Comparison of synchronisation protocols on pregnancy rate in dairy cows and heifers: A systematic review and network meta-analysis

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Veröffentlicht: Jul 9, 2023
Aktualisiert: 2023-07-09
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2023-07-09 (2)
DOI: https://doi.org/10.12681/jhvms.29829
P Ambarcioglu
Department of Biostatistics, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Turkey
D Mavridis
Department of Primary School Education, University of Ioannina, Ioannina, Greece
MO Yazlik
Department of Obstetrics and Gyneacology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey
R Vural
Department of Obstetrics and Gyneacology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey
MM Akcil Ok
Department of Nutrition and Dietetics, Faculty of Health Sciences, Baskent University, Ankara, Turkey
S Gürcan
Department of Biostatistics, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey
Abstract

Estrus synchronisation protocols are used as an essential strategy in the reproductive management of dairy herds, including Ovsynch, Presynch, Selectsynch, Heatsynch, Cosynch, Double-Ovsynch, and some other combinations of these, while the optimal protocol is still uncertain. We performed a network meta-analysis (NMA) to compare the efficacy of the synchronisation protocols in dairy cows and heifers. Pubmed, Scopus, Web of Science, Cabi Direct, and The Cochrane Library were searched up to May 13, 2019. The comparison of synchronisation protocols in terms of pregnancy rate was done by combining direct and indirect evidence. Ranking the synchronisation protocols were conducted by using surface under the cumulative ranking curve (SUCRA). 48 randomized trials involving 9 different protocols were included. Compared with the control group, none of the synchronisation protocols were more effective in pregnancy rate at first insemination. Presynch+Ovsynch was found to be more efficient than Ovsynch (RR=1.21, 95% CI:1.04-1.40), also Presynch+Ovsynch and Presynch+Heatsynch were superior to Presynch+Selectsynch (RR=2.01, 95% CI: 1.03-3.93 and RR=1.91, 95% CI: 1.21-3.01). In conclusion, presynchronisation strategies such as Presynch+Ovsynch increase the effectiveness of pregnancy rate at first insemination related to other synchronisation protocols. Nevertheless, the non-superiority of the synchronisation protocols against not applying any hormonal treatments should be considered in reproductive management in dairy herds.

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Literaturhinweise
Abe H, Masuda Y, Suzuki M (2009) Relationships between reproductive
traits of heifers and cows and yield traits for Holsteins in Japan. J.
Dairy Sci. 92:4055-4062.
Aksu EH, Bozkurt T, Türk G (2010) Effect of vitamin E on reproductive
performance in cows synchronized with different synchronization
methods. F. Ü. Sağ. Bil. Vet. Derg. 24:71-76.
Aréchiga CF, Staples CR, McDowell LR, Hansen PJ (1998) Effects of
timed insemination and supplemental β-carotene on reproduction and
milk yield of dairy cows under heat stress. J. Dairy Sci 81:390–402.
Bisinotto RS, Ribeiro ES, Santos JEP (2014) Synchronisation of ovulation
for management of reproduction in dairy cows. Animal 8:151–159.
Bisinotto RS, Lean IJ, Thatcher WW, Santos EP (2015) Meta-analysis of
progesterone supplementation during timed artificial insemination
programs in dairy cows. J. Dairy Sci 98:2472-2487.
Borchardt S, Haimerl P, Pohl A, Heuwiese W (2017) Evaluation of prostaglandin F2α versus prostaglandin F2α plus gonadotropin-releasing hormone as Presynch methods preceding an Ovsynch in lactating dairy
cows: A meta-analysis. J. Dairy Sci 100:4065-4077.
Bucher HC, Guyatt GH, Griffith LE, Walter SD (1997) The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J. Clin. Epidemiol 50:683–691.
Burke JM, De La Sota RL, Risco CA, Staples CR, Schmitt ÉJP, Thatcher
WW (1996) Evaluation of Timed Insemination Using a Gonadotropin-Releasing Hormone Agonist in Lactating Dairy Cows. J. Dairy
Sci 79:1385–1393.
Bülbül and Ataman (2005) Investigation of effect on fertility of different
oestrus synchronization methods in cows in field conditions. Vet. Bil.
Derg. 21:15-22.
Cartmill JA, El-Zarkouny SZ, Hensley BA, Lamb GC, Stevenson JS
(2001) Stage of cycle, incidence, and timing of ovulation, and pregnancy rates in dairy cattle after three timed breeding protocols. J.
Dairy Sci 84:1051-1059.
Cerri RLA, Santos JEP, Juchem SO, Galvão KN, Chebel RC (2004)
Timed artificial insemination with estradiol cypionate or insemination
at estrus in high-producing dairy cows. J. Dairy Sci 87:3704–3715.
