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Efficacy and safety of selamectin of flea infestation in dags

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The study was conducted at three dog shekers in Thessaloniki Greece, το confirm die efficacy and safety of selamectin aτ a minimum dosage of 6 mg/kg adminisτered topically as a monthly dose repeaτed three times in die treatment of natural i n f l a t i o n s of Ctenocephalides spp. Twenty (20) dogs, with confirmed naturally acquired flea inflations, were enrolled in die sttidy as primary patiems. All animals completed the study on day 90. Twenty-two in cornai dogs were also treated but not evaluated for efficacy (secondary patiems). There was no untreated group. Only one live adult flea was recovered on only one animal on study day 30, a reduction of die geomettical mean of 99.7 % (p < 0.0001) compared to the sτarτ of die study. Dead fleas were found on 3 animals aτ day 30 (1 or 2 per animal). No live or dead fleas were found on day 60 or on day 90. Ατ sttidy beginning on Day 0, seventy percem of sttidy animals had various clinical signs of flea inflation. These signs gradually decreased and by die end of die sttidy on day 90, only one animal remained widi a score of 1, indicating a low imensity in a single area of die body. All odier animals were free of clinical signs. No abnormal clinical signs or suspend adverse drug reactions were observed after treatment of die 20 primary or die 22 secondary patiems. The daτa collected confirm that under field conditions diree consecutive mondily doses of selamectin are highly effective and safe in die treatment and comrol of fleas in dogs.


Selamectin; Ctenocephalides; dog

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Chesney C.J. Species of fleas found on cats and dogs in south west England: further evidence of their polyxenous state and implications for ilea control. Vet Record 1995,136,356-358

Koutinas A.F., Papazahariadou M.G., Rallis T.S., Tzivara N.H., Himonas C.A. Flea species from dogs and cats in northern Greece: environment and clinical implications. Vet. Parasitology 1995,58,109-115

Rust M.K., Dryden, M.W. The biology, ecology and management of the cat ilea. Annu.Rev. Entomol. 1997,42,451-473.

Kristensen, S., Haarlov N., Mourier H., A study of skin diseases in dogs and cats. IV. Patterns of ilea infestation in dogs and cats in Denmark. Nord. Vet. Med. 1978,30,401-413.

Plant J.D. Recognizing the manifestations of ilea allergy in cats. Vet. Med. 1991,10,482-486.

Saridomichelakis M.N., Koutinas A.F., Gioulekas D. and Leontidis L. Canine atopic dermatitis in Greece: Clinical observations and the prevalence of positive intradermal test reactions in 91 spontaneous cases. Vet Immunol Immunopathol 1999, 69,61-73.

Saridomichelakis M.N., Koutinas A.F. A retrospective study of 10 spontaneous cases of feline atopic dermatitis. Eur J Comp AnimPract2001,11,177-183

Carlotti D.N., Costargent F. Analysis of positive skin tests in 449 dogs with allergic dermatitis. Eur. J. Comput. Ann. Pract. 1994,4, 42-59.

Yeruham I., Rosen S., Hadani A. Mortality in calves, lambs and kids caused by severe infestation with the cat ilea Ctenocephalides felis felis (Bouche, 1835) in Israel. Vet. Parasitol. 1989,30,351-356.

Yaphe W., Giovengo S., Moise N.S. Severe cardiomegaly secondary to anaemia in a kitten. J. Am. Vet. Med. Assoc. 1993,202, 961-964

El-Gazzar L.M., Milio J., Koehler, P.G., Patterson R.S. Insecticide resistance in the cat ilea (Siphonaptera: Pulicidae). J. Econ. Ent. 79,132-134.

Bossard R.L., Hinkle N.C., Rust M.K. Review of insecticide resistance in cat fleas (Siphonaptera: Pulicidae). J. Med. Entomol. 1998,35,415-422.

Bishop B.F, Bruce, C.I., Evans N.A., Goudie, A.C., Gration K.A.F., Gibson S.P., Pacey M.S. Perry D.A., Walshe N.D.A., Witty M.J. Selamectin: a novel broad-spectrum endectocide for dogs and cats. Vet. Parasitol. 2000, 91,163-176.

McTier T.L., Jernigan A.D., Rowan T.G., Holbert M.S., Smothers CD., Bishop B.F., Evans N.A., Gration K.A.F., Giles C.J. Dose selection of selamectin for eficacy against adult flies (Ctenocephalides felis felis) on dogs and cats. Vet. Parasitol. 2000, 91, 177-185.

