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Genetically modified food

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F. PAPPAS (Φ. ΠΑΠΠΑΣ), M. STEFANIDOU (Μ. ΣΤΕΦΑΝΙΔΟΥ)
F. PAPPAS (Φ. ΠΑΠΠΑΣ), M. STEFANIDOU (Μ. ΣΤΕΦΑΝΙΔΟΥ)

Abstract


International consensus has been reached on the principles regarding evaluation of the food safety of genetically modified plants. The concept of substantial equivalence has been developed as part of a safety evaluation framework, based on the idea that existing foods can serve as a basis for comparing the properties of genetically modified foods with the appropriate counterpart. Substantial equivalence is a starting point in the safety evaluation, rather than an endpoint of the assessment. The development and validation of new profiling methods, such as DNA microarray technology, proteomics and metabonomics for the identification and characterization of unintended effects, which may occur as a result of the genetic modification, is recommended. The assessment of the allergenicity of newly inserted proteins and of marker genes is discussed. Also, the post-marketing surveillance of the foods derived from genetically modified crops is imperative.


Keywords


genetically modified food; toxicity assessment

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References


Arshad, S. Η., Malmberg, Ε., Krapf, Κ., and Hide, D. W. (1991). Clinical and immunological characteristics of Brazil nut allergy. Clin. Exp. Allergy 21, 373-3767

Astwood, J. D., Leach J. N., and Fuchs, R. L. (1996). Stability of food allergens to digestion in vitro. Nature Biotechnol. 14,1269-1273.

Baynton, C. (1999). Surveillance and Post Market Monitoring of Potential Health Effects of Novel Foods. Feasability Study. London, UK: Food Standards Agency.

Beever, D.E. and Kemp, CF. (2000). Safely issues associated with the DNA in animal feed derived from genetically modified crops. A review of the scientific and regulatory procedures. Nutr. Abstr. Rev. Ser. A, 70,197-204.

CDC (2001). Investigation of human health effects associated with potential exposure to genetically modified corn. A Report to the U.S. Food and Drug Administration from the Centers for Disease Control and Prevention.

CDC (2001a). Development and Use of a Mathod for Detection of IgE Antibodies to Cry9C. June 13, 2001. Atlanta: Centers for Disease Control and Prevention. http://www.cdc.gov/nceh/ehhe/Cry9Creport.

Conner, A. J., and Jacobs, J. M. E. (1999). Genetic engineering of crops as potential source of genetic hazard in the human diet. Mutat. Res. Genet. Tox. Environ. Mutagen. 443, 223-234.

Davies K.G. (2001). What makes genetically modified organisms so distasteful. Trends in Biotechnology, 19, 424-427.

FAO/WHO (2000). Safely aspects of genetically modified foods of plant origin: Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology. Food and Agriculture Organization of the United Nations and World Health Organization. WHO, Geneva, Switzerland.

FAO/WHO (2001). Allergenicity of Genetically Modified Foods. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology. Rome, 22-25 January 2001. Rome:Food and Agriculture Organisation of the United Nations. http://www.fao.org/es/esn/gm/biotec-e.htm.

FDA (1992). Statement of policy: Foods derived from new plant varieties. Food and Drug Administration. Fed. Reg. 57, 22984-23002.

Flavell, R. B., Dart, E., Fuchs, R. L., and Fraley, R. T. (1992). Selectable marker genes: Safe for plants? Biotechnology (N.Y.) 10, 141-144.

Gatehouse, A. M. R., Ferry, N., and Raemaekers, R. J. M. (2002). The case of the monarch butterfly: A verdict is returned. Trends Genet. 18, 249-251.

Goldsbrough, A. P., Tong, Y., and Yoder, J. I. (1996). Le as a nondestructive visual reporter and transposition excision marker gene for tomato. Plant J. 9, 927-933.

Kuiper, Η. Α., Kleter, G. Α., Noteburn, H. P. J. M, and Kok, E. J. (2001). Assessment of the food safety issues related to genetically modified foods. Plant J. 27, 503-528.

Losey, J. E., Rayor, L. S., and Carter, Μ. E. (1999). Transgenic pollen harms monarch larvae. Nature 399, 214.

Lozzia, G. C, Furlanis, C, Manachini, B., and Rigamonti, I. E. (1998). Effects of Bt corn on Rhopalosiphum padi L. (Rhynchota, Aphididae) and on its predator Chrysoperla cornea Stephen (Neuroptera chrysopidae). Boll. Zoo/. Agrar. Bachicolt. 30,153-164.

Maryanski, J. H. (1995). Food and Drug Administration policy for foods developed by biotechnology. In Genetically Modified Foods: Safety Issues (K.-H. Engel, G. R. Takeoka, and R.

Teranishi, Eds.), pp. 12-22. ACS Symposium Series No. 605. American Chemical Society, Washington, DC.

Nordlee, J. Α., Taylor, S. L., Townsend, J. Α., Thomas, L. Α., and Bush, R.K. (1996). Identification of a Brazil-nut allergen in transgenic soybeans. Ν. Engl. J. Med. 334, 688-692.

Noteborn, H.P.J.M., Lommen, Α., Van der Jagt, R.C. and Weseman, J.M. (2000). Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops. J. Biotechnol. 77,103-114.

NRC (2000). Genetically Modified Pest-Protected Plants: Science and Regu-lation. Committee on Genetically Modified Pest-Protected Plants, National Academy Press, Washington D.C.

Pilcher, C. D., Obrycki, J. J., Rice, M. E., and Lewis, L. C. (1997). Preimaginal development, survival, field abundance of insect predators on transgenic Bacillus thuringiensis corn. Environ.

Entomol. 26, 446-454.

Royal Society of Canada (2001). Report of the Expert Panel on the Future of Food Biotechnology. Royal Society of Canada, Ottawa, Ontario.

Sidhu, R.S., Hammond, B.G., Fuchs, R.L.,Mutz, J-N., Holden, L.R., George, B., and Olson, T. (2000). Glyphosate-tolerant corn: The composition and 1 feeding value of grain from glyphosatetolerant corn is equivalent to that of conventional corn (Zea mays L.). J. Agric. Food. Chem. 48, 2305-2312.

Society of Toxicology- Position Paper (2003). The safety of genetically modified foods produced through biotechnology. Toxicological Sciences 71, 2-8.

U.S. EPA (1998). Registration Eligibility Decision (RED): Bacillus thuringiensis. Document EPA738-R-98-004. U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2001). Bacillus thuringiensis Plant-Incorporated Protectants. Biopesticide Registration Action Document, Oct 15, 2001. U.S. Environmental Protection Agency, Washington, DC.

U.S. General Accounting Office (2002). Genetically Modified Foods: Experts vj view regimen of safely tests as adequate, but FDA's evaluation process could be enhanced. Document GAO-02-566.

Wang, Y, Lai, W., Chen, J., Mei, S., Fu, Y., Hu, X. and Zhang, W. (2000). Toxicity of anti-herbicide gene (BAR) transgenic rice. Weisheng Yanjiu, 29, 141-142.


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