A Review on Rabbit Hemorrhagic Disease with a Special Reference to Egyptian Situation

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DOI: https://doi.org/10.12681/jhvms.25065
WAFAA A ABD EL-GHANY
Poultry Diseases Department, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt
Abstract

Rabbit hemorrhagic disease (RHD) is considered as one of the most important viral diseases that affects and threatens rabbit’s flocks. This disease has affected rabbits since mid-1980. Two epidemics of RHD had been discovered; the first was in mid-1980 and known as classical RHD virus (RHDV), while the second was in 2011 and described as variant virus (RHDVb/RHDV2). Domestic and wild rabbits are susceptible to RHD. All ages can be affected, but adults are more susceptible to young kitten. RHD is presented in three forms; per-acute, acute and subacute or chronic form. Mortality rate is usually high especially in per-acute and acute stages and it is associated with disseminated intravascular coagulopathy and necrotic hepatitis. The main lesions have been observed in the liver, lungs and spleen. Diagnosis of RHD is based on the clinical picture and detection of RHDV or specific antibodies. The prevention and control strategies depend mainly on using of preventive inactivated vaccine together with adoptionof hygienic measures. However, there is no specific treatment of RHDV infection. So, this review article puts a spot light on RHD regarding the epidemiology, the clinical and laboratory diagnosis as well as the prevention and control strategies with a special reference to Egyptian situation.

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Literaturhinweise
Abd El-Ghafar SK, Fatma A, Aly M, Mahmoud AZ (2000) Pathological studies on the rabbit viral hemorrhagic disease. Assiut Vet Med J 43:251-274.
Abd El-Lateff AA (2006) Clinicopathological studies on rabbit hemorrhagic disease vaccines. (Ph.D. Thesis), Fac Vet Med, Cairo Univ, Egypt.
Abd El-Moaty DAM, El-Bagoury GF, El-Zeedy SAR, Salman OGA (2014) Egyptian non-hemagglutinating isolates of rabbit hemorrhagic disease virus can change to variable HA Profile. Benha Vet Med J 26: 71-83.
Abd El-Motelib TY (1993): Role of hyperimmune serum in protection against viral haemorrhagic disease of rabbits. Assiut Vet Med J, 28 (56): 297-307.
Abd El-Motelib TY, Abd El-Gawad AM, Azzaz HH (1998) Viral haemorrhagic disease of rabbit: Comparative study between the immune response of local and imported vaccine. Assiut Vet Med J 40 (79):150-156.
Abrantes J, van der Loo W, Le Pendu J, Esteves PJ (2012) Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): A review. Vet Res 43(1): 12.
Ahmad ST, El-Samadony HA, Mahgoub KM (2011) Immunological and virological studies on rabbit hemorrhagic disease virus. Global Vet 7: 545-556.
Alboghdady MA, Alashry MK (2010) The demand for meat in Egypt: An almost ideal estimation. Afr J Agric Resour Econ 4(1): 70-81.
Alda F, Gaitero T, Suarez M, Merchan T, Rocha G, Doadrio I (2010) Evolutionary history and molecular epidemiology of rabbit haemorrhagic disease virus in the Iberian Peninsula and Western Europe. BMC Evol. Biol 10(1): 347.
Alonso C, Oviedo JM, Martin-Alonso JM, Diaz E, Boga JA, Parra F (1998) Programmed cell death in the pathogenesis of rabbit hemorrhagic disease. Arch Virol 143(2): 321-332.
Arguello Villares JL (1991) Viral haemorrhagic disease of rabbits: vaccination and immune response. Rev Sci Tech 10: 471-480.
Asgari S, Hardy JR, Sinclair RG, Cooke BD (1998) Field evidence for mechanical transmission of rabbit haemorrhagic disease virus (RHDV) by flies (Diptera: Calliphoridae) among wild rabbits in Australia. Virus Res 54(2): 123-132.
Awad NF, Kotb GK (2018) Genetic characterization of rabbit hemorrhagic disease virus from naturally infected rabbits in Sharkia governorate, Egypt. J Virol Sci 3: 10-19.
Barcena J, Morales M, Vazquez B, Boga JA, Parra F, Lucientes J, Pages-Mante A, Sanchez-Vizcaino JM, Blasco R, Torres JM (2000) Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus. J Virol 74:1114-1123.
Belz K (2004) Rabbit hemorrhagic disease. Seminars in Avian and Exotic Pet Medicine, 13(2): 100-104.
