Effect of Butorphanol with and without Medetomidine on Intraocular Pressure in Cats


Veröffentlicht: Οκτ 16, 2023
N Mohammadi
https://orcid.org/0000-0002-0082-5534
LE Yanmaz
https://orcid.org/0000-0001-5890-8271
Abstract
This study aimed to determine the effects of intramuscular administration of butorphanol with and without medetomidine on intraocular pressure (IOP) in cats. Sixteen clinically normal cats were used. Cats were randomly received two-treatment regimen. The first regimen was 0.2mg/kg butorphanol, and the second regimen was a mixture of 0.1mg/kg butorphanol and 0.05mg/kg medetomidine. IOP values were recorded before treatment (T0) and following the treatment at 10 (T10), 20 (T20), 30 (T30), and 40 min (T40) in both groups. Administration of butorphanol with and without medetomidine did not cause a statistically significant change in IOP values. The IOP did not change over time (p = 0.41). The mean values of IOP in butorphanol, and butorphanol-medetomidine groups were 20.00 ± 2.29 and 20.38 ± 2.35 mm Hg, respectively. In conclusion, intramuscular administration of butorphanol with or without medetomidine had no significant effect on IOP in cats.
Article Details
  • Rubrik
  • Research Articles
Downloads
Keine Nutzungsdaten vorhanden.
Literaturhinweise
Binnawi KH, Elzubeir H, Osman E, Abdu M, Abdu M (2019) Central
corneal thickness measurement using ultrasonic pachymeter, optical
coherence tomography, and TMS-5 topographer. Oman J Ophthalmol
(1):15.
Bron AM, Creuzot-Garcher C, Goudeau-Boutillon S, d’Athis P (1999)
Falsely elevated intraocular pressure due to increased central corneal
thickness. Graefes Arch Clin Exp Ophthalmol 237(3):220-224.
Chatterjee A, Shah S, Bessant DA, Naroo SA, Doyle SJ (1997) Reduc
tion in intraocular pressure after excimer laser photorefractive ker
atectomy: correlation with pretreatment myopia. Ophthalmology
(3):355-359.
Douet JY, Regnier A, Dongay A, Jugant S, Jourdan G, Concordet D
(2018) Effect of sedation with butorphanol on variables pertaining to
the ophthalmic examination in dogs. Vet Ophthalmol 21(5):452-458.
Duncalf D (1975) Anesthesia and intraocular pressure. Bull N Y Acad
Med 51(3):374. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD,
Lameh J (2006) Pharmacological profiles of opioid ligands at kappa
opioid receptors. BMC pharmacol 6(1):1-7.
Gordon MO, Beiser JA, Brandt JD, et al (2002) The Ocular Hypertension
Treatment Study: baseline factors that predict the onset of primary
open-angle glaucoma. Arch Ophthalmol 120(6):714-720.
Kniestedt C, Lin S, Choe J, Bostrom A, Nee M, Stamper RL (2005) Clin
ical comparison of contour and applanation tonometry and their rela
tionship to pachymetry. Arch Ophthalmol 123(11):1532-1537.
Lamont LA, Bulmer BJ, Grimm KA, Tranquilli WJ, Sisson DD (2001)
Cardiopulmonary evaluation of the use of medetomidine hydrochlo
ride in cats. Am J Vet Med Res 62(11):1745-1762.
Malmasi A, Selk Ghaffari M (2016) Lack of effects of intramuscular me
detomidine on intraocular pressure in clinically normal cats. J Feline
Med Surg 18(4):315-317.
Mrazova M, Rauser P, Burova J, Georgiou M, Fichtel T (2018) Influence
of medetomidine, acepromazine, fentanyl and butorphanol on intraoc
ular pressure and pupil size in healthy dogs. Vet Med 63(9):413-419.
Murphy DF (1985). Anesthesia and intraocular pressure. Anesth Analg
(5):520-530.
Ossipov MH, Harris S, Lloyd P, Messineo E, Lin B-S, Bagley J (1990)
Antinociceptive interaction between opioids and medetomidine sys
temic additivity and spinal synergy. Anesthesiology 73(6):1227-1235.
Pierce-Tomlin T, Shaughnessy MR, Hofmeister EH (2020) A systematic
review of the effects of injectable sedative and anesthetic drugs and
inhalant anesthetics on intraocular pressure in the dog. Vet Anaesth
Analg 47(2):145-151.
Rauser P, Pfeifr J, Proks P, Stehlík L (2012) Effect of medetomidine‐butor
phanol and dexmedetomidine‐butorphanol combinations on intraocu
lar pressure in healthy dogs. Vet Anaesth Analg 39(3):301-305.
Reader RC, Barton BA, Abelson AL (2019) Comparison of two intramus
cular sedation protocols on sedation, recovery and ease of venipunc
ture for cats undergoing blood donation. J Feline Med Surg 21(2):95
Robertson SA, Gogolski SM, Pascoe P, Shafford HL, Sager J, Griffen
hagen GM (2018) AAFP feline anesthesia guidelines. J Feline Med
Surg 20(7):602-634.
Selmi AL, Mendes GM, Lins BT, Figueiredo JP, Barbudo-Selmi GR
(2003) Evaluation of the sedative and cardiorespiratory effects of
dexmedetomidine, dexmedetomidine-butorphanol, and dexmedeto
midine-ketamine in cats. J Am Vet Med Assoc 222(1):37-41.
Simon B, Steagall P (2017) The present and future of opioid analgesics in
small animal practice. J Vet Pharmacol Ther 40(4):315-326.
Telle MR, Chen N, Shinsako D, Kiland JA, Oikawa K, Møller Trane R,
McLellan GJ (2019) Relationship between corneal sensitivity, cor
neal thickness, corneal diameter, and intraocular pressure in normal
cats and cats with congenital glaucoma. Vet Ophthalmol 22(1):4-12.
Yanmaz LE, Dogan E, Okur S, Okumus Z, Ersoz U (2016) Comparison of
the effects of intranasal and intramuscular administrations of zolaze
pam-tiletamine combination on intraocular pressure in cats. Vet Oph
thalmol 19:115-118.