Chaimani A, Higgins JPT, Mavridis D, Spyridonos P, Salanti G (2013)
Graphical Tools for Network Meta-Analysis in STATA. PLoS One
:e76654.
Chaimani A, Salanti G (2015) Visualizing assumptions and results in network meta-analysis: The network graphs package. The Stata Journal
:905-950.
Cipriani A, Higgins J, Geddes JR, Salanti G (2013) Research and Reporting Methods Annals of Internal Medicine Conceptual and Technical
Challenges in Network Meta-analysis. Ann. Intern. Med 159:130–
Cordoba MC, Fricke PM (2001)Evaluation of two hormonal protocols for
synchronisation of ovulation and timed artificial insemination in dairy
cows managed in grazing-based dairies. J. Dairy Sci 84:2700–2708.
Cordoba MC, Fricke PM (2002) Initiation of the breeding season in a
grazing-based dairy by synchronisation of ovulation. J. Dairy Sci
:1752–1763.
Dejarnette JM, Marshall CE (2003) Effects of pre-synchronisation using
combinations PGF2α and (or) GnRH on pregnancy rates of Ovsynchand Cosynch-treated lactating Holstein cows. Anim. Reprod. Sci
:51–60.
DeJarnette JM, Salverson RR, Marshall CE (2001) Incidence of premature estrus in lactating dairy cows and conception rates to standing
estrus or fixed-time inseminations after synchronisation using GnRH
and PGF2α. Anim. Reprod. Sci 67:27–35.
Dias S, Welton NJ, Caldwell DM, Ades AE (2010) Checking consistency
in mixed treatment comparison meta-analysis. Stat. Med 29:932–944.
Gordon MB, Dinn N, Rajamahendran R (2010) Effects of presynchronisation and postinsemination treatments on pregnancy rates to a timed
breeding Ovsynch protocol in dairy cows and heifers. Can. J. Anim.
Sci. 90:35–44.
Gumen A, Keskin A, Yilmazbas-Mecitoglu G, Karakaya E, Alkan A, Okut
H, Wiltbank MC (2012) Effect of presynchronization strategy before
Ovsynch on fertility at first service in lactating dairy cows. Theriogenology 78:1830-1838.
Higgins JPT, Green s (2008) Assessing risk of bias in included studies. In:
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series. John Wiley & Sons, Inc., pp:187-241.
Higgins JPT, Jackson D, Barrett JK, Lu G, Ades AE, White IR (2012)
Consistency and inconsistency in network meta‐analysis: concepts
and models for multi‐arm studies. Res. Synth. Methods 3:98–110.
Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron
C, Ioannidis JPA, Starus S, Thorlund K, Jansen JP, Mulrow C, Catala-Lopez F, Gotzsche PC, Dickersin K, Boutron I, Altman DG, Moher
D (2015) The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 162:777-784.
Iwakuma A, Narahashi T, Kitahara G, Ohkubo M, Kamimura S (2008)
Efficacy of intravaginal progesterone administration as an additional
treatment on two types of timed AI protocols in a commercial herd of
Holstein heifers. J. Vet. Med. Sci. 70:243–249.
Kaçar C, Kamiloğlu NN, Uçar Ö, Arı UÇ, Pancarcı ŞM, Güngör Ö (2008)
Effect of Ovsynch and Cosynch synchronisation programmes combined with β-carotene+vitamin E administration upon the pregnancy
rates in cows. Kafkas Üniv Vet Fak Derg 14:45-50.
Karakas E, Nak Y, Nak D (2009) Effects on reproductive parameters of
cosynch, ovsynch and ovsynch+cosynch administration in unobserved estrous cows and heifers. Cattle Pract. 17:84–89.
Karimi A, Karami H, Moini MM, Sefat AAA, Haghvirdilu E (2007)
Comparison between different protocols of synchronisation and their
efficiency on pregnancy rate of dairy cattle. Pakistan J. Biol. Sci.
:3557–3563.
Kasimanickam R (2021) Pharmacological intervention of estrous cycles.
In: Bovine Reproduction. 2nd Ed, John Wiley & Sons, Inc., pp:458-
King GJ, Robertson HA (1974) A two injection schedule with prostaglandin F2α for the regulation of the ovulatory cycle of cattle. Theriogenology 1:123–128.
Lane EA, Austin EJ, Crowe MA (2008) Oestrous synchronisation in cattle-Current options following the EU regulations restricting use of
oestrogenic compounds in food-producing animals: A review. Anim.
Reprod. Sci. 109:1–16.
Lean IJ, Porter JA, Rabiee AR, Morgan WF, Tranter WP, Moss N, Rheinberger RJ (2003) Comparison of effects of GnRH and prostaglandin
in combination, and prostaglandin on conception rates and time to
conception in dairy cows. Australian Veterinary Journal 81:488-493.
