Paraoxonase activity assessment in dogs suffering from Parvovirus infection

Paraoxonase Parvovirus enteritis acute phase proteins
Canine Parvovirus enteritis is one of the most common causes of diarrhea and death in dogs younger than 6 months of age. Clinical gastroenteritis in parvo-positive dogs is associated with increased levels of lipid peroxides and alteration in antioxidant enzymes. Paraoxonase/arylesterase 1 is considered as an antioxidant enzyme and acute phase protein in laboratory animals and human. The present study evaluated paraoxonase activity in 27 dogs suffering from Parvovirus infection and compared with 9 normal dogs. Blood samples were taken from all of the dogs and were sent to the laboratory for complete cell blood count and also biochemical factors assessment (paraoxonase/arylesterase 1 activity, liver, kidney and metabolic profiles). Infected dogs significantly showed decrease in paraoxonase/arylesterase 1 enzyme activity, an increase number of neutrophils and lymphopenia compared with parvo-negative dogs. Significant decrease in the enzyme activity was also observed in dogs with neutropenia or leukocytosis when compared to control group. It seems that in dogs paraoxonase/arylesterase 1 enzyme activity is decreased as a part of acute phase response in Parvovirus infection.
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