publication No. 82-2035, Washington DC, US Government Printing Office 114-122.

Anonymous (1997a) Advanced Life Support Working Group of the International Liaison Committee on Resuscitation.An advisory statement by the Advanced Life Support Working Group of the International Liaison Committee on Resuscitation. Resuscitation 34:113-115.

Anonymous. (1997β) Consensus statement of the Joint Steering Committees of the unexplained cardiac arrest registry Europe and of the idiopathic ventricular fibrillation registry of the United

States. Survivors of out-of hospital cardiac arrest with apparently normal heart: need for definition and standardize clinical evaluation. Circulation 95:265-272.

Anonymous (1998) The 1998 European Resuscitation Council Guidelines for Adult Advanced Life Support In: Bossaert L (ed). European Resuscitation Council guidelines for Resuscitation. Amsterdam: Elsevier: 36-47.

Anonymous (2000) The American Heart Association in Collaboration with the International Liaison Committee Resuscitation (ILCOR). Resuscitation and Emergency Cardiovascular Care an

International consensus on Science. Resuscitation 46: 135-162.

Anonymous (2001) Advanced Life Support Course Provider Manual 4th Edition: 1

Anonymous (2002) Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. Ν Eng J Med 346: 549-356.

Becker LB, Ostrander MP, Barret J, Kondos GT (1991) Outcome of CPR in a Large metropolitan area-where are the survivors? Ann Emerg Med 20:355-361.

Benson DM, O'Neil B, Kakish E, Erpelding J, Alousi S, Mason R, Piper D, Rafols J (2005) Open-chest CPR improves survival and neurologic outcome following cardiac arrest. Resuscitation 64:

-217.

Bharati S, Levine M, Huang SK, Handler B, Parr GV, Bauernfeind R, Lev M (1991) The conduction system of the swine heart. Chest 100: 207-212.

Bloor CM, White FC, Lammers RJ (1986) Cardiac ischemia and coronary blood flow in swine, In Stanton, HC and Mersmann HJ (eds), Swine in Cardiovascular Research, Vol 2 Boca Raton: CRC Press: 87-119.

Bloor CM, White FC, Roth DM (1992) The pig as a model of myocardial ischemia and gradual coronary occlusion. In Swindle MM (ed), Swine as models in biomedical research. Ames: Iowa

State University Press: 163-175.

Bottinger B, Teschendorf P, Krumniki JJ, Vogel Ρ, Galmbacher R, Schmitz Β, Motsch J, Martin E, Gass Ρ (1999) Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal

degeneration and early induction of transcription factor genes in the hippocampus. Mol Brain Res 65: 135-142.

Brown CG, Griffith RF, Neely D, Hobson J, Miller Β (1993) The effect of intravenous magnesium administration on aortic, right atrial and coronary perfusion pressures during CPR in swine. Resuscitation 26: 3-12.

Brownlee RR, Swindle MM, Bertolet R and Neff Ρ (1997) Toward a preshaped catheter and system parameters to achieve single lead DDP pacing. PACE 20 (Suppl 1): 1354-1358.

Brutel de la Riviere A, Quaegebeur JM, Hennis PJ, Brutel de la Riviere G, Van Herpen G (1983) Growth of an aorta-coronary anastomosis. An experimental study in pigs. J. Thorac. Cardiovasc. Surg 86: 393-399.

Bulger RE. (1987) Use of animals in experimental research: A scientist's perspective. Anat Record 219: 215-220.

Chambless L, Keil U, Dobson A, Mähoönen M, Kuulasmaa Κ, Rajakangas AM, Löwel H, Tunstall-Pedoe Η (1997) for the WHO MONICA Project. Population versus clinical view of case fatality from acute coronary heart disease: Results from the WHO MONICA Projects 1985-1990. Circulation 96: 3849-3859.

Ditsworth D, Priestley MA, Loepke AW, Ramamoorthy C, McCann J, Staple L, Kurth D (2003) Apoptotic Neuronal Death following Deep Hypothermic Circulatory Arrest in Piglets. Anesthesiology 98: 1119-1127.

Δοντά I (1993) Πειραματισμός στο χοίρο. Οστοΰν 4: 173-178.

Δοντά Ι (1994) Η επιλογή του καταλληλότερου πειραματόζωου ως πειραματικό πρότυπο. Ελληνική Χειρουργική 66: 28-31.

