Animal models of osteoporosis

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Published: Nov 20, 2017
DOI: https://doi.org/10.12681/jhvms.14936
Keywords:
animal models osteoporosis biomedical research
P. LELOVAS (Π. ΛΕΛΟΒΑΣ)
Laboratory for the Research of Musculoskeletal System, School of Medicine, University of Athens
Abstract

Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial aetiology. A large variety of animal species, such as rodents, rabbits, dogs, sheep and primates, have been used as animal models in osteoporosis research. Their use enhanced our understanding on the etiology of osteoporosis. Additionally, many therapeutic regimes have entered clinical practice after evaluation on animal models. Experimental protocols leading to bone loss include hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, alcohol abuse osteoporosis and osteoporosis induced by food manipulation. Methods of bone mass evaluation, used on animal models, are biochemical markers, densitometry, magnetic resonance imaging, histomorphometry and bone mechanical testing.

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