Possible association between Mycobacterium paratuberculosis infection and Crohn's disease in human

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Pubblicato: Jan 31, 2018
DOI: https://doi.org/10.12681/jhvms.15794
Z. DIMARELI-MALLI (Ζ. ΔΗΜΑΡΕΛΛΗ-ΜΑΛΛΗ)
Institute of Infectious and Parasitic Diseases of Thessaloniki, National Agricultural Research Fountation
C. SARRIS (Κ. ΣΑΡΡΗΣ)
Laboratory of Microbiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki
Abstract

Crohn's disease is a granulomatous ileocolitis of humans, of unknown aetiology, which generally manifests itself during the prime of life. The chronic, progressive clinical course and histological findings are consistent wiht a mycobacterial aetiology. Evidence supporting a pathogenic role for a mycobacterium has become available only in the last decade with the isolation of this microorganism from Crohn's disease tissue. M. paratuberculosis, which is the causative agent of Johne's disease in animals, has been identified in patients with Crohn's disease by PCR and DNA hybridisation techniques. It has been shown that isolates of M. paratuberculosis from Crohn's disease are indentical with pathogenic strains in ruminants.

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