Rapid Resolution of Megaesophagus by Low-dose Levothyroxine in a Hypothyroid dog with Mitral Valve Degeneration

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Veröffentlicht: Ιουλ 10, 2022
DOI: https://doi.org/10.12681/jhvms.26553
Dohee Lee
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Taesik Yun
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Yoonhoi Koo
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Yeon Chae
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Byeong-Teck Kang
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Mhan-Pyo Yang
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Hakhyun Kim
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Republic of Korea
https://orcid.org/0000-0002-8882-2329
Abstract

A 14-year-old intact female Maltese dog weighting 4.84kg was presented with acute regurgitation. At presentation, the dog was diagnosed with megaesophagus and primary hypothyroidism based on the radiography and thyroid-stimulating hormone stimulation test, respectively. Treatment was initiated with oral low-dose levothyroxine (0.0025 mg/kg b.w., orally, SID) considering underlying myxomatous mitral valve disease. Ten days after the management, the clinical and radiographic signs of megaesophagus were completely resolved. The dog was managed by levothyroxine administration with a gradual increase of the dose along with the monitoring of serum thyroxine concentrations since the dog was diagnosed with hypothyroidism. At 10 months after presentation, the dog continued to do well clinically. This is first case report describing rapid resolution of generalized megaesophagus after low-dose levothyroxine administration considering underlying cardiac disease in a hypothyroid dog.

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Literaturhinweise
Boretti FS, Sieber-Ruckstuhl NS, Wenger-Riggenbach B, Gerber B, Lutz H, Hofmann-Lehmann R, Reusch CE (2009) Comparison of 2 doses of recombinant human thyrotropin for thyroid function testing in healthy and suspected hypothyroid dogs. J Vet Intern Med 23:856–861.
Boswood A, Gordon SG, Häggström J, Wess G, Stepien RL, Oyama MA, Keene BW, Bonagura J, MacDonald KA, Patteson M, Smith S, Fox PR, Sanderson K, Woolley R, Szatmári V, Menaut P, Church WM, O'Sullivan ML, Jaudon JP, Kresken JG, Rush J, Barrett KA, Rosenthal SL, Saunders AB, Ljungvall I, Deinert M, Bomassi E, Estrada AH, Fernandez Del Palacio MJ, Moise NS, Abbott JA, Fujii Y, Spier A, Luethy MW, Santilli RA, Uechi M, Tidholm A, Schummer C, Watson P (2018) Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. J Vet Intern Med 32:72–85.
Busch C (1980) Structure of the esophagus of the dog. Acta Anat (Basel) 107:339–360.
Fracassi F, Tamborini A (2011) Reversible megaoesophagus associated with primary hypothyroidism in a dog. Vet Rec 168:329b.
Gaynor AR, Shofer FS, Washabau RJ (1997) Risk factors for acquired megaesophagus in dogs. J Am Vet Med Assoc 211:1406–1412.
Huber E, Armbrust W, Forster JL, Ribière T, Grosclaude P (2001) Resolution of megaesophagus after treatment of concurrent hypothyroidism in a dog. Schweiz Arch Tierheilkd 143:512–514.
Jaggy A, Oliver JE, Ferguson DC, Mahaffey EA, Glaus T Jr (1994) Neurological manifestations of hypothyroidism: a retrospective study of 29 dogs. J Vet Intern Med 8:328–336.
Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG, Smith SA, Daniels GH, Cohen HD (2000) American thyroid association guidelines for detection of thyroid dysfunction. Arch Intern Med 160:1573–5.
Manning K, Birkenheuer AJ, Briley J, Montgomery SA, Harris J, Vanone SL, Gookin JL (2016) Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus. J Vet Intern Med 30:1715–1719.
McBrearty AR, Ramsey IK, Courcier EA, Mellor DJ, Bell R (2011) Clinical factors associated with death before discharge and overall survival time in dogs with generalized megaesophagus. J Am Vet Med Assoc 238:1622–1628.
Mooney CT. Canine hypothyroidism: a review of aetiology and diagnosis (2011) N Z Vet J 59:105–114.
Paik J, Kang JH, Chang D, Yang MP (2016) Cardiogenic Pulmonary Edema in a Dog Following Initiation of Therapy for Concurrent Hypoadrenocorticism and Hypothyroidism. J Am Anim Hosp Assoc 52:378–384.
Panciera DL (2001) Conditions associated with canine hypothyroidism. Vet Clin North Am Small Anim Pract 31:935–950.
Phillips DE, Harkin KR (2003) Hypothyroidism and myocardial failure in two Great Danes. J Am Anim Hosp Assoc 39:133–137.
Platt SR (2002) Neuromuscular complications in endocrine and metabolic disorders. Vet Clin North Am Small Anim Pract 32:125–146.
Pollard JD (2005) Neuropathy in disease of the thyroid and pituitary glands. In: Peripheral neuropathy. 4th ed, Elsevier Saunders, Philadelphia, USA: pp 2039–2049.
Quattrini A, Nemni R, Marchettini P, Fazio R, Iannaccone S, Corbo M, Canal N (1993) Effect of hypothyroidism on rat peripheral nervous system. Neuroreport 4:499–502.
Rossmeisl JH, Duncan RB, Inzana KD, Panciera DL, Shelton GD (2009) Longitudinal study of the effects of chronic hypothyroidism on skeletal muscle in dogs. Am J Vet Res 70:879–889.
Scott-Moncrieff JC (2015) Hypothyroidism. In: Canine and feline endocrinology. 4th ed, Elsevier, St.Louis, USA: pp 2015:77–135.
Sidenius P, Nagel P, Larsen JR, Boye N, Laurberg P (1987) Axonal transport of slow component in a sciatic nerves of hypo- and hyperthyroid rats. J Nuerochem 49:1790–1795.
Sindoni A, Rodolico C, Pappalardo MA, Portaro S, Benvenga S (2016) Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature. Rev Endocr Metab Disord 17:499–519.
Utsugi S, Saito M, Shelton GD (2014) Resolution of polyneuropathy in a hypothyroid dog following thyroid supplementation. J Am Anim Hosp Assoc 50:345–349.