Natural antioxidants improve pulmonary hypertension syndrome and change blood profile in broiler chicken

PDF (English)
Опубликован: Ιουλ 10, 2022
DOI: https://doi.org/10.12681/jhvms.26779
Hamed Zarei
Department of Physiology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
https://orcid.org/0000-0001-5407-9680
Edris Sadr Moghani
Department of Physiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
https://orcid.org/0000-0002-8749-2604
Аннотация

The objective of the present study was to investigate the effect of vitamins C and E and garlic powder on hetrophil/lymphocyte and right ventricle (RV)/total ventricle (TV) ratio as well as lipid peroxidation levels in BC with PHS induced by T3 administration. A total of 225 chickens (Ross 308, 1 day old) were randomly divided into five equal groups (n=45) including the control (received standard basal diet (RSBD)+1.5 mg/kg of T3), sham (RSBD over period study), and the vitamin C (RSBD+1200 PPM of vitamin C+1.5 mg/kg of T3), the vitamin E (RSBD+400 mg/kg of vitamin E+1.5 mg/kg of T3), the garlic (RSBD +1% garlic+1.5mg/kg of T3) groups. T3 was administrated at days 7 to 49 of age. At days 21,35 and 49 post- reared, 15 chicks from each group were randomly selected, scarified and blood parameters including lymphocytes, heterophil, hetrophil/lymphocyte and RV/TV ratio as well as lipid peroxidation were assayed. The decreased the RV/TV ratio in the all treatment groups compared to control group indicate that PHS-induced by administration of T3 improve by adding of vitamins E, vitamin C and garlic to basal diet. The highest and lowest mean percentage of heterophil was belonged to the control and sham groups on 35 and 49 days of age, respectively. The highest mean percentage of heterophil/lymphocyte ratio was belonged to the control groups on days of 35, and 49 of age. The adding of vitamin C and garlic to basal diet resulted in a significant increase in the mean percentage of lymphocyte compared to the control and the vitamin E groups on days 35 and 49 of age. In conclusion the natural antioxidants such as garlic, vitamins E and C can improve the increased RV/TV and heterophil/lymphocyte ratios in the blood profile of broiler chickens with PHS due to reduce lipid peroxidation.

