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A review of the pharmacology of osmotic agents for the treatment of glaucoma in dogs

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T. MAŚLANKA, M. ZUŚKA-PROT
T. MAŚLANKA, M. ZUŚKA-PROT

Abstract


At present, the only proven way to treat glaucoma is to lower intraocular pressure (IOP). Osmotic agents constitute an important class of ocular hypotensive agents. These medications are used for the rapid reduction of IOP, typically in emergency situations, in which IOP is severely elevated and there is a high risk of permanent and irreversible damage of the optic nerve. This paper summarizes the current state of knowledge on the mechanism of action of osmotic agents and their effect on IOP in dogs. Moreover, it discusses the possible undesirable side effects of these medications and presents the current ideas about their role and status in the medical management of canine glaucoma.

Keywords


dogs; glaucoma; intraocular pressure; mannitol; osmotic agents

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References


Anderson DR, Davis EB (1975) Sensitivities of ocular tissues to acute pressure induced ischemia. Arch Ophthalmol 93:267-274

Atkins JM, Wildenthal K,Horwitz LD (1973) Cardiovascular responses to hyperosmotic mannitol in anesthetized and conscious dogs. Am J Physiol 225:132-137

Becker B, Kolker AE, Krupin T (1967) Isosorbide, an oral hyperosmotic agent. Arch Ophthalmol 78:147-150

Borges HF, Hocks J, Kjellstrand CM (1982) Mannitol intoxication in patients with renal failure. Arch Intern Med 142:63-66

Brock KA, Thurmon JC (1979) Pulmonary edema associated with mannitol administration. Canine Pract 6:31-33.Α

Brock KA, Thurmon JC, Benson GJ, Tranquilli WJ (1985) Selected hemodynamic and renal effects of intravenous infusions of hypertonic mannitol in dogs anesthetized with methoxyflurane in oxygen. J Am Anim Hosp Assoc 21:207-214

Cantonnet A (1904) Essai de traitement du glaucome par les substances osmotiques. Arch Ophtal (Par) 24:1-25

Consul BN, Kulshrestha OP (1965) Oral glycerol in glaucoma. Am J Ophthalmol 60:900-907

Craig EL (1994) Glaucoma therapy: osmotic agents. In: (eds: Mauger TF, Craig EL) Havener’s ocular pharmacology, 6th edn., Mosby, St.Louis, pp. 180-200

Drance SM (1964) Effect of oral glycerol of intraocular pressure in normal and glaucomatous ryes. Arch Ophthalmol 72:491-493

Dugan SJ, Roberts SM Severin GA (1989) Systemic osmotherapy for ophthalmic disease in dogs and cats. J Am Vet Med Assoc 194:115-118

Duncan LS, Ellis PP, Paterson CA (1970) Effect of hyperosmotic agents on vitreous osmolality. Exp Eye Res 10:129-132

Duncan LS, Hostetter T, Ellis PP (1969) Vitreous osmolality changes following administration of hyperosmotic agents. Invest Ophthalmol Vis Sci 8:353

Gelatt KN, Brooks DE, Kallberg ME (2007) The canine glaucomas. In: (ed. Gelatt KN) Veterinary Ophthalmology, 4th edn. Blackwell Publishing, Oxford, pp. 753-811

Gilroy BA (1986) Intraocular and cardiopulmonary effects of low-dose mannitol in the dog. Vet Surg 15: 342-344

Hertel E (1914) Experimentelle Untersuchungen über die Abhangigkeit des Augendrucks von der Blutbeschaffenheit. Von Graefes Arch Ophth 88:197-229

Javid M (1958) Urea: New use of an old agent. Reduction of intracranial and intraocular pressure. Surg Clin North Am 38:907-928

Krupin T, Podos SM, Becker B (1973) Alteration of intraocular pressure after third ventricle injections of osmotic agents. Am J Ophthalmol 76:948-952

Kulshrestha OP, Mittal RN (1972) Isosorbide and intraocular pressure. Br J Ophthalmol 56:439-441

Lam KW, Shihab Z, Fu, YA, Lee PF (1980) The effect of optic nerve transaction upon the hypotensive action of ascorbate and mannitol. Ann Ophthalmol 12:1102-1104

Lorimer DW, Hakanson NE, Pion PD, Merideth RE (1989) The effect of intravenous mannitol or oral glycerol on intraocular pressure in dogs. Cornell Vet 79:249-258