Beresford-Jones W.P. Prevalence of fleas on dogs and cats in an area of central London. J. Small Anim. Pract. 1981,22, 27-29.

Liebisch von Α., Brandes R., Hoppenstedt Κ. Zum Befall von Hunden und Katzen mit Zecken und Flohen in Deutschland. Prakt. Tierarzt. 1985, 817-824.

Muller von J., Kutschmann K. Flohnachweise (Siphonaptera) auf Hunden im einzugsbereich der Magdeburger Poliklinik fur kleine Haus - und Zootiere Angrew. Parasitol. 1985, 26,197-203.

Franc M., Choquart P., Cadiergues M.C. Repartition des espèces de puces rencontrées chez le chien en France. Rev. Med. 1998, 149,1135-140.

Dryden M.W., Boyer J.E., Smith V., Techinques for estimating on-animal populations of Ctenocephalides felis (Siphonaptera: Pulicidae). J. Med. Entomol. 1994,31, 631-634.

Benchaoui H.A., Clémence R.G., Clements P.J.M., Jones R.L., Watson P., Shanks DJ., Smith D.G., Sture G.H., Jernigan A.D., Rowan T. G. Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe. Vet. Parasitol. 2000,91,223-232.

Heckenberg Κ., Costa S.D, Gregory L.M., Michael B.F. Endris R.G., Shoop W.L. Comparison of thumb-counting and combcounting methods to determine Ctenocephalides felis infestation levels on dogs. Vet. Parasitol. 1994,53,153-157.

Boy M.G., Six R.H., Thomas CA., Novotny M.J., Smothers CD., Rowan T.G., Jernigan A.D. Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Vet. Parasitol. 2000,91,233-250.

Ritzhaupt L.K., Rowan T.G., Jones R.L. Evaluation of efficacy of selamectin, fibronil and imidacloprid against Ctenocephalides felis in dogs. J.Am.Vet.Med.Assoc. 2000, 217(11), 1669-71.

Gregory L.M., Zakson M., Endris R.G., Shoop W.L. A further comparison of the thumb-counting and comb-counting techniques used to determine Ctenocephalides felis infestation levels on

dogs. Vet. Parasitol. 1995,56,349-352.

McTier T.L., Jones R.L., Holbert M.S., Murphy M.G., Watson P., Sun F., Smith D.G., Rowan T.G., Jernigan A.D. Efficacy of selamectin against adult flea infestations {Ctenocephalides felis

felis and Ctenocephalides canis) on dogs and cats. Vet. Parasitol. 2000, 91,187-199.

McTier T.L., Shanks D.J., Jernigan A.D., Rowan T.G., Jones R.L., Murphy M.G., Wang C, Smith D.G., Holbert M.S., Blagburn B.L. Evaluation on the effects of selamectin against adult and immature stages of fleas {Ctenocephalides felis felis) on dogs and cats. Vet. Parasitol. 2000, 91,201-212.

Shanks D.J., Rowan T.G., Jones R.L., Watson P., Murphy M.G., Smith D.G., Jernigan A.D. Efficacy of selamectin in the treatment and prevention of flea {Ctenocephalides felis felis) on dogs

and cats housed in simulated home environments. Vet. Parasitol. 2000, 91, 213-222.

Dryden M.W., Denenberg T.M., Bunch S. Control of fleas on naturally infested dogs and cats and in private residences with topical spot applications of fibronil or imidacloprid. Vet. Parasitol. 2000, 93(1), 69-75.

Jernigan A.D., McTier T.L., Chieffo C, Thomas CA., Krautmann M.J., Hair J.A, Young D.R., Wang C, Rowan T.G. Efficacy of selamectin against experimentally induced tick {Rhipicephalus

sanguineus and Dermacentor variabilis) infestations on dogs. Vet. Parasitol. 2000, 91,359-375.

Payne-Johnson M., Maitland T.P., Sherington J., Shanks D.J., Clements P.J.M., Murphy M.G., McLoughlin A , Jernigan A.D., Rowan T.G. Efficacy of selamectin administered topically to pregnant and lactating female dogs in the treatment and prevention of adult roundworm (Toxocara canis) infestations and flea {Ctenocephalides felis felis) infestations in the dams and their pups. Vet. Parasitol. 2000, 91,347-358.

Novotny M.J., Krautmann M.J., Ehrhart J.C, Godin CS., Evans E.I., McCall J.W., Sun F., Rowan T.G., Jernigan A.D. Safety of selamectin in dogs. Vet. Parasitol. 2000,91,377-391.


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