Oxidative Stress and Acute-Phase Response Status During Treatment in Premature Calves with Respiratory Distress Syndrome

PDF
DOI: https://doi.org/10.12681/jhvms.28521
Keywords:
respiratory distress syndrome premature calf oxidative stress markers acute-phase response
M OK
The Department of Internal Medicine, Faculty of Veterinary Medicine, SelcukUniversity, Konya, Turkey
R YILDIZ
The Department of Internal Medicine, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
B TRAŞ
The Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, SelcukUniversity, Konya, Turkey
P COSKUN
The Department of Biochemistry, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
A AKAR
The Department of Internal Medicine, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
Abstract

This study aimed to determine lipid peroxide (LPO), antioxidant capacity (AOC), and acute-phase protein changes before and after different nebulization treatments in premature calves with respiratory distress syndrome (RDS). Thirty-six premature calves were divided into equal number of 6 groups. Group 1 was labelled as negative control and received standard treatment. Group 2 was labelled as positive control; Groups 3, 4, 5, and 6 were labelled as trial groups. These groups received nebulizer treatment. Nebulizer drug combinations were as follows: Group 2 (fluticasone), Group 3 (formoterol + fluticasone), Group 4 (ipratropium bromide + fluticasone), Group 5 (fluticasone + furosemide) and Group 6 (formoterol + ipratropium bromide + furosemide + fluticasone). Venous blood was taken from all calves before (0 hour) and after treatment (24th, 48th, 72nd hour). It was concluded that total LPO levels gradually decreased while AOC levels increased during treatment but there was no difference in the serum amyloid A (SAA) and fibrinogen levels within groups. In conclusion, supportive and nebulizer treatments to improve function of lungs were demonstrated to alleviate oxidative stress. However, in order to reveal the effects of local nebulizer applications on oxidative stress, further studies are required to investigate oxidation parameters in the bronchoalveolar fluid.

