english


Δημοσιευμένα: Φεβ 12, 2026
V Zapridis
K Varkoulis
G Kirmanidou
I Tzortzi
G Kazakos
I Savvas
T Anagnostou
Περίληψη

The aim of this study was to investigate if propofol requirements for induction of anaesthesia are lower in paediatric and geriatric dogs and cats than in adults. Based on 5-year retrospective data, 3,266 dogs’ and 606 cats’ anaesthetic records were included in the study. Animals induced with propofol were grouped according to premedication and age. A Kolmogorov-Smirnov test revealed non-parametric data, while a Kruskal-Wallis and a Mann-Whitney test were used for comparisons. Paediatric and geriatric animals required significantly different propofol doses compared to adults. Premedication type and indication for anaesthesia also influenced propofol dose requirements. According to our study neonatal and paediatric dogs and cats require a higher dose of propofol for induction of anaesthesia when compared to adults and geriatrics, while geriatric patients require a lower dose compared to other groups. This finding comes in contrast to suggestions in veterinary literature that paediatric patients require a lower dose of propofol compared to adult animals. When propofol is used as a sole agent for induction of anaesthesia, patient age can affect the total amount of drug used.


 

Λεπτομέρειες άρθρου
  • Ενότητα
  • Άρθρα
Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Adembri, C., Venturi, L., Pellegrini‐Giampietro, D.E., 2007. Neuroprotective
Effects of Propofol in Acute Cerebral Injury. CNS
Drug Reviews 13, 333–351. https://doi.org/10.1111/j.1527-
2007.00015.x
Amaniti, A., 2012. Anaesthesia in paediatric patients, in: Anaesthesia
and Intensive care. Rotonda, Thessaloniki, pp. 367–381.
Aun, C.S.T., Short, S.M., Leung, D.H.Y., Oh, T.E., 1992. INDUCTION
DOSE-RESPONSE OF PROPOFOL IN UNPREMEDICATED
CHILDREN. British Journal of Anaesthesia 68, 64–67. https://
doi.org/10.1093/bja/68.1.64
Baetge, C.L., Matthews, N.S., 2012. Anesthesia and Analgesia for
Geriatric Veterinary Patients. Veterinary Clinics of North America:
Small Animal Practice 42, 643–653. https://doi.org/10.1016/j.
cvsm.2012.05.001
Bester, Lynett, 2009. Pharmacokinetics of propofol in cats (Master of
Veterinary Medicine (Anaesthesia) Thesis). University of Pretoria,
South Africa.
Butterworth, John F.; Mackey, David C.; Wasnick, John D., 2013. Intravenous
Anesthetics, in: Morgan and Mikhail’s Clinical Anesthesiology.
McGraw-Hill Education, New York, pp. 175–189.
Chatdarong, K., Ponglowhapan, S., Manee-in, S., Pongphet, K., 2006.
The use of propofol for electroejaculation in domestic cats. Theriogenology
01.006
Eger, E.I., 2001. Age, Minimum Alveolar Anesthetic Concentration,
and Minimum Alveolar Anesthetic Concentration-Awake. Anesthesia
& Analgesia 93, 947–953. https://doi.org/10.1097/00000539-
-00029
Eleveld, D.J., Proost, J.H., Cortínez, L.I., Absalom, A.R., Struys,
M.M.R.F., 2014. A General Purpose Pharmacokinetic Model for
Propofol. Anesthesia & Analgesia 118, 1221–1237. https://doi.
org/10.1213/ANE.0000000000000165
Gan, T.J., Glass, P.S., Sigl, J., Sebel, P., Payne, F., Rosow, C., Embree,
P., 1999. Women Emerge from General Anesthesia with Propofol/
Alfentanil/Nitrous Oxide Faster than Men. Anesthesiology 90,
Grubb, Tamara L.; Perez Jimenez, Teresa E.; Pettifer, Grant R., 2015a.
Neonatal and Pediatric Patients, in: Veterinary Anesthesia and Analgesia:
The Fifth Edition of Lumb and Jones. John Wiley & Sons,
Ames, IA, pp. 983–987.
Grubb, Tamara L.; Perez Jimenez, Teresa E.; Pettifer, Grant R., 2015b.
Senior and Geriatric Patients, in: Veterinary Anesthesia and Analgesia:
The Fifth Edition of Lumb and Jones. John Wiley & Sons,
Ames, IA, pp. 988–992.
Guedes, A.G.P., Meadows, J.M., Pypendop, B.H., Johnson, E.G., 2018.
Evaluation of tramadol for treatment of osteoarthritis in geriatric
cats. J Am Vet Med Assoc 252, 565–571. https://doi.org/10.2460/
javma.252.5.565
Hammond, R.A., England, G.C.W., 1994. The effect of medetomidine
premedication upon propofol induction and infusion anaesthesia
in the dog. Journal of Veterinary Anaesthesia 21, 24–28. https://
doi.org/10.1111/j.1467-2995.1994.tb00478.x
Hampton, C.E., Da Cunha, A., Desselle, A., Queiroz-Williams, P., Hofmeister,
E.H., 2023. The effect of age on the induction dose of
propofol for general anesthesia in dogs. PLoS ONE 18, e0288088.
Henao-Guerrero, N., Riccó, C.H., 2014. Comparison of the cardiorespiratory
effects of a combination of ketamine and propofol, propofol