Eisenberg MS, Mengert Τ (2001) Primary care: Cardiac Resuscitation. Ν Eng J Med 344:1304-1313.

Engoren M, Severyn F, Fenn-Buderer Ν, DeFrank M (2002) Cardiac output, coronary blood flow, and blood gases, during open-chest standard and compression-active-decompression cardiopulmonary resuscitation. Resuscitation 55: 309-316.

Escobedo LG, Zack MM (1996) Comparison of sudden and non sudden coronary deaths in the United States. Circulation 93:2033.

Eshel G, Safar P, Sassano J, Stezoski W (1990a) Hyperthermiainduced cardiac arrest in dogs and monkeys. Resuscitation 20:129-143.

Eshel G, Safar P, Stezoski W (1990ß) Evaporative cooling as an adjunct to ice bag use after resuscitation from heat-induced arrest in a primate model. Pediatr Res 27: 264-267.

Eshel G, Safar P, Radovsky A, Stezoski SW (1997) Hyperthermiainduced cardiac arrest in monkeys: limited efficacy of standard CPR. Aviat Space Environ Med 68: 415-420.

Fleischer JE, Nakakimura K, Drummond JC, Serieller MS, Zornow MH, Gräfe MR, Shapiro HM (1992) Effects of levemopamil on neurologic and histologic outcome after cardiac arrest in cats. Crit Care Med 20: 126-134.

Friedman M, Manwaring JH, Rosseman RH, et al (1973) Instantaneous and sudden deaths: Clinical and pathological differentiation in artery disease. JAMA 225: 1319.

Gardner TJ, Johnson DL (1988) Cardiovascular system. In Swindle MM, Adams RJ (eds) Experimental surgery and physiology: induced animal models of human disease. Baltimore: Williams

and Wilkins: 74-124.

Gillette PC; Swindle RP Thompson RP and CL (1991) Case. Transvenous cryoablation of the bundle of His. PACE 14: 504-510.

Gilroy BA, Rockoff MA, Dunlop BJ, Shapiro HM (1980) Cardiopulmonary resuscitation in the nonhuman primate. J Am Vet Med Assoc 177: 867-869.

Gurvitch AM, Mutuskina EA, Novoderzhkina IS (1972) Quantitative evaluation of brain damage in dogs resulting from circulatory arrest to the central nervous system or the whole animal. 2. Electroencephalographic evaluation during early recovery of the gravity and reversibility of post-ischaemic cerebral damage. Resuscitation 1: 219-228

Herweling A, Kamrodi J, Stepniac A, Fein A, Baumgardner JE, Eberle Β, Markstaller Κ (2005) A novel technique to follow variations during experimental CPR. Resuscitation 65: 71-78

Huang L, Weil MH, Cammarata G, Sun S, Tang W (2004) Nonselective beta-blocking agent improves the outcome of cardiopulmonary resuscitation in a rat model. Crit Care Med 32 (Suppl

: S378-380.

Hubert M.B., Salazkin I, Desjardins J, Blaise G (2003) Cardiopulmonary bypass surgery in swine: a research model. J Exp Anim Sci 43: 135-149.

Hughes HC. (1986) Swine in cardiovascular research. Lab Anim Sci 36: 348.

Johansson J, Gedeborg R, Rubertsson S (2004) Vasopressin versus continuous adrenaline during experimental cardiopulmonary resuscitation. Resuscitation 62: 61-69.

Johansson J, Gedeborg R, Basu S, Rubertsson S (2003α) Increased cortical cerebral flow by continuous adrenaline (epinephrine) during experimental cardiopulmonary resuscitation. Resuscitation 57: 299-307.

Johansson J, Ridefelt P, Basu S, Rubertsson S (2003β) Antithrombin reduction after experimental cardiopulmonary resuscitation. Resuscitation 59: 235-242.

Kawahara N, Kawai K, Toyoda T, Nakatomi H, Furuya K, Kirino Τ (2002) Cardiac arrest cerebral ischemia model in mice failed to cause delayed neuronal death in the hippocampus. Neurosci

Lett 322: 91-94.

Kii N, Adachi N, Yorozuya T, Nagaro T, Arai Τ (2000) Suppression of endogenous catecholamine release by anesthetics during cardiopulmonary resuscitation in the rabbit. Can J Anaesth 51:

-405.

