Current Approaches in the Diagnosis and Treatment of Canine Otitis
Abstract
As a disease with high prevalence in canine, otitis externa (OE) requires a summary of its diagnosis and treatment. Since antimicrobials are predominantly used in OE treatment, their prudent use must be in focus due to significant impact on the spread and development on the antimicrobial resistance (AMR). Furthermore, as AMR is constantly increasing, further studies are required to create novel treatment approaches against causative agents. Therefore, new alternative approaches to antimicrobials and antifungals were investigated to discover an effective approach to OE treatment. In addition to diagnosis and conventional treatment, this review aimed to summarize the findings of various publications related to the usage of essential oils against OE associated pathogens. While there are very few in vivo trials, numerous in vitro studies have demonstrated the effectiveness of essential oils and their potential application in OE treatment. New alternative approaches are leading toward the development of new treatment objectives and alternatives.
Article Details
- Zitationsvorschlag
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Tešin, N., & Kovačević, Z. (2025). Current Approaches in the Diagnosis and Treatment of Canine Otitis. Journal of the Hellenic Veterinary Medical Society, 76(1), 8767–8778. https://doi.org/10.12681/jhvms.37592
- Ausgabe
- Bd. 76 Nr. 1 (2025)
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- Review Articles
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Literaturhinweise
Angus JC (2004) Otic cytology in health and disease. Vet Clin North Am
Small Anim Pract 34: 411-424.
Bajwa J (2019) Canine otitis externa—Treatment and complications. Can
Vet J 60: 97.
Bismarck D, Dusold A, Heusinger A, Müller E (2020) Antifungal in vitro
activity of essential oils against clinical isolates of Malassezia pachydermatis
from canine ears: a report from a practice laboratory. Complement
Med Res 27: 143-154.
Bugden D (2013) Identification and antibiotic susceptibility of bacterial
isolates from dogs with otitis externa in Australia. Aust Vet J 91: 43-
Chickering WR (1988) Cytologic evaluation of otic exudates. Vet Clin
North Am Small Anim Pract 18: 773-782.
Cole LK (2004) Otoscopic evaluation of the ear canal. Vet Clin North Am
Small Anim Pract 34: 397-410.
De Martino L, Nocera FP, Mallardo K, Nizza S, Masturzo E, Fiorito F,
Iovane G, Catalanotti P (2016) An update on microbiological causes
of canine otitis externa in Campania Region. Italy Asian Pac J Trop
Biomed 6: 384-389.
Ebani VV, Bertelloni F, Najar B, Nardoni S, Pistelli L, Mancianti F (2020)
Antimicrobial activity of essential oils against Staphylococcus and
Malassezia strains isolated from canine dermatitis. Microorganisms
: 252.
Ebani VV, Mancianti F (2020) Use of essential oils in veterinary medicine
to combat bacterial and fungal infections. Vet Sci 7: 193.
Ebani VV, Nardoni S, Bertelloni F, Najar B, Pistelli L, Mancianti F (2017)
Antibacterial and antifungal activity of essential oils against pathogens
responsible for otitis externa in dogs and cats. Medicines 4: 21.
Ebani VV, Pieracci Y, Cagnoli G, Bertelloni F, Munafò C, Nardoni S, Pistelli
L, Mancianti F (2023) In Vitro Antimicrobial Activity of Thymus
vulgaris, Origanum vulgare, Satureja montana and Their Mixture
against Clinical Isolates Responsible for Canine Otitis Externa. Vet
Sci 10: 30.
Friedman ND, Temkin E, Carmeli Y (2016) The negative impact of antibiotic
resistance. Clin Microbiol Infect 22 416-422.
Garosi LS, Dennis R, Schwarz T (2003) Review of diagnostic imaging of
ear diseases in the dog and cat. Vet Radiol Ultrasound 44: 137-146.
Gotthelf LN (2004) Diagnosis and treatment of otitis media in dogs and
cats. Vet Clin North Am Small Anim Pract 34: 469-487.
Guarda F, Mandelli G, Biolatti B, Scanziani E (2013) Organi di senso,
orecchio. In: Trattato di anatomia patologica veterinaria. 4th ed, Utet
Medica, Torino: pp 655-657.
Hariharan H, Coles M, Poole D, Lund L, Page R (2006) Update on antimicrobial
susceptibilities of bacterial isolates from canine and feline
otitis externa. Can Vet J 47: 253.
Hopman NE, Portengen L, Hulscher ME, Heederik DJ, Verheij T, Wagenaar
JA, Prins JM, Bosje T, Schipper L, Van Geijlswijk IM (2019)
Implementation and evaluation of an antimicrobial stewardship programme
in companion animal clinics: A stepped-wedge design intervention
study. PLoS One 14: e0225124.
Horváth G, Ács K (2015) Essential oils in the treatment of respiratory
tract diseases highlighting their role in bacterial infections and their
anti‐inflammatory action: a review. Flavour Fragr J 30: 331-341.
Jacobson L (2002) Diagnosis and medical treatment of otitis externa in the
dog and cat. J S Afr Vet Assoc 73: 162-170.
Kasai T, Fukui Y, Aoki K, Ishii Y, Tateda K (2021) Changes in the ear
canal microbiota of dogs with otitis externa. J Appl Microbiol 130:
-1091.