Berninger ML, House C (1995) Serologic comparison of four isolates of rabbit hemorrhagic disease virus. Vet Microbiol 47 (1–2): 157-165.
Bertagnoli S, Gelfi J, Le Gall G, Boilletot E, Vautherot JF, Rasschaert D, Laurent S, Petit F, Boucraut-Baralon C, Milon A (1996b) Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein. J Virol 70: 5061-5066.
Bertagnoli S, Gelfi J, Petit F, Vautherot JF, Rasschaert D, Laurent S, Le Gall G, Boilletot E, Chantal J, Boucraut-Baralon C (1996a) Protection of rabbits against rabbit viral haemorrhagic disease with a vaccinia-RHDV recombinant virus. Vaccine 14: 506-510.
Broja G, Larias OMD (1990) Determination de la viabilidad del virus de la EHV cen alfalfa, alimento balanceado commercial costales paraalimentoy ratas. (Thesis). Fac Vet Med, Unam, Mexico.
Cabezas S, Calvete C, Moreno S (2006) Vaccination success and body condition in the European wild rabbit: applications for conservation strategies. J Wild Manage 70: 1125-1131.
Campagnolo ER, Ernst MJ, Berninger ML, Gregg DA, Shumaker TJ, Boghossian AM (2003) Outbreak of rabbit hemorrhagic disease in domestic lagomorphs. J Am Vet Med Assoc 223(8): 1151-1128.
Cancellotti FM, Renzi M (1991) Epidemiology and current situation of viral haemorrhagic disease of rabbits and the European brown hare syndrome in Italy. Re Sci Tech 10: 409-422.
Capucci L, Scicluna MT, Lavazza A (1991) Diagnosis of viral haemorrhagic disease of rabbits and the European brown hare syndrome. Rev Sci Tech 10: 347-370.
Capucci L, Fallacara F, Grazioli S, Lavazza A, Pacciarimi ML, Procchi E (1998) A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant. Virus Research, 58, 115-126.
CFSPH, Center for Food Security and Public Health, Iowa State University (2006). Rabbit Hemorrhagic Disease. Technical Factsheet. www.cfsph.iastate.edu
Chasey D (1997) Rabbit haemorrhagic disease: the new scourge of Oryctolagus cuniculus. Lab. Anim 31: 33-44.
Clouet RN, Blanchard D, Andre FG, Song B, Ganiere JP (1995). Detection of antibodies to RHDV: as immuno-blotting method using coated human erythrocyte membrane. J Vet Med 42 (4): 197-204.
Cooke BD (2002) Rabbit haemorrhagic disease: field epidemiology and the management of wild rabbit populations. Rev Sci Tech 21: 347-358.
Crisci E, Almanza H, Mena I, Cordoba L, Gomez-Casado E, Caston JR, Fraile L, Barcena J, Montoya M (2009) Chimeric calicivirus-like particles elicit protective anti-viral cytotoxic responses without adjuvant. Virology 387: 303-312.
Dalton KP, Nicieza I, Balseiro A, Muguerza MA, Rosell JM, Casais R, Parra F (2012) Variant rabbit hemorrhagic disease virus in young rabbits, Spain. Emer Infec Dis 18: 2009-2012.
Daoud AM, Khodeir MH, Abbass AM, Ibrahim SI (1998a) Preparation of a specific inactivated vaccine against RHDV. In: 4th Sci Conf, Fac Vet Med, Zagazig Univ, Egypt, p. 230-234.
Daoud AM, Khodeir MH, Abbass AM, Ibrahim SI, Gergis SM (1998b): Preliminary study for preparation of rabbit pasteurellosis and rabbit hemorrhagic disease virus combined vaccine. In: 4th Sci Conf, Fac Vet Med, Zagazig Univ, Egypt, p. 191-198.
Eid AAM, Ibraheem OK (2006) Sudden death among rabbits in Sharkia Province, Egypt. Zagazig Vet J 34: 108-119.
El-Bagoury GF, Abd El-Moaty DA, El-Zeedy SA, El-Nahas EM, Youssif AA (2014) Molecular identification of RHDV Egyptian strains based on the highly variable region of VP60 gene, Benha Vet Med J 26:84-100.
Eleraky NZ, Potgieter LN, Kennedy MA (2002) Virucidal efficacy of four new disinfectants. J Am Anim Hosp Assoc. 38(3): 231-234.
