Possible association between Mycobacterium paratuberculosis infection and Crohn's disease in human

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Published: Jan 31, 2018
DOI: https://doi.org/10.12681/jhvms.15794
Z. DIMARELI-MALLI (Ζ. ΔΗΜΑΡΕΛΛΗ-ΜΑΛΛΗ)
Institute of Infectious and Parasitic Diseases of Thessaloniki, National Agricultural Research Fountation
C. SARRIS (Κ. ΣΑΡΡΗΣ)
Laboratory of Microbiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki
Abstract

Crohn's disease is a granulomatous ileocolitis of humans, of unknown aetiology, which generally manifests itself during the prime of life. The chronic, progressive clinical course and histological findings are consistent wiht a mycobacterial aetiology. Evidence supporting a pathogenic role for a mycobacterium has become available only in the last decade with the isolation of this microorganism from Crohn's disease tissue. M. paratuberculosis, which is the causative agent of Johne's disease in animals, has been identified in patients with Crohn's disease by PCR and DNA hybridisation techniques. It has been shown that isolates of M. paratuberculosis from Crohn's disease are indentical with pathogenic strains in ruminants.

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References
Dalziel Κ. Chronic intestinal enterities. Brit Med J, 1913, 11: 1068-1070.
Chiodini RJ. Mycobacterium Paratuberculosis: an emerging human pathogen. Proceedings of the second Intl Colloq on paratuberculosis. Paris, 1988,141-145.
Lambert JR, Borromeo M. Possible association between Mycobacterium paratuberculosis infection and Crohn's disease in human. Johne's Disease. Milner A, Wood P, eds, CSIRO, Australia 1989,116-120.
Chiodini RJ, Van Kruininger HJ, Merkal RS, Thayer WR, Coutu JA. Characteristics of an unclassified Mycobacterium species isolation from patients with Crohn's disease. J Clin Micobiol 1984, 20: 966-971.
Burnham WR, Lennard-Jones SE, Stanford JL, Bird RG. Mycobacteria as a possible cause of inflammatory bowel disease Lancet 1978, ii: 693-696.
Chiodini RJ, Herbert S, Van Kruiningen HJ, Walter R, Thayer MD, Richard S, Merkal RS, Jessica A, Coutu BA. Possible Role of Mycobacteria in inflammatory Bowel Disease. Dig Dis Sci 1984, 29: 1073-1089.
Graham DY, Markesich DC, Yoshimura HH. Mycobacteria and inflammatory Bowel Disease. Gastroenterology 1987, 92: 436-442.
Gitnick G. Is Crohn's Disease a Mycobacterial Disease After All? Dig Dis Sci 1984, 29: 1086-1088.
Suenaga Κ, Yokoyama Y, Okazaki Κ, Yamamoto Y, Mycobacteria in the intestine of Jampanese patients with inflammatory Bowel Disease. Am J Gastroenterol 1995, 90: 76-80.
Eramus DL, Victor TC, Van Eeden PJ, Van Helden P. Mycobacterium paratuberculosis and Crohn's disease. Gut 1995: 36942.
McFadden JJ, Butcher PD, Chiodini RJ, Herman Taylor J. Determination of genomic size and DNA homology between an unclassified Mycobacterium species isolated from patients with Crohn's disease and other mycobacteria. J Gen Micobiol 1987,133: 211-214.
Sanderson JD, Moss MT, Tizard MLV, Hermon-Taylor J. PCR detection of Mycobacterium paratuberculosis in Crohn;s disease tissue DNA extracts. Proceedings of the Third Intl Colloq on Paratuberculosis Orlando Florida USA 1991, 201-207.
Moss MT, Sanderson JD, Tizard MLV, Hermon-Taylos J, Zaatan F El, Markesich D, Graham D. Indentification of M. paratuberculosis by PCR in long term cultures of
Crohn's disease tissue. Procedings of the Third Intl Colloq on Paratuberculosis Orlando Florida USA 1991, 208-213.
McFadden JJ, Mycobacterium paratuberculosis. A Biological species. "The paratuberculosis Newletter" 1991, Vol. 2 number 1.
Grant IR, Ball HJ, Rowe MT. Heat sensitivity of Mycobacterium paratuberculosis in cows' milk at pasteurization temperatures. "The paratuberculosis Newletter." 1994, vol.6, number 2.
Millar DS, Ford J, Sanderson JD, Tizard MLV, Kempsell K, Lake RJ, Hermon-Taylor J. IS900 PCR testing Mycobacterium paratuberculosis (Mptb) in units of whole pasteurized cows milk widely obtained fron retail outles in Enland and Walew. "The paratuberculosis Newletter". 1994, vol. 6, number 2.
Hermon-Taylor J. From our Huma Paratuberculosis Correspondent. "The paratuberculosis Newletter" 1995, vol 7, number 1.
Hermon-Taylor J. Johne's Bacillus and human Crohn's disease. Proceedings of the Third Intl Colloq on Paratuberculosis Orlando Florida USA 1991,196-200.