Klouche K, Weil MH, Tang W, Povoas H, kamohara T, Bisera J (2002) A selective a2 -adrenergic agonist for cardiac resuscitation. J Lab Clin Med 140: 27-34.

Kofier J., Hattori K, Sawada M, DeVries AC, Martin LJ, Hum PD, Traystman RJ (2004) Histopathological and behavioural characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. Journal of Neuroscience Methods 136: 33-44.

Korth U, Krieter H, Denz C Janke C, Ellinger K, Bertsch T,Henn C, Klein J (2003) Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis. Resuscitation 58: 209-217.

Kuller LH. (1978) Prodromata of sudden death and myocardial infraction. Adv Cardiol 25:61.

Leonov Y, Sterz F, Safar Ρ et al (1990) Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs. J Cereb Blood Flow Metab 10: 57-70.

Link MS, Wang Ρ J, Pandian NG, et al (1998) An experimental model of sudden death due to low-energy chest-wall impact (commotio cordis). An Engl J Med 338: 1805-1811.

Link MS, Maron BJ, Stickney RE, Vandrbrink BA, ZhuWei, Pandian N, Wang PJ, Mark Estes ΝΑ. (2003) Automated external defibrillator arrhythmia detection in a model of cardiac arrest due

to commotio cordis: J Cardiovasc. Electrophysiol 14: 83-87.

Lurie KG,Voelckel GW, Iskos DN, McKnite HS, ZielniskiTM, Sugiyama A,Wenzel V,Bendit D, Linder HK (2002) Combination drug therapy with vasopressin, adrenaline (epinephrine) and nitroglycerin improves vital organ blood flow in a porcine model of ventricular fibrillation Resuscitation 54: 187-194.

Manolio TA, Furberg CD. (1994) Epidemiology of sudden cardiac death. In Akhtar M, Myerburg RJ, Ruskin JN (Eds): Sudden Cardiac Death: Prevalence Mechanisms and Approaches to Diagnosis and Management: Malvern PA, Williams & Wilkins; 3.

Mayr VD, Wenzel V, Voeckel WG, Krismer AC, Mueller T, Lurie KG, Linder HK (2001) Developing a vasopressor combination in a pig model of adult asphyxiai cardiac arrest. Circulation 104:1651-1656.

Menegazzi JJ, Wang HE, Lightfoot CB, Fertig KC, Chengelis NL, Sherman DL, Callaway CW (2003) Immediate defibrillation versus interventions first in a swine model of prolonged ventricular fibrillation. Resuscitation 59: 261-270.

Neigh GN, Glasper ER, Kofier J, Traystman RJ, Mervis RF, Bachsetter A, DeVries AC (2004) Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in CAI pyramidal cells and selectively alters acquisition of spatial memory. Eur J Neurosci 20: 1865-1872.

Nozari A, Safar P, Stezoski SW, Wu X, Henchir J, Radovsky A, Hanson K, Klein E, Kochanek PM, Tisherman SA (2004) Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases concious survival in dogs. Crit Care Med 32: 2110-2116.

Νόμος 2015/1992 (A'30) «Κύρωση της Ευρωπαϊκής Σύμβασης για την προστασία των σπονδυλωτών ζώων που χρησιμοποιούνται για πειραματικούς ή άλλους επιστημονικούς σκοπούς».

Οδηγία 86/609/ΕΟΚ του Συμβουλίου (L. 358) «Για την προσέγγιση των νομοθετικών, κανονιστικών και διοικητικών διατάξεων των Κρατών - Μελών σχετικά με την προστασία των ζώων που χρησιμοποιούνται για πειραματικούς και άλλους επιστημονικούς σκοπούς».

Packer Μ. (1985) Sudden unexpected death in patients with congestive heart failure: A second frontier. Circulation 72: 681.

Προεδρικό Διάταγμα 160/1991 (A'64) «Προστασία των ζώων που χρησιμοποιούνται για πειραματικούς και άλλους επιστημονικούς σκοπούς, σε συμμόρφωση με την Οδηγία 86/609/ΕΟΚ

του Συμβουλίου».

Reid ΚΗ, Paskitti M, Guo SZ, Schmelzer Τ, Iyer V (2003) Experience with ketamine and sodium pentobarbital as anesthetics in a rat model of cardiac arrest and resuscitation. Resuscitation 57: 201-210.