El Mehdaoui S, Touze A, Laurent S, Sizaret P-Y, Rasschaert D, Coursaget P (2000) Gene transfer using recombinant rabbit hemorrhagic disease virus capsids with genetically modified and encapsidation capacity by addition of packaging sequences from the l1 or l2 protein of human papillomavirus type 16. J Virol 74: 10332-10340.
El-Mongy FA (1998) Studies on viral hemorrhagic disease of rabbits (Ph.D. Thesis), Fac Vet Med, Zagazig Univ, Egypt.
El-Sissi FA, Gafer JA (2008) Preliminary diagnosis of non haemagglutinating strain of rabbit hemorrhagic disease virus in Egypt. Egypt J Comp Pathol Clin Pathol 21:161-175.
El-Zanaty K (1994) Some investigation on rabbit viral haemorrhagic disease in Upper Egypt. Assiut Vet Med J 30(60): 293-305.
Embury-Hyatt C, Postey R, Hisanaga T, Lynn B, Hooper-McGrevy K, McIntyre L, Millar K, Pasick J (2012) The first reported case of rabbit hemorrhagic disease in Canada. Canad Vet J 53: 998-1002.
Erfan AM, Shalaby AG (2020) Genotyping of rabbit hemorrhagic disease virus detected in diseased rabbits in Egyptian provinces by VP60 sequencing, Vet World 13(6): 1098-1107.
Ewees GAS (2007) Further studies on hemorrhagic viral disease in rabbit. (Ph.D. Thesis), Fac Vet Med, Cairo Univ, Egypt.
Fahmy HA, Arafa A, Mahmoud AH (2010) Molecular diagnosis of rabbit hemorrhagic disease virus (RHDV). Egypt J Comp Pathol Clin Pathophysiol 23: 85-101.
Farnos O, Boue O, Parra F, Martin-Alonso JM, Valdes O, Joglar M, Navea L, Naranjo P, Lleonart R (2005) High-level expression and immunogenicproperties of the recombinant rabbit hemorrhagic disease virus VP60 capsid protein obtained in Pichia pastoris. J Biotechnol 117:215-224.
Farnos O, Rodriguez M, Chiong M, Parra F, Boue O, Lorenzo N, Colas M, Lleonart R (2006) The recombinant rabbit hemorrhagic disease virus VP60 protein obtained from Pichia pastoris induces a strong humoral and cell mediated immune response following intranasal immunization in mice. Vet Microbiol 114: 187-195.FAO, Food and Agriculture Organization of the United Nations Database (2019) Available from:
http://www.faostat. fao.org. Retrieved on 05-03-2019.
Ferreira PG, Costa ESA, Monteiro E, Oliveira MJ, Aguas AP (2006) Liver enzymes and ultrastructure in rabbit haemorrhagic disease (RHD). Vet Res Commun 30: 393-401.
Forrester NL, Abubakr MI, Abu Elzein EM, al Afaleq AI, Housawi FM, Moss SR, Turner SL, Gould EA (2006) Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia? Virology 344:277-282.
Forrester NL, Moss SR, Turner SL, Schirrmeier H, Gould EA (2008) Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiology. Virology 376: 390-396.
Ghanem IA, Ismail AN (1992) Occurrence of rabbit hemorrhagic disease in Sharkia province. Zag Vet Med J 20(4): 491-502.
Gould AR, Kattenbelt JA, Lenghaus C, Morrissy C, Chamberlain T, Collins BJ, Westbury HA (1997) The complete nucleotide sequence of rabbit haemorrhagic disease virus (Czech strain V351): use of the polymerase chain reaction to detect replication in Australian vertebrates and analysis of viral population sequence variation. Virus Res
: 7-17.
Gregg DA, House C, Meyer R, Berninger M (1991) Viral haemorrhagic disease of rabbits in Mexico: epidemiology and viral characterization. Rev Sci Tech 10: 435-451.
Guittre CI, Baginski G, Gall LE (1995) Detection of rabbit hemorrhagic disease virus isolates and sequence comparison of the N-terminus of the capsid protein gene by the polymerase chain reaction. Res Vet Sci 58: 128-132.
Hamed AM, Eid AAM, El-Bakrey RMM (2013) A review of rabbit diseases in Egypt. WARTAZOA 23 (4): 185-194.
Henning J, Meers J, Davies PR, Morris RS (2005) Survival of rabbit haemorrhagic disease virus (RHDV) in the environment. Epidemiol Infect 133: 719-730.