alone, or a combination of ketamine and diazepam before and after
induction of anesthesia in dogs sedated with acepromazine and oxymorphone.
References
Hoymork, S.C., Raeder, J., 2005. Why do women wake up faster than
men from propofol anaesthesia? British Journal of Anaesthesia 95,
Hughes, J.M.L., 2008. Anaesthesia for the geriatric dog and cat. Ir Vet
Jasiak, K.D., Phan, H., Christich, A.C., Edwards, C.J., Skrepnek, G.H.,
Patanwala, A.E., 2012. Induction Dose of Propofol for Pediatric
Patients Undergoing Procedural Sedation in the Emergency Department:
Pediatric Emergency Care 28, 440–442. https://doi.
org/10.1097/PEC.0b013e3182531a9b
Jia, L., Hou, J., Zheng, H., Sun, L., Fan, Y., Wang, X., Hao, M., Li, Y.,
Yang, T., 2020. Study of the rational dose of propofol in elderly
patients under bispectral index monitoring during total intravenous
anesthesia: A PRISMA-compliant systematic review. Medicine 99,
Karamichali, P., Anagnostou, T., Kazakos, G.M., Prassinos, N., Dimopoulou,
I., Savvas, I., 2023. Effect of gonadectomy on pain
assessment in dogs undergoing orthopaedic stifle surgery. Veterinary
Anaesthesia and Analgesia 50, 430–438. https://doi.org/10.1016/j.
vaa.2023.05.002
Kirkpatrick, T., Cockshott, I.D., Douglas, E.J., Nimmo, W.S., 1988.
PHARMACOKINETICS OF PROPOFOL (DIPRIVAN) IN ELDERLY
PATIENTS. British Journal of Anaesthesia 60, 146–150.
Kodaka, M., Johansen, J.W., Sebel, P.S., 2005. The Influence of Gender
on Loss of Consciousness with Sevoflurane or Propofol: Anesthesia
& Analgesia 101, 377–381. https://doi.org/10.1213/01.
ANE.0000154534.71371.4F
Laflamme, Dottie., 1997. Development and validation of a body condition
score system for dogs. Canine Practice 22, 10–15.
Larsson, J.E., Wahlström, G., 1998. The influence of age and administration
rate on the brain sensitivity to propofol in rats. Acta Anaesthesiol
tb05360.x
Marsh, B., White, M., Morton, N., Kenny, G.N.C., 1991. PHARMACOKINETIC
MODEL DRIVEN INFUSION OF PROPOFOL IN
CHILDREN. British Journal of Anaesthesia 67, 41–48. https://doi.
org/10.1093/bja/67.1.41
Olby, N.J., Da Costa, R.C., Levine, J.M., Stein, V.M., The Canine Spinal
Cord Injury Consortium (CANSORT SCI), 2020. Prognostic Factors
in Canine Acute Intervertebral Disc Disease. Front. Vet. Sci. 7,
Pascoe, P.J., Moon, P.F., 2001. Periparturient and Neonatal Anesthesia.
Veterinary Clinics of North America: Small Animal Practice 31,
Pleym, H., Spigset, O., Kharasch, E.D., Dale, O., 2003. Gender differences
in drug effects: implications for anesthesiologists. Acta
Anaesthesiol Scand 47, 241–259. https://doi.org/10.1034/j.1399-
2003.00036.x
Redondo, J.I., Otero, P.E., Martínez-Taboada, F., Doménech, L., Hernández-
Magaña, E.Z., Viscasillas, J., 2024. Anaesthetic mortality in
dogs: A worldwide analysis and risk assessment. Vet Rec 195,
Reid, J., 1996. Pharmacokinetics of propofol as an induction agent in
geriatric dogs. Research in Veterinary Science 61, 169–171. https://
doi.org/10.1016/S0034-5288(96)90095-8
Rigotti, C.F., Brearley, J.C., 2016. Anaesthesia for paediatric and geriatric
patients, in: Duke-Novakovski, De Vries, Seymour (Eds.),
BSAVA Manual of Canine and Feline Anaesthesia and Analgesia.
British Small Animal Veterinary Association, pp. 418–427. https://
doi.org/10.22233/9781910443231.30
Sahinovic, M.M., Struys, M.M.R.F., Absalom, A.R., 2018. Clinical Pharmacokinetics
and Pharmacodynamics of Propofol. Clin Pharmacokinet
Shafer, A., Doze, V.A., Shafer, S.L., White, P.F., 1988. Pharmacokinetics
and Pharmacodynamics of Propofol Infusions during
General Anesthesia. Anesthesiology 69, 348–356. https://doi.
org/10.1097/00000542-198809000-00011
Siegal, M., Barlough, J.E., 1995. UC Davis book of dogs: the complete
medical reference guide for dogs and puppies, 1st ed. ed. Harper-
Collins Publishers, New York.
Urfer, S.R., Kaeberlein, M., Promislow, D.E.L., Creevy, K.E., 2020.
Lifespan of companion dogs seen in three independent primary care
veterinary clinics in the United States. Canine Genet Epidemiol 7,
Vuyk, J., Oostwouder, C.J., Vletter, A.A., Burm, A.G.L., Bovill, J.G.,
Gender differences in the pharmacokinetics of propofol in
elderly patients during and after continuous infusion. British Journal
of Anaesthesia 86, 183–188. https://doi.org/10.1093/bja/86.2.183
Weaver, B.M., Raptopoulos, D., 1990. Induction of anaesthesia in dogs
and cats with propofol. Vet Rec 126, 617–620.
Τα περισσότερο διαβασμένα άρθρα του ίδιου συγγραφέα(s)