Article Details
  • Section
  • Research Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
References
Ahola T, Levonen AL, Fellman V, Lapatto R (2004) Thiol metabolism in preterm infants during the first week of life. Scand J Clin Lab Invest 64 (7): 649-58.
Auten RI, Davis JM (2009) Oxygen toxicity and reactive oxygen species: The devil is in the details. Pediatric Research 66: 121-7.
Avery M E, Merrit T A (1991) Surfactant-replacement therapy. North England Journal Medicine 324: 910-2.
Aydogdu U, Yildiz R, Guzelbektes H, Coskun A, Sen I (2016) Cardiac biomarker in premature calves with respiratory distress syndrome. Acta Veterinarina Hungarica 64 (1): 38-46.
Ballard PL, Truog WE, Merrili JD, Gow A (2008) Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics 121: 555-561.
Buhimschi IA, Buhimschi CS, Pupkin M, Weiner CP (2003) Beneficial impact of term labor: nonenzymatic antioxidant reserve in the human fetus. Am J Obstet Gynecol 189 (1): 181-8.
Buonocore G, Perreno S, Longini M, Vezzosi P, Marzocchi B, Pafetti P, Bracci R (2002) Oxidative stress in preterm neonates and on the seventh day of live. Pediatrics Research 52 (1): 46-9.
Cantin AM, North SL, Hubbard RC, Crystal RG (1987) Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 63: 152-7.
Carole L, Linster CL, Van Schaftingen E (2007) Vitamin C: Biosynthesis, recycling and degradation in mammals. FEBS Journal. 274(1):1-22. doi:10.1111/j.1742-4658.2006.05607.x.
Davis JM, Auten RL (2010) Maturation of the antioxidant system and the effects on preterm birth. Semin Fetal Neonatal Med. Deaton CM (2006) The Role of oxidative stress in equine models of human asthma. Redox Reports 11: 46-52.
Dennery PA (2004) Role of redox in fetal development and neonatal diseases. Antioxid Redox Signal 6 (1): 147-53.
Eckersall PD, Bell R (2010) Acute phase proteins: biomarkers of infection and inflammation in Veterinary Medicine. The Veterinary Journal 185: 23-7.
Frank L (1992) Antioxidants, nutrition, and bronchopulmonary dysplasia. Clinics in Perinatology 19 (3): 541-62.
Georgeson GD, Szony BJ, Streitman K, Varga IS, Kovacs A et al. (2002) Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. Eur J Obstet Gynecol Reprod Biol 103 (2): 136-9.
Grobben DZ, Lindeman JHN, Houdkamp E, Moison RMW, Wijnen JT, Berger HM (1997) Markers of oxidative stress and antioxidant activity in plasma and erythrocytes in neonatal respiratory distress syndrome. Acta Pediatrics 86: 1356-1362.
Gulcin, I (2020) Antioxidants and antioxidant methods: an updated overview Archives of Toxicology volume 94, 651-715.
Gulcin I, Oktay M, Koksal E, Serbetci H, Beydemir S, Kufrevioglu OI (2008) Antioxidant and radical scavenging activities of uric acid. Asian J Chem 20:2079-2090.
Gutteridge JM (1995) Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry 41 (12): 1819-1828.
Guzelbektes H, Coskun A, Ok M, Aydogdu U, Sen I (2012) Prevalence of gastroesophageal reflux disease in premature calves. Journal Veterinary Internal Medicine 26(4): 1051-5.
Halliwell B (1997) Antioxidants in human health and disease. Ann Rev Nut 16:33-50.
Hirano K, Morinobu T, Kim H, Hiroi M, Ban R et al. (2001) Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Archives of disease in childhood. Fetal and neonatal edition 84 (3): F188-93.
Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidise (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine. 54:287-293. doi: 10.1016/j.ajme.2017.09.001.
Jain A, Mehta T, Auld PA, Rodrigues J, Ward RF et al. (1995) Glutathione metabolism in newborns: evidence for glutathione deficiency in plasma, bronchoalveolar lavage fluid, and lymphocytes in prematures. Pediatr Pulmonol 20 (3): 160-6.
Jean-Baptiste D, Rudolph N (2003) Sequential postnatal changes in erythrocyte glutathione and sulfhydryl content: a possible adaptational response to the extrauterine environment. Biol Neonate 84 (2): 142-6.
Johanson JM, Berger PJ (2003) Birth weight as a predictor of calving ease and perinatal mortality in holstein cattle. Journal Dairy Science 86:3745-3755.
Kapoor K, Basu S, Das BK, Bhatia BD (2006) Lipid peroxidation and antioxidants in neonatal septicemia. J Trop Pediatr 52 (5): 372-5.
Kim SJ, Kim KH, Kang HS, Kim JS, Kim MH et al. (2012) Effectiveness of antioxidant and membrane oxygenator in acute respiratory distress syndrome by endotoxin. Korean Journal Chemistry Engla 29 (11):1597-1603.
Konduri GG, Kim UO (2009) Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatric Clinical North America 56 (3): 579-600.
Laborie S, Lavoie JC, Chessex P (2000) Increased urinary peroxides in newborn infants receiving parenteral nutrition exposed to light. J Pediatr 136 (5): 628-32.
Lewandowski KC, Stojanovic N, Press M, Tuck S, Lewinski A et al. (2014) Raised concentrations of lipid peroxidation products (LPO) in pregnant women with impaired glucose tolerance. Annals of Agricultural and Environmental Medicine, 21(2). Lichtenstern C, Hofer S, Möllers A, Ramos SR, Martin DS et al. (2011) Lipid peroxidation in acute respiratory distress syndrome and liver failure. Journal Surgery Research 168: 243-252.
Lomaestro B, Malone M (1995) Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother 29: 1263-73.
Lomborg SR, Neilsen LR, Heegard PM (2008) Acute phase proteins after exposure to complex stress. Veterinary Research Communications 32: 575-582.
Lykkesfeldt J, Svendes O (2007) Oxidant and antioxidants in disease: Ox idative stress in farm animals. The Veterinary Journal 173: 502-511.
Maden M, Ozturk AS, Bulbul A, Avci AE, Yazar E (2012) Acute phase proteins, oxidative stress, and enzymes activities of blood serum and peritoneal fluid in cattle with abomasal displacement. J Vet Intern Med 26: 1470-1475.
Martinez-Subiela S, Tecles F, Ceron JJ (2003) Critical differences of acute phase proteins in canine serum samples. The Veterinary Journal 166:233-7.
McGrotty YL, Arteaga A, Knottenbelt CM, Ramsey IK, Eckersall PD (2005) Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology 34: 255-8.
Meyer CL, Berger PJ, Koehler KJ, Thompson JR, Sattler CG (2001) Phenotypic trends in incidence of stillbirth for holstein in the United States. Journal of Dairy Science 84: 1246-1254.
Moison RM, van Hoof EJ, Clahsen PC, van Zoeren-Grobben D, Berger HM (1996) Influence of plasma preparations and donor red blood cells on the antioxidant capacity of blood from newborn babies: an in vitro study. Acta Paediatr 85 (2): 220-4.
Murata H, Shimada N, Yoshioka M (2004) Current research on acute phase proteins in veterinary diagnosis: an Overview. The Veterinary Journal 168: 28-40.
Mutinati M, Pantaleo M, Roncetti M, Piccinno M, Rizzo A et al. (2014) Oxidative stress in neonatology. A Review Reprod Dom Anim 49: 7-16.
Ok M, Yildiz R, Tras B, Baspınar N, Akar A (2020) Effect of nebulized formeterol, ipratropium bromid, and furosemid in combination with fluticasone propionate on arterial blood gases prematüre calves with respiratory distres syndrome. J Hellenıc Vet Med Soc 71 (1): 2011-2018.
Perrone S, Mussap M, Longini M, Fanos V, Bellieni CV et al. (2007) Oxidative kidney damage in preterm newborns during perinatal period. Clinical biochemistry (9-10): 656-60.
Rook D (2013) Less Stress: Oxidative Stress and Glutathione Kinetics in Preterm Infants. Rotterdam, The Netherlands: Optima Grafische Communicatie.
Sustronck B, Van Loon G, Gasthuys F, Foubert L, Deprez P et al. (1996) Effect of the inhalation of nitric oxide on 5-hydroxytryptamine-induced pulmonary hypertension in calves. Zentralbl Veterinarmed A 43 (9): 513-520.
von Dessauer B, Bongain J, Molina V, Quilodran J, Castillo R et al. (2010) Oxidative stress as a novel target in pediatric sepsis management. J Crit Care 26(1), 103-e1.
Yildiz R, Ok M, Ider M, Akar A, Naseri A et al. (2019) The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome. Veterinarni Medicina 64 (10): 440-447.
Yildiz R, Ok M (2017) Clinical efficacy of combinations of nebulized fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome. Veterinarni Medicina 62 (10): 541-552.
Yun CH, Wynn P, Ha JK (2014) Stress, acute phase proteins and immune modulation in calves. Animal production science, 54(10), 1561-1568.
Most read articles by the same author(s)