Natural antioxidants improve pulmonary hypertension syndrome and change blood profile in broiler chicken

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Published: Jul 10, 2022
DOI: https://doi.org/10.12681/jhvms.26779
Keywords:
broiler chickens PHS lipid peroxidation antioxidant blood profile
Hamed Zarei
Department of Physiology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
https://orcid.org/0000-0001-5407-9680
Edris Sadr Moghani
Department of Physiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
https://orcid.org/0000-0002-8749-2604
Abstract

The objective of the present study was to investigate the effect of vitamins C and E and garlic powder on hetrophil/lymphocyte and right ventricle (RV)/total ventricle (TV) ratio as well as lipid peroxidation levels in BC with PHS induced by T3 administration. A total of 225 chickens (Ross 308, 1 day old) were randomly divided into five equal groups (n=45) including the control (received standard basal diet (RSBD)+1.5 mg/kg of T3), sham (RSBD over period study), and the vitamin C (RSBD+1200 PPM of vitamin C+1.5 mg/kg of T3), the vitamin E (RSBD+400 mg/kg of vitamin E+1.5 mg/kg of T3), the garlic (RSBD +1% garlic+1.5mg/kg of T3) groups. T3 was administrated at days 7 to 49 of age. At days 21,35 and 49 post- reared, 15 chicks from each group were randomly selected, scarified and blood parameters including lymphocytes, heterophil, hetrophil/lymphocyte and RV/TV ratio as well as lipid peroxidation were assayed. The decreased the RV/TV ratio in the all treatment groups compared to control group indicate that PHS-induced by administration of T3 improve by adding of vitamins E, vitamin C and garlic to basal diet. The highest and lowest mean percentage of heterophil was belonged to the control and sham groups on 35 and 49 days of age, respectively. The highest mean percentage of heterophil/lymphocyte ratio was belonged to the control groups on days of 35, and 49 of age. The adding of vitamin C and garlic to basal diet resulted in a significant increase in the mean percentage of lymphocyte compared to the control and the vitamin E groups on days 35 and 49 of age. In conclusion the natural antioxidants such as garlic, vitamins E and C can improve the increased RV/TV and heterophil/lymphocyte ratios in the blood profile of broiler chickens with PHS due to reduce lipid peroxidation.

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