Lindley G, Willshire J, Martin A (2021) Controlled breeding in dairy
cows. Part 1: bovine oestrus cycle and synchronisation. In Practice
:445-456.
Mavridis D, Giannatsi M, Cipriani A, Salanti G (2015) A primer on network meta-analysis with emphasis on mental health. Evid. Based.
Ment. Health 18:40–46.
Momcilovic D, Archbald LF, Walters A, Tran T, Kelbert D, Risco C,
Thatcher WW (1998) Reproductive performance of lactating dairy
cows treated with gonadotropin-releasing hormone (GnRH) and/or
prostaglandin F2α (PGF2α) for synchronisation of estrus and ovulation. Theriogenology 50:1131–1139.
Moreira F, Orlandi C, Risco CA, Mattos R, Lopes F, Thatcher WW (2001)
Effects of presynchronisation and bovine somatotropin on pregnancy rates to a timed artificial insemination protocol in lactating dairy
cows. J. Dairy Sci. 84:1646-1659.
Nak Y, Tuna B, Nak D, Karakaş E, Şimşek G (2009) Kızgınlıkları Gözlenemeyen Sütçü İnek ve Düvelerde, Ovsynch, Ovysnch - Progestin, Ovsynch - Progestin - Çift Sun’i Tohumlama Uygulamalarının
Gebelik Oranları Üzerine Etkileri. Kafkas Univ. Vet. Fak. Derg.
:917–922
Pancarci SM, Jordan ER, Risco CA, Schouten MJ, Lopes FL, Moreira
F, Thatcher WW (2002) Use of estradiol cypionate in a presynchronized timed artificial insemination program for lactating dairy cattle.
J. Dairy Sci. 85:122–131.
Pursley JR, Kosorok MR, Wiltbank MC (1997) Reproductive Management of Lactating Dairy Cows Using Synchronisation of Ovulation.
J. Dairy Sci. 80:301–306.
Pursley JR, Mee MO, Wiltbank MC (1995) Synchronisation of ovulation
in dairy cows using PGF2α and GnRH. Theriogenology 44:915–923.
Rabiee AR, Lean IJ, Stevenson MA (2004) A Bayesian meta-analysis of
the effects of administering an inra-vaginal (CIDR) device in combination with other hormones on the reproductive performance of
cycling, anoestrous and inseminated cows. New Zealand Veterinary
Journal, 52:384-393.
Rabiee AR, Lean IJ, Stevenson MA (2005) Efficacy of Ovsynch Program
on Reproductive Performance in Dairy Cattle : A Meta-Analysis. J.
Dairy Sci. 88:2754-2770.
Salanti G (2012) Indirect and mixed-treatment comparison, network,
or multiple-treatments meta-analysis: many names, many benefits,
many concerns for the next generation evidence synthesis tool. Res.
Synth. Methods 3:80–97.
Salanti G, Ades AE, Ioannidis JPA (2011) Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: An overview and tutorial. J. Clin. Epidemiol. 64:163–171.
Souza AH, Ayres H, Ferreira RM, Wiltbank MC (2008) A new presynchronisation system (Double-Ovsynch) increases fertility at first postpartum timed AI in lactating dairy cows. Theriogenology 70:208–215.
Stevenson JL (2006) Treatment of Cycling and Noncycling Lactating Dairy Cows with Progesterone During Ovsynch. J. Dairy Sci.
:2567–2578.
Stevenson JL, Rodrigues JA, Braga FA, Bitente S, Dalton JC, Santos JEP,
Chebel RC (2008) Effect of breeding protocols and reproductive tract
score on reproductive performance of dairy heifers and economic outcome of breeding programs. J. Dairy Sci. 91:3424–3438.
Stevenson JS, Smith JF, Hawkins DE (2000) Reproductive outcomes for
dairy heifers treated with combinations of prostaglandin F2α, norgestomet, and gonadotropin-releasing hormone. J. Dairy Sci. 83:2008–
Tenhagen BA, Drillich M, Surholt R, Heuwieser W (204) Comparison of
timed AI after synchronized ovulation to AI at estrus: Reproductive
and economic considerations. J. Dairy Sci. 87:85–94.
Tibary A, Patino C, Ciccarelli M (2019) Synchronisation of Estrus and
Ovulation in Dairy Cattle. Spermova 9:1–13.
Veroniki AA, Higgins HSV, Salanti G (2013) Evaluation of inconsistency
in networks of interventions. Int. J. Epidemiol. 42:332–345.
Yan L, Robinson R, Shi Z, Mann G (2016) Efficacy of progesterone supplementation during early pr