Article Details
  • Раздел
  • Research Articles
Лицензия Creative Commons

Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial» («Атрибуция — Некоммерческое использование») 4.0 Всемирная.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Скачивания
Данные скачивания пока недоступны.
Библиографические ссылки
Ahmadipour B, Hassanpour H, Asadi E, Khajali F, Rafiei F, Khajali F. (2015) Kelussia odoratissima Mozzaf- A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude. J Ethnopharmacol. 159(1):49-54
Abidin Z, Khatoon A. (2013) Heat stress in poultry and the beneficial effects of ascorbic acid (vitamin C) supplementation during periods of heat stress. World's Poul Sci J. 69(1):135-152.
Antolovich M, Prenzler PD, Patsalides E, McDonald S, Robards K. (2002) Methods for testing antioxidant activity. Analyst. 127:183-198
Arab HA, Jamshidi R, Rassouli A, Shams G, Hassanzadeh MH. (2006) Generation of hydroxyl radicals during ascites experimentally induced in broiler. Br Poult Sci. 47(2), 216-222.
Arun P, Gita C. (2014) Role of Vitamin E in Counteracting Oxidative Stress in Poultry. J Poul Sci. 51: 109-117
Azis A. (2012). Performance and Heterophil to Lymphocyte (H/L) Ratio Profile of Broiler Chickens Subjected to Feeding Time Restriction. Int J Poul Sci. 11: 153-157.
Chang C, Lin MJ, Croom J, Fan KY. (2003) Administration of Triiodothyronine and Dopamine to Broiler ChicksIncreases Growth, Feed Conversion and Visceral Organ Mass. Poul Sci. 82:285–293
Chen H, Wang X, Fan T, Li J, Wang L, Shen Z (2014) A case of veno-occlusive disease following liver transplantation. Exp Therap Med. 7:141–144
Faraji M, Karimi Dehkordi S, Zamiani Moghadam A, Ahmadipour B, Khajali F. (2019) Combined effects of guanidinoacetic acid, coenzyme Q10 and taurine on growth performance, gene expression and ascites mortality in broiler chickens. J Anim Physiol Anim Nutr (Berl). 103(1):162-169.
Fathi M, Nazer adl K, Ebrahim Nezhad Y, Aghdam Shahryar H, Daneshyar M, Tanha T. (2011) The Role of Oxidative Stress in Development of Congestive Heart Failure (CHF) in Broiler with Pulmonary Hypertension Syndrome (PHS). J Anim Vet Adv. 10:2724-2729.
Fazlolahzadeh F, Keramati K, Nazifi S, Shirian S, Seifi S. (2011). Effect of Garlic(Allium sativum) on Hematological Parameters and Plasma Activities of ALT and AST of Rainbow trout in Temperature Stress. Aus J Basic Applied Sci. 5 (9), 84-90
Gao J, Lin H, Wang XJ, Song ZG, Jiao HC. (2010) Vitamin E supplementation alleviates the oxidative stress induced by dexamethasone treatment and improves meat quality in broiler chickens. Poult. Sci. 89:318-327.
Gautam N, Subhasis Das S, Mahapatra SK, Chakraborty SKP, Kundu PK, Roy S (2010). Age associated oxidative damage in lymphocytes. Oxid Med Cell Longev. 3(4): 275–282.
Gurbanov E, Shiliang X. (2006) The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. Eur J Cardio-Thoracic Surg. 30: 499–507.
Habibian M, Sadeghi G, Karimi A. (2017) Effects of purslane (Portulaca oleraceaL.) powder ongrowth performance, blood indices, and antioxidantstatus in broiler chickens with triiodothyronine-inducedascites . Arch Anim Breed. 60: 315–325.
Hasani A, Bouyeh M, Rahati M, Seidavi A, Makovichy P, Laudadio V, Tufarelli V. (2018) Which is the best alternative for ascites syndrome prevention in broiler chickens? Effect of feed form and rearing temperature conditions. J Applied Anim Res. 46(1): 392-396.
Hassanpour H, Teshfam M, Momtaz H, Zarei H, Bahadoran S. (2014) Caspase-1, -2, and -3 gene expression is enhanced in the heart and lung of chickens with pulmonary hypertension (ascites). Turkish J Vet Anim Sci. 38(2):133-137
Lara LJ, Rostagno MH. (2013) Impact of heat stress on poultry production. Animals. 3(2):356-369
Nemati MH, Shahir MH, Harakinezha MT. (2017) Cold-Induced Ascites in Broilers: Effects of Vitamin C and Coenzyme Q10. Braz J Poul Sci. 19: 537-544
Özkan S, Basmacioğlu Malayoğlu H, Yalçin S , Karadaşb F, Koçtürk S, çabuk M , Oktay G , Özdemir S , Özdemir E, Ergül M. (2007) Dietary vitamin E (α-tocopherol acetate) and selenium supplementation from different sources: performance, ascites-related variables and antioxidant status in broilers reared at low and optimum temperatures. British Poultry Science. 48:5, 580-593
Pan JQ, Tan X, Li JC, Sun WD, Wang XL. (2005) Effects of early feed restriction and cold temperature on lipid peroxidation, pulmonary vascular remodelling and ascites morbidity in broilersunder normal and cold temperature. British Poultry Science. 46, 374381
Peng Z, Wang YW, Ning D, Guo YM. (2013) Changes of haematic parameters, redox status andmitochondrial complex activity in the heart and liver ofbroilers fed with different density diets under low ambient temperature. Avian Pathology. 42:327-334
Pompeu MA, Cavalcanti LFL, Toral FLB. (2018) Effect of vitamin E supplementation on growth performance, meat quality, and immune response of male broiler chickens: A meta-analysis. Livestock Science. 208:5-13
Sahin K, Orhan C, Smith MO, Sahin N. (2013) Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry. World's Poultry Science Journal. 69(1):113-123.
Selim A, Youssef SF, Abdel-Salam AF, Nada SA. (2013) Evaluations of some natural antioxidant sources in broiler diets: 1-effect on growth, physiological and immunological performance of broiler chicks. Int J Poult Sci. 12: 561-571
ŞENAY S, ISLIM P, TUGAY A. (2019) Supplementation of Natural Antioxidants to Reduced Crude Protein Diets for Japanese Quails Exposed to Heat Stress. Braz J Poult Sci. 21: eRBCA-2019-0694
Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH, Pintus G. (2020) Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety. Front. Pharmacol. 2020; 11
Varmaghany S, Karimi Torshizi MA, Rahimi S, Lotfollahian H, Hassanzadeh M. (2015) The Effects of Increasing Levels of Dietary Garlic Bulb on Growth Performance, Systolic Blood Pressure, Hematology, and Ascites Syndrome in Broiler Chickens. Poult Sci. 94(8):1812-20
Vaziri ND, NI Z, Trnavsky-Hobbs DL, Oveisi F. (2000) Effect of Antioxidant Therapy on Nitric Oxide Synthase (NOS) Expression in Hypertensive Rats. Hypertention. 36:705
Walton JP, Julian RJ, Squires EJ. (2001) The effect of dietaryflax oil and antioxidants on ascites and pulmonary hypertensionin broilers using a low temperature model. Brit Poultry Sci. 42:123–129
Wideman RF, Rhoads DD, Erf GF, Anthony NB. (2013) Pulmonary arterial hypertension - (ascites syndrome) in broilers: a review. Poultry Sci. 92:64–83.