Huang HB (1991) Vaccination against and immune response to viral haemorrhagic disease of rabbits: a review of research in the People’s Republic of China. Rev Sci Tech, 10: 481-498.
Ibrahim IS, Abass AM, ElKholy AA, Safia TK, Hussein AZ (1999) Simultaneous infection with rabbit haemorrhagic disease virus and rabbit pasteurellosis in rabbit farms in Egypt. Alex J Vet Sci 15 (3): 567-578.
Ismail MM, Mohamed MH, ElSabagh IM, Al-Hammadi MA (2017) Emergence of new virulent rabbit hemorrhagic disease virus strains in Saudi Arabia. Trop Anim Health Prod 49: 295-301.
ITAVI Institut Technique de l’Aviculture (2019) Fiches de Biosécurité en Élevage de Lapins. Available online: https://www.itavi.asso.fr/content/fiches-de-biosecurite-en-elevage-de-lapins (accessed on 11 May 2019).
Khodeir MH, Daoud AM (2002). Preparation and evaluation of an inactivated cell culture rabbit hemorrhagic disease virus vaccine. SCOVM J 1: 75-94.
Kovalisk J (1998) Monitoring the spread of rabbit hemorrhagic disease virus as a new biological agent for control of wild European rabbits in Australia. J Wildl Dis 34(8): 421-428.
Lavazza A, Capucci (1996) Viral hemorrhagic disease of rabbits. In: Manual of Standards for Diagnostic Tests and Vaccines, 3rd Ed., Reichard, rd R. Paris, France, Office International des Epizooties, Chapter, 3:7-3.
Lavassa A, Capucci L (2008) How many caliciviruses are there in rabbits. A review on RHDV and correlated viruses. In: Lagomorph Biology: Evolution, Ecology and Conservation. Springer-Verlag Berlin Heidelberg 263-278.
Le Gall-Recule G, Zwingelstein F, Laurent S, de Boisseson C, Portejoie Y, Rasschaert D (2003) Phylogenetic analysis of rabbit haemorrhagic disease virus in France between 1993 and 2000, and the characterization of RHDV antigenic variants. Arch Virol 148(1): 65-81.
Le Gall-Recule G, Lavazza A, Marchandeau S, Bertagnoli S, Zwilgenstaein F, Cavadini P, Martinelli N, Lombardi G, Guerin JL, Lemaitre E, Décors A, Boucher S, Le Normand B, Capucci L (2013) Emergence of a new lago virus related to rabbit haemorrhagic disease virus. Vet Res 44(1): 81.
Liu SJ, Xue HP, Pu BQ, Qian NH (1984) A new viral disease in rabbits. Anim. Husbandry Vet Med 16 (6): 253- 255.
Marcato PS, Benazzi C, Vecchi G, Galeotti M., Salda LD, Sarli G, Lucidi P (1991) Clinical and pathological features of viral haemorrhagic disease of rabbits and the European brown hare syndrome. Rev Sci Tech Off Int Epizoot 10: 371-392.
Magouzi AF, Elsayed EA, Metwally AY (2019) Detection and characterization of rabbit hemorrhagic disease virus strains circulating in Egypt. Bulg J Vet Med 22(4): 409-418.
Marques RM, Costa ESA, Aguas AP, Teixeira L, Ferreira PG (2010) Early acute depletion of lymphocytes in calicivirus-infected adult rabbits. Vet Res Commun 34(8): 659-668.
Martin-Alonso JM, Castanon S, Alonso P, Parra F, Ordas R (2003) Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res 12: 127-130.
McColl KA, Morrissy CJ, Collins BJ, Westbury HA (2002) Persistence of rabbit haemorrhagic disease virus in decomposing rabbit carcases. Aust Vet J 80: 298-299.
McIntosh MT, Behan SC, Mohamed FM, Lu Z, Moran KE, Burrage TG, Neilan JG, Ward GB, Botti G, Capucci L, Metwally SA (2007) A pandemic strain of calicivirus threatens rabbit industries in the Americas. Virol J 4: 96-10.
Metwally AY, Madbouly HM (2005) Study on a new isolate of rabbit heamorrhagic disease virus. Bani-suef Vet Med J 15(2): 283-243.
Merchán T, Rocha G, Alda F, Silva E, Thompson G, Hidalgo de Trucios S, Pagès-Manté A (2011) Detection of rabbit haemorrhagic disease virus (RHDV) in nonspecific vertebrate hosts sympatric to the European wild rabbit (Oryctolagus cuniculus). Infect Genet Evol 11:1469-1474.
