Neuroacting drugs and its pharmacological response in relation to different stress status: A review


YJ MOUSA
Abstract

This article intended to review many methods and types of stressors in the previous works of literaturethat describe the role of these stressors to induce modifications and alterations in the pharmacological response of the drugs acting on the nervous system (neuroacting drugs) in human and animal models. The current review focus on the different methods for inducing stress status which categorized as chemical, physical and miscellaneous stressors that affect on the well-known pharmacological response of the neuroacting drugs and by which mechanism can the stressor induce a modification in the drug target response with mentioning the findings related to changes in the pharmcologiacal response of the neuroacting drugs in previous literature. In conclusion, most studies suggest an alteration of the pharmacological response of neuroacting drugs, commonly by potentiating their efficacy and subsequent toxicity, due to different stressful methods, which may be obligated to the direct and indirect receptor modification (pharmacodynamic interaction) in addition to the direct pharmacokinetic influence on the essential parameters of absorption, distribution, metabolism, and excretion of the neuroacting drugs.

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Literaturhinweise
Abdel Baky NA, Ali AA (2009) Diazepam potentiates the protective effect of simvastatin against psychological stress-enhancement of doxorubicin cardiomyopathy. Intern J Acad Res 1:59-67.
Achuba FI, Peretiemo-Clarke BO, Okolie TC (2005) Oxidative stress in the brain of rabbits with petroleum-induced hypoglycaemia. Biol Lett 42:33-39.
Ahmed LI (2010) Neurobehavioral and biochemical studies of hydrogen peroxide induced oxidative stress in chicks. MSc Thesis, University of Dohok, Dohok, Iraq.
Akaishi T, Nakazawa K, Sato K, Saito H, Ohno Y, Ito Y (2004) Hydrogen peroxide modulates whole cell Ca+2 currents through L-type channels in cultured rat dentate granule cells. Neurosci Lett 356:25-28.
Altintas L, Essiz D, Eraslan G, Ince S, Arslanbas E (2010) Prophylactic effect of N-acetylcysteine against sodium fluoride-induced blood oxidative stress in mice. Food Chem Toxicol 48:2838-2841.
Baigi MG, Brault L, Neguesque A, Beley M, El Hilali R, Gauzere F, Bagrel D (2008) Apoptosis/necrosis switch in two different cancer cell lines: Influence of benzoquinone-and hydrogen peroxide-induced oxidative stress intensity, and glutathione. Toxicol in Vitro 22:1547-1554.
Barbaccia ML, Roscetti G, Bolacchi F, Concas A, Mostallino MC, Purdy RH, Biggio G (1996) Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil. Pharmacol Biochem Behav 54:205-210.
Castro AA, Casagrande TS, Moretti M, Constantino L, Petronilho F, Guerra GCB, Calo G, Guerrini R, Dal-Pizzol F, Quevedo J, Gavioli EC (2009) Lithium attenuates behavioral and biochemical effects of neuropeptide S in mice. Peptides 30:1914-1920.
Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Sci 262:689-695.
Crawford DR, Wang Y, Schools GP, Kochheiser J, Davies KJA (1997) Down-regulation of mammalian mitochondrial RNAs during oxidative stress. Free Radical Biol Med 22:551-559.
Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A (2006) Biomarkers of oxidative damage in human disease. Clin Chem 52:601-623.
Daneman R, Prat A (2015) The blood-brain barrier. Cold Spring Harb Perspect Biol 7:a020412.
Del Rio D, Stewart AJ, Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nut Met Cardiovas Dis 15:316-328.
Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: Mechanisms involved in metal-induced oxidative damage. Curr Topics Med Chem 1:529-539.
Fatokun AA, Stone TW, Smith RA (2007) Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: Mechanism and protection by adenosine receptor ligands. Brain Res 1132:193-202.
Garcia DA, Marin RH, Perillo MA (2002) Stress-induced decrement in the plasticity of the physical properties of chick brain membrane. Mol Mem Biol 19:221-230.
Gunn BG, Cunningham L, Mitchell SG, Swinny JD, Lambert JJ, Belelli D (2015) GABAA receptor-acting neurosteroids: A role in the development and regulation of the stress response. Front Neuroendocrinol 36:28-48.
