Pathological and Molecular Investigations in the Aborted Fetal Lamb due to the Poxvirus

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Published: Apr 22, 2024
DOI: https://doi.org/10.12681/jhvms.32180
Keywords:
Abortion Molecular Pathology Ovine fetus
E Beytut
Department of Pathology and Virology, Faculty of Veterinary Medicine, University of Kafkas, Kars/Turkey
N Coskun
Kafkas University
https://orcid.org/0000-0001-7642-6460
S Dag
Kafkas University
https://orcid.org/0000-0001-7667-689X
H Nuhoglu
Kafkas University
https://orcid.org/0000-0003-2530-2542
E Karakurt
Kafkas University
https://orcid.org/0000-0003-2019-3690
V Yilmaz
Kafkas University
https://orcid.org/0000-0003-2752-5360
A Yildiz
Kafkas University
https://orcid.org/0000-0002-6569-5435
Abstract

In this case, the sheeppox virus strain-induced abortion in a ewe and fetal lesions are reported. At the necropsy, pock nodules of varying sizes were seen to scatter over the skin and lungs of the fetus. Histological examination of the pock nodules from the skin and the lungs found typical sheeppox cells and cytoplasmic inclusion bodies. Immunohistochemistry to surfactant proteins (SP) and multi-cytokeratin (MCK) confirmed hyperplasia of type II cells and bronchial lining epithelium in the pock nodes. A polymerase chain reaction (PCR) test using skin nodules confirmed the causing agent is a Capripoxvirus. The phylogenetic comparison of the sheeppox virus (SPPV), goatpox virus (GPPV), and lumpy skin disease virus (LSDV) revealed that the reason for abortion was the sheeppox virus strain.

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