Meyers G, Wirblich C, Thiel HJ (1991) Rabbit hemorrhagic disease virus-molecular cloning and nucleotide sequencing of a calicivirus genome. Virology 184(2): 664-676.
Miao O, Qi R, Veldkamp L, Ijzer J, Kik ML, Zhu JM, Tang A, Dong D, Shi Y, Van Oers MM, Liu G, Pijlman GP (2019) Immunogenicity in rabbits of virus-like particles from a contemporary rabbit haemorrhagic disease virus Type 2 (GI.2/RHDV2/b) isolated in the Netherlands. Viruses 11(6): 553.
Mitro S, Krauss H. (1993). Rabbit hemorrhagic disease: a review with reference to its epizooitology. Europ J Epidemiol 9(1): 70-78.
Mohamed FO (2009). Clinic pathological studies on the effect of viral hemorrhagic disease (VHD) in rabbits (Master Thesis). Zagazig University, Egypt.
Morisse JP, Le Gall G, Boilletot E (1991) Hepatitis of viral origin in Leporidae: introduction and aetiological hypotheses. Rev Sci Tech 10:283-295.
Moss SR, Turner SL, Trout RC, White PJ, Hudson PJ, Desai A, Armesto M, Forrester NL, Gould EA (2002) Molecular epidemiology of rabbit haemorrhagic disease virus. J General Virol 83: 2461-2467.
Mostafa AA (2001) Characterization and pathogenicity of locally isolated virus of hemorrhagic disease in rabbits. (Ph.D. Thesis), Fac Vet Med, Beni-Suef Univ, Egypt.
Moussa A, Chasey D, Lavazza A, Capucci L, Smid B, Meyers G, Rossi C, Thiel HJ, Vlasak R, Ronsholt L, Nowotny N, McCullough K, Gavier-Widenm D (1992) Haemorrhagic disease of lagomorphs: Evidence for a calicivirus. Vet Microbiol 33(1-4): 375-381.
Muller A, Freitas J, Silva E, Le Gall-Reculé G, Zwingelstein F, Abrantes J, Esteves PJ, Alves PC, van der Loo W, Kolodziejek J, Nowotny N, Thompson G. (2009) Evolution of rabbit haemorrhagic disease virus (RHDV) in the European rabbit (Oryctolagus cuniculus) from the Iberian Peninsula. Vet Microbiol 135: 368-373.
Nagesha HS, Wang LF, Hyatt AD, Morrissy CJ, Lenghaus C, Westbury HA (1995) Self-assembly, antigenicity, and immunogenicity of the rabbit haemorrhagic disease virus (Czechoslovakian strain V-351) capsid protein expressed in baculovirus. Arch Virol 140: 1095-1108.
Ohlinger VF, Haas B, Thiel HJ (1993) Rabbit haemorrhagc disease (RHD): Characterization of the causative calicivirus. Vet Res 24(2):103-116.
OIE Office of International Epizootics (2008) Terrestrial Manual. Viral hemorrhagic disease of rabbits. Chapter 2.6.2. P. 947-961.
OIE Office of International Epizootics (2010) Terrestrial Manual. Viral hemorrhagic disease of rabbits. 1-15.
OIE Office of International Epizootics (2012) Terrestrial Manual. Viral hemorrhagic disease of rabbits, Rabbit Calcivirus disease. Chapter 2.6.2 pp. 1–15.
OIE Office of International Epizootics (2018) Terrestrial Animal Health Code. 2018. Available online: http://www.oie.int/en/standard-setting/terrestrial-code/access-online/ (accessed on 19 May 2019).
Patton NM (1989) Viral hemorrhagic disease. A major new disease problem of rabbits. Rabbit Res 12: 64-67.
Park JH, Lee YS, Itakura C (1995) Pathogenesis of acute necrotic hepatitis in rabbit hemorrhagic disease. Lab Anim Sci 45(4): 445-449.
Peacey M, Wilson S, Baird MA, Ward VK (2007) Versatile RHDV virus-like particles: incorporation of antigens by genetic modification and chemical conjugation. Biotechnol Bioeng 98: 968-977.
Peacey M, Wilson S, Perret R, Ronchese F, Ward VK, Young V, Young SL, Baird MA (2008) Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response. Vaccine 26: 5334-5337.