Marshall LF, Smith RW, Rauscher LA, Shapiro HM (1978) Mannitol dose requirements in brain-injured patients. J Neurosurg 48:169-172

Maślanka T (2015a) A review of the pharmacology of carbonic anhydrase inhibitors for the treatment of glaucoma in dogs and cats. Vet J 203:278-284

Maślanka T (2014a) Autonomic drugs in the treatment of canine and feline glaucoma - Part I: Medications that lower intraocular pressure by increasing the outflow of aqueous humour. Pol J Vet Sci 17:741-752

Maślanka T (2014b) Autonomic drugs in the treatment of canine and feline glaucoma - Part II: Medications that lower intraocular pressure by reducing aqueous humour production. Pol J Vet Sci 17:753-763

Maślanka T (2015b) Pharmacology of topical prostaglandin F2α analogs and their place in the treatment of glaucoma in small animals. J Vet Pharmacol Ther 38:105-112

Mauger TF, Nye CN, Boyle KA (2000) Intraocular pressure, anterior chamber depth and axial length following intravenous mannitol. J Ocul Pharmacol Ther 16:591-594

Miller PE (2013) The Glaucomas. In: (eds: Maggs DJ, Miller PE, Ofri R) Slatter’s Fundamentals of Veterinary Ophthalmology, 5th edn. Elsevier Saunders, St Louis, pp. 247-271

O’Keeffe M, Nabil M (1983) The use of mannitol in intraocular surgery. Ophthalmic Surg 14:55-56

Podos SM, Krupin T, Becker B (1971) Effect of small-dose hyperosmotic injections on intraocular pressure of small animals and man when optic nerves are transected and intact. Am J Ophthalmol 71, 898-903

Regnier A (2007) Antimicrobials, anti-inflammatory agents, and antiglaucoma drugs. In: (ed: Gelatt KN) Veterinary Ophthalmology, 4th edn. Blackwell Publishing, Oxford, pp. 228-331

Riise D, Simonsen SE (1969) Intraocular pressure in unilateral optic nerve lesion. Acta Ophthalmol (Copenh) 47:750-756

Robbins R, Galin MA (1969) Effect of osmotic agents on the vitreous body. Arch Ophthalmol 82:694-699

Serafano DM, Brubaker RF (1978) Intraocular pressure after optic nerve transection. Invest Ophthalmol Vis Sci 17: 68-71

Serle JB, Danias J, Gagliuso DJ (2003) Hyperosmotic agents. In: (eds: Morrison JC, Pollack IP) Glaucoma: Science and Practice, 1st edn. Thieme, New York, pp. 406-411

Smith LN, Miller PE, Felchle LM (2010) Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs. Am J Vet Res 71:1055-1061

Stamper RL, Lieberman MF, Drake MV (2009) Medical treatment. In (eds: Stamper RL, Lieberman MF, Drake MV) Becker-Shaffer’s Diagnosis and Therapy of the Glaucomas. 8th edn. Mosby Elsevier, St. Louis, pp. 359-435

Toris CB (2010) Pharmacotherapies for glaucoma. Curr Mol Med 10:824-840

Virno M, Cantore P, Bietti C, Bucci MG (1963) Oral glycerol in ophthalmology. A valuable new method for the reduction of intraocular pressure. Am J Ophthalmol 55:1133-1142

Volopich S, Mosing M, Auer U., Nell B. (2006) Comparison of the effect of hypertonic hydroxyethyl starch and mannitol on the intraocular pressure in healthy normotensive dogs and the effect of hypertonic hydroxyethyl starch on the intraocular pressure in dogs with primary glaucoma. Vet Ophthalmol 9, 239-244

Wasserman NT, Kennard G, Cochrane ZN, Felchle LM (2013) Effects of oral isosorbide and glycerol on intraocular pressure, serum osmolality, and blood glucose in normal dogs. Vet Ophthalmol 16:20-24

Weiss DI, Shaffer RN, Harrington DO (1963) Treatment of malignant glaucoma with intravenous mannitol infusion. Medical reformation of the anterior chamber by means of an osmotic agent: a preliminary report. Arch Ophthalmol 69:154-158

Weiss DI, Shaffer RN, Wise BL (1962) Mannitol infusion to reduce intraocular pressure. Arch. Ophthalmol. 68: 341-347

Willis AM (2004) Ocular hypotensive drugs. Vet Clin North Am Small Anim Pract 34:755-776

Wisznia KI, Lazar M, Leopold IH (1970) Oral isosorbide and intraocular pressure. Am J Ophthalmol 70:630-634


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