Comparative study on Pharmacokinetic Profiles of Chicken IgY to Horse IgG in Rabbits

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Veröffentlicht: Jan 29, 2018
DOI: https://doi.org/10.12681/jhvms.15524
ZHAOXIANG ZHOU
State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science
JIAN WANG
College of Biological Science and Engineering, Shaanxi University of Technology
SONG GAO
College of Veterinary Medicine, Northwest A&F University
HAO REN
College of Veterinary Medicine, Northwest A&F University
WENYAN XIE
College of Veterinary Medicine, Northwest A&F University
DIRAVIYAM THIRUMALAI
School of Chemical and Biotechnology, SASTRA University,
XIAOYING ZHANG
State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science; College of Veterinary Medicine, Northwest A&F University
Abstract

Chicken IgY antibody has been extensively reported for various applications as an alternative to mammalian IgG. To evaluated the pharmacokinetics profile of chicken IgY in comparison with horse IgG. Chicken IgY antibody was prepared by immunizing the white leghorn chicken with tetanus toxoid (TT) and then extracted anti-TT-IgY from immune egg yolks by PEG-6000 extraction. The titer of anti-TT-IgY was determined by ELISA in order to select the hyper immune eggs for further extraction. Rabbits were injected with 300 μg/kg of Chicken IgY and horse IgG by intravenous (i.v.) and intramuscular (i.m.) administrations. Then, the concentrations of IgY and IgG in rabbit serum were determined using indirect ELISA. Pharmacokinetic parameters were estimated using non-compartmental analysis. IgY can reach higher concentration (Cmax= 4.54 mg/L after i.m. injection) within shorter time (Tmax= 0.12 h after i.m. injection) than IgG (Cmax= 3.99 ng/mL after i.m. injection; Tmax=0.11 h after i.m. injection), while the IgY lifespan (T1/2=26.98 h and 31.98 h after i.v. and i.m. administration, respectively) in the body was comparable with IgG (T1/2=27.94 h and 29.58 h after i.v. and i.m. administration, respectively). IgY might be a promising choice as an alternative to mammalian sourced antibodies.

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