Peshev R, Christova L (2003) The efficacy of a bivalent vaccine against pasteurellosis and rabbit haemorrhagic disease virus. Vet Res Commun 27: 433-444.
Plana-Duran J, Bastons M, Rodriguez MJ, Climent I, Cortes E, Vela C, Casal I (1996) Oral immunization of rabbits with VP60 particles confers protection against rabbit hemorrhagic disease. Arch Virol 141:1423-1436.
Plassiart G, Guelfi JF, Ganiere JP, Wang B, Andre-Fontaine G, Wyers M (1992) Hematological parameters and visceral lesions relationships in rabbit viral hemorrhagic disease. J Vet Med (B) 39: 443-53.
Pu BQ, Quian NH, Cui S (1985) Micro HA and HI tests for the detection of antibody titres to so-called ‘haemorrhagic pneumonia’ in rabbits [in Chinese]. Chin J Vet Med 11: 16-17.
Ramiro-Ibáñez F, Martín-Alonso JM, García Palencia P, Parra F, Alonso C (1999) Macrophage tropism of rabbit hemorrhagic disease virus is associated with vascular pathology. Virus Res 60: 21-28.
Ruvoen-Clouet N, Ganiere JP, Andre-Fontaine G, Blanchard D, Le Pendu J (2000) Binding of rabbit hemorrhagic disease virus to antigens of the ABH histo-blood group family. J Virol 74: 11950-11954.
Sahar TA, Hanaa AE, Khalid MM (2011) Immunological and virological studies on rabbit hemorrhagic disease virus. Global Vet 7 (6): 545-556.
Salem B, El-Ballal SS (1992) The occurrence of rabbit hemorrhagic disease (RHVD) in Egypt. Assiut Vet Med J 27(53): 295-304.
Salem B, El-Zanaty K (1992) Tissue-derived inactivated vaccine against rabbit viral haemorrhagic disease. In: Proc 5th Sci Conf, Fac Vet Med, Assiut Univ, Egypt.
Schirrmeier H, Reimann I, Kollner B, Granzow H (1999) Pathogenic, antigenic and molecular properties of rabbit haemorrhagic disease virus (RHDV) isolated from vaccinated rabbits: detection and characterization of antigenic variants. Arch Virol 144: 719-735.
Sharawi SSA (1992) Studies on the virus causing haemorrhagic septicemia in rabbits (Master Thesis). Fac Vet Med, Zagazig Univ, Egypt.
Smid B, Valicek L, Rodak L, Stepanek J, Jurak E (1991). Rabbit haemorrhagic disease: an investigation of some properties of the virus and evaluation of an inactivated vaccine. Vet Microbiol 26: 77-85.
Soliman MA, Abdel Rahman MA, Samy MM, Mehana O, Nasef SA (2016) Molecular, clinical and pathological studies on viral rabbit hemorrhagic disease. Alex J Vet Sci 48: 20-26.
Trzeciak-Ryczek A, Tokarz-Deptuła B, Deptuła W (2015) The importance of liver lesions and changes to biochemical and coagulation factors in the pathogenesis of RHD, Acta Biochimica Polonica 62: 169-171.
Ueda K, Park JH, Ochiai K, Itakura C (1992) Disseminated intravascular coagulation (DIC) in rabbit haemorrhagic disease. Jpn J Vet Res 40(4): 133-141.
Urakova N, Hall R, Strive T, Frese M (2019) Restricted host specificity of rabbit hemorrhagic disease virus supported by challenge experiments in immune-compromised mice (Mus musculus). J Wildl Dis 55(1):218-222.
Wang X, Xu F, Liu J, Gao B, Liu Y, Zhai Y, Ma J, Zhang K, Baker TS, Schulten K, Zheng D, Pang H, Sun F (2013) Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. PLoS Pathogens. 9(1): e1003132.
Xu WY (1991) Viral hemorrhagic disease of rabbits in the people’s republic of China: Epidemiology and virus characterization. Rev Sci Tech 10(2): 393-408.
Xu ZJ, Chen WX (1989). Viral haemorrhagic disease in rabbits: a review. Vet Res Commun 13: 205-212.
Win SJ, Ward VK, Dunbar PR, Young SL, Baird MA (2011) Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunol Cell Biol 89: 681-688.
Young SL, Wilson M, Wilson S, Beagley KW, Ward V, Baird MA (2006) Transcutaneous vaccination with virus-like particles. Vaccine 24:5406-5412.