Hegarty AA, Vogel WH (1995) The effect of acute and chronic diazepam treatment on stress-induced changes in cortical dopamine in rats. Pharmacol Biochem Behav 52:771-778.
Hussain S, Slikker WJr, Ali SF (1995) Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain. Int J Dev Neurosci 13:811-817.
Jemai H, Messaoudi I, Chaouch A, Kerkeni A (2007) Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. J Trace Elem Biol 21:269-273.
Jie F, Yi, G, Yang W, Yang M, Gao S, Lv J., Li B (2018) Stress in regulation of GABA amygdala system and relevance to neuropsychiatric diseases. Front Neurosci 12: 562.
Kalman BA, Kim PJ, Cole MA, Chi MS, Spencer RL (1997) Diazepam attenuation of restraint stress-induced corticosterone levels is enhanced by prior exposure to repeated restraint. Psychoneuroendocrinol 22:349-360.
Kar SK, Choudhury I (2016) An empirical review on oxidative stress markers and their relevance in obsessive-compulsive disorder. Int J Nut Pharmacol Neurol Dis 6:139-145.
Kasahara E, Sekiyama A, Hori M, Kuratsune D, Fujisawa N, Chida D, Hiramoto H, Li J, Okamura H, Inoue M, Kitagawa S (2015) Stress-Induced Glucocorticoid Release Upregulates Uncoupling Protein-2 Expression and Enhances Resistance to Endotoxin-Induced Lethality. Neuroimmunomodul 22:279-292.
Khokhar JY, Tyndale RF (2011) Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacol 36:692-700.
Langeveld CH, Schepens E, Stoof JC, Bast A, Benjamin D (1995) Differential sensitivity to hydrogen peroxide of dopaminergic and noradrenergic neurotransmission in rat brain slices. Free Radical Biol Med 19:209-217.
Lee KJ, Jeong HG (2007) Protective effect of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol Lett 173:80-87.
Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interven Aging 13:757-772.
Lochhead JJ, McCaffrey G, Quigley CE, Finch J, DeMarco KM, Nametz N, Davis TP (2010) Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J Cerebral Blood Flow Met 30:1625-1636.
Lopez J, Gonzalez ME, Lorigados L, Morales L, Riveron G, Bauza JY (2007) Oxidative stress markers in surgically treated patients with refractory epilepsy. Clin Biochem 40:292-298.
Mansour SA, Mossa A-TH (2009) Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc. Pest Biochem Physiol 93:34-39.
Marin RH, Arce A (1996) Benzodiazepine receptors increase induced by stress and maze-learning performance in chick forebrain. Pharmacol Biochem Behav 53:581-584.
Marnett LJ (1999) Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 424:83-95.
Marrocco I, Altieri F, Peluso I (2017) Measurement and clinical significance of biomarkers of oxidative stress in Humans. Oxid Med Cell Longev 2017:6501046.
Mehta A, Verma RS, Srivastava N (2009) Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver. Pest Biochem Physiol 94:55-59.
Mendes R, Cardoso C, Pestana C (2009) Measurement of malondialdehyde in fish: A comparison study between HPLC methods and the traditional spectrophotometric test. Food Chem 112:1038-1045.
Miller L, Thompson M, Greenblatt D, Deutsch S, Shader R, Paul S (1987) Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice. Brain Res 414:395-400.
Mohammad FK (1994) Effect of cadmium on detomidine-ketamine anesthesia in mice. Iraqi J Vet Sci 7:137-141.
Mohammad FK, Al-Baggou’ BKh and Tawfeek FKh (2000) Interaction of cadmium with xylazine in mice: locomotor activity and plasma glucose concentration. Iraqi J Vet Sci 13:23-33.
Mohammad FK, Tawfeek FKh, Hassan AA (1999) Pentobarbital anesthesia in rats treated with hydrogen peroxide: effect of vitamin E. Iraqi J Vet Sci 12:203-210.
Moreira JCF, Dal-Pizzol F, Bonatto F, Silva EG, Flores DG, Picada JN, Roesler R, Henriques JAP (2003) Oxidative damage in brains of mice treated with apomorphine and its oxidized derivative. Brain Res 992:246-251.
Motohashi N, Okamoto Y, Osada M, Yamawaki S (1993) Acute swim stress increases benzodiazepine receptors, but not GABAA or GABAB receptors, in the rat cerebral cortex. Neurochem Intern 23:327-330.