Roine RO, Kajaste S, Kaste M (1993) Neuropsychological sequelae of cardiac arrest. JAMA 269: 237-242.

Safar P, Xiao F, Radovsky A et al (1996) Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke 27: 105-113.

Schmitz Β, Fischer M, Bockhorst Κ, Hoehn-Berlage Μ, Hossmann ΚΑ (1995) Resuscitation from cardiac arrest in cats: influence of epinephrine dosage on brain recovery. Resuscitation 30:251-262.

Schwarz Β, Mair Ρ, Raedler C, Deckert D, Wenzel V, Lindner KH (2002) Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation. Crit Care Med 30:1311-

Studer W, Wu X, Siegemund M, Seeberger M (2002) Resuscitation from cardiac arrest with adrenaline/ epinephrine or vasopressin: effects on intestinal mucosal tonometer pC02 during the post resuscitation period in rats. Resuscitation 53: 201-207.

Su J, Scholz PM, Tse J, Weiss HR (2004) Effects of cyclic GMP and its protein kinase on the contraction of ventricular myocytes from hearts after cardiopulmonary arrest. Can J Physiol Pharmacol 82: 986-992.

Swindle MM. (1998) Cardiothoracic and vascular surgery. In: Surgery, Anesthesia and Experimental Techniques in Swine. Iowa State University Press: 157-202.

Tateishi A, Serieller MS, Drummond JC, Zornow MH, Gräfe MR, Fleischer JE, Shapiro HM (1991) Failure of nimodipine to improve neurologic outcome after eighteen minutes of cardiacarrest in the cat. Resuscitation 21: 191-206.

Tsagalou PE, Anastasiou-Nana IM, Charitos EC, Siafakas XC, Drakos GS, Ntalianis A, Terrovitis VJ (2004) Time course of fibrillation and defibrillation thresholds after an intravenousbolus of amiodarone-an experimental study. Resuscitation 61:83-89.

von Planta I, Weil MH, von Planta M, Bisera J, Bruno S, Gazmuri RJ, Rackow EC (1988) Cardiopulmonary resuscitation in the rat. J Appi Physiol 65: 2641-2647.

Waller BF. (1985) Sudden death in midlife. Cardiovasc Med 10: 55. Weaver ME, Pantely GE, Bristow JD (1986) A quantitative study of the anatomy and distribution of coronary arteries in swine in comparison with other animals and man. Cardiovasc. Res 20:907-917.

Weber H, Berge E, Finch J, Heidt P, Kaup FJ, Perreta G, Verschuere B, Wolfensohn S (1999) Health monitoring of non-human primate colonies. Laboratory Animals 33 (Suppl. 1): S 1:3-S 1:18.

Weis S. (1940) Instantaneous "physiologic" death. N. Engl J Med 223:793.

Wenzel V, Linder KH, Krismer AC, Miller AE, Voelckel WG, Lingau W (1999) Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs. Circulation 99: 1379-1384.

White FC, Roth DM, Bloor CM (1986) The pig as a model for myocardial ischemia and exercise. Lab Anim Sci 36: 351-356.

White FC, Carroll SM, Magnet A (1992) Coronary collateral development in swine after coronary artery occlusion. Circ Res 71: 1450-1500

Wyler F, Rutishauser M, Stalder G (1979) Distribution of cardiac output and organ blood flow in the minipig, an experimental animal for haemodynamic research. Eur J Cardiol 10: 327.

Xu X, Zhou Y, Ma Q, Zhu J, Ma D (1994) Establishing a resuscitation model in rabbits with closed-thoracic cardiopulmonary by-pass. Resuscitation 27: 61-66.

Yannopoulos D, McKnite SH, Tang W, Zook M, Roussos C, Aufderheide T, Idris AH, Lurie KG (2005) Reducing Ventilation Frequency During Cardiopulmonary Resuscitation in a Porcine Model of Cardiac Arrest. Respiratory Care 50: 628-635

Zhang Yi, Boddicker AK, Rhee BJ, Davies LR, Richard KE (2005) Effect of nitric oxide synthase modulation on resuscitation success in a swine ventricular fibrillation cardiac arrest model. Resuscitation 67: 127-134.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 P. LELOVAS, K. MARINOU, Th. XANTHOS, D. PAPADIMITRIOU, D. PERREA, I. DONTAS