Mousa YJ (2012) Pharmacological Response to Some Sedatives and Analgesics in Chicks Stressed with Hydrogen Peroxide. PhD Dissertation, Mosul University, Mosul-Iraq.
Mousa YJ (2014) Anaesthetic properties of ketamine in chicks stressed with hydrogen peroxide. Vet Med 59:369-375.
Mousa YJ, Mohammad FK (2012a) Effects of hydrogen peroxide on diazepam and xylazine sedation in chicks. Interdiscip Toxicol 5:179-183.
Mousa YJ, Mohammad FK (2012b) The analgesic efficacy of xylazine and dipyrone in hydrogen peroxide-induced oxidative stress in chicks. Iraqi J Vet Sci 26:69-76.
Mousa YJ, Mohammad FK (2012c) Influence of hydrogen peroxide in drinking water on diazepam pharmacokinetics in chicks. Vet World 5:658-662.
Mousa YJ, Amin SM, Shaaban KhA (2021) Pharmacokinetics and plasma concentration of thiopental in normal and stressed chickens with hydrogen peroxide. J Hell Vet Med Soc 72(2): 2961-2968.
Mousa YJ (2021). Effect of nefopam in normal chickens and its relationship to hydrogen peroxide-induced oxidative stress. Iraqi J Vet Sci 35: in press.
Nade VS, Yadav AV (2010) Anti-stress effect of ethyl acetate soluble fraction of Morus alba in chronic restraint stress. Pharmaceut Biol 48:1038-1046.
Navarro A, Del Pino MJS, Gomez C, Peralta JL, Boveris A (2002) Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice. Am J Physiol Regul Integrative Comp Physiol 282:985-992.
Navasumrit P, Ward TH, Dodd NJF, O‘Connor PJ (2000) Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure. Carcinogen 21:93-99.
Pastore A, Federici G, Bertini E, Piemonte F (2003) Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333:19-39.
Patockova J, Marhol P, Tumova E, Krsiak M, Rokyta R, Stipek S, Crkovska J, Andel M (2003) Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia. Physiol Res 52:131-135.
Porcu P, Morrow AL (2014) Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: Relevance for human studies. Psychopharmacol 231:3257-3272.
Sarnowska A, Beresewicz M, Zablocka B, Domanska-Janik K (2009) Diazepam neuroprotection in excitotoxic and oxidative stress involves a mitochondrial mechanism additional to the GABAAR and hypothermic effects. Neurochem Interna 55:164-173.
Sayre LM, Perry G, Smith MA (2008) Oxidative stress and neurotoxicity. Chem Res Toxicol 21:172-188.
Srivastava KK, Kumar R (2015) Oxidative injury and disease. Indian J Clin Biochem 30:3-10.
Storz G, Imlay JA (1999) Oxidative stress. Curr Opin Microbiol 2:188-194.
Uehara T, Kurata K, Sumiyoshi T, Kurachi M (2003) Immobilization stress-induced increment of lactate metabolism in the basolateral amygdaloid nucleus is attenuated by diazepam in the rat. Eur J Pharmacol 459:211-215.
Weidauer E, Lehmann T, Ramisch A, Rohrdanz E, Foth H (2004) Response of rat alveolar type II cells and human lung tumor cells towards oxidative stress induced by hydrogen peroxide and paraquat. Toxicol Lett 151:69-78.
Wohaieb SA, Mohammad FK, Nadir HH (1994) Effects of hydrogen peroxide-induced oxidative stress on detomidine-ketamine anesthesia in male rabbits. Iraqi J Vet Sci 7:19-23.
Yaralioglu-Gurgoze S, Sindak N, Sahin T, Cen O (2005) Levels of glutathione peroxidase, lipoperoxidase and some biochemical and haematological parameters in gazelles anaesthetised with a tiletamine-zolazepam-xylazine combination. Vet J 169:126-128.
Zhang HY, McPherson BC, Liu H, Baman TS, Rock P, Yao Z (2002) H2O2 opens mitochondrial KATP channels and inhibits GABA receptors via protein kinase C- in cardiomyocytes. Am J Physiol Heart Circ Physiol 282:1395-1403.