Khosravi A, Shokri H, Fahimirad S (2016) Efficacy of medicinal essential
oils against pathogenic Malassezia sp. isolates. J Mycol Méd 26:
-34.
Kim J-Y, Olivry T, Son W-G (2012) Characteristics of Malassezia pachydermatis
Isolated from Dogs and Antifungal Effect of Essential Oils.
J Vet Clin 29: 141-147.
King S, Doucette K, Seewald W, Forster S (2018) A randomized, controlled,
single-blinded, multicenter evaluation of the efficacy and
safety of a once weekly two dose otic gel containing florfenicol, terbinafine
and betamethasone administered for the treatment of canine
otitis externa. BMC Vet Res 14: 1-9.
Kiss G, Radvanyi S, Szigeti G (1997) New combination for the therapy of
canine otitis externa I Microbiology of otitis externa. J Small Anim
Pract 38: 51-56.
Kovačević Z, Mihajlović J, Mugoša S, Horvat O, Tomanić D, Kladar N,
Samardžija M (2022a) Pharmacoeconomic Analysis of the Different
Therapeutic Approaches in Control of Bovine Mastitis: Phytotherapy
and Antimicrobial Treatment. Antibiotics 12: 11.
Kovačević Z, Tomanić D, Čabarkapa I, Šarić L, Stanojević J, Bijelić K,
Galić I, Ružić Z, Erdeljan M, Kladar N (2022b) Chemical Composition,
Antimicrobial Activity, and Withdrawal Period of Essential Oil-
Based Pharmaceutical Formulation in Bovine Mastitis Treatment. Int
J Environ Res Public Health 19: 16643.
Lehner G, Sauter Louis C, Mueller R (2010): Reproducibility of ear cytology
in dogs with otitis externa. Vet Rec 167: 23-26.
Little C (1996) Medical treatment of otitis externa in the dog and cat. In
Pract 18: 66-71.
Lorek A, Dennis R, van Dijk J, Bannoehr J (2020) Occult otitis media in dogs with chronic otitis externa-magnetic resonance imaging and
association with otoscopic and cytological findings. Vet Dermatol 31:
-e28.
Lund EM, Armstrong PJ, Kirk CA, Kolar LM, Klausnor J (1999) Health
status and population characteristics of dogs and cats examined at
private veterinary practices in the United States. J Am Vet Med Assoc
: 1336-1341.
Lyskova P, Vydrzalova M, Mazurova J (2007) Identification and antimicrobial
susceptibility of bacteria and yeasts isolated from healthy
dogs and dogs with otitis externa. J Vet Med A 54: 559-563.
Metiner K, Çelik B, Kahraman BB, Siğirci BD, Mavili ZS, Seyyal A
(2015) Occurrence of Malassezia pachydermatis in dogs with otitis
externa. J Fac Vet Med Istanbul Univ 42: 117-121.
Miller WH, Griffin CE, Campbell KL (2013) Diseases of eyelids, claws,
anal sacs and ears. In: Muller & Kirk’s Small Animal Dermatology.
th ed, St. Louis, Missouri: pp 724-773.
Morris DO (2004) Medical therapy of otitis externa and otitis media. Vet
Clin North Am. Small Anim Pract 34: 541-555.
Mugoša S, Vračar V, Tešin N, Mitrović J, Tomanić D, Kovačević Z (2023)
Antimicrobial veterinary drug sale pattern in correlation with critically
important antimicrobials for human use: A five-year study in
Montenegro. Acta Microbiol Immuno Hung 70: 340-347.
Murphy KM (2001) A review of techniques for the investigation of otitis
externa and otitis media. Clin Tech Small Anim Pract 16: 236-241.
Nardoni S, Pistelli L, Baronti I, Najar B, Pisseri F, Bandeira Reidel Rv,
Papini R, Perrucci S, Mancianti F (2017) Traditional Mediterranean
plants: Characterization and use of an essential oils mixture to treat
Malassezia otitis externa in atopic dogs. Nat Prod Res 31: 1891-1894.
Neves RC, Makino H, Cruz TP, Silveira MM, Sousa VR, Dutra V, Lima
ME, Belli CB (2018) In vitro and in vivo efficacy of tea tree essential
oil for bacterial and yeast ear infections in dogs. Pesqui Vet Bras 38:
-1607.
Nuttall T (2016) Successful management of otitis externa. In Pract 38:
-21.
NuttalL T (2023) Managing recurrent otitis externa in dogs: what have
we learned and what can we do better? J Am Vet Med Assoc 261:
S10-S22.
Packer JF, Luz M (2007) Método para avaliação e pesquisa da atividade
antimicrobiana de produtos de origem natural. Rev Bras Farmacogn
: 102-107.
Paterson S (2016) Discovering the causes of otitis externa. In Pract 38:
-11.
Pelligand L, Baker D, Sivagurunathan A, Kovačević Z, Suemanotham
N, Stair J, Scott M, Liu F, Page S, Guardabassi L (2023) Quality of
amoxicillin/clavulanic acid oral formulations for intended veterinary
use in the UK, Malaysia, Serbia and Thailand. J Small Anim Pract
: 626-634.
Petrov V, Mihaylov G, Tsachev I, Zhelev G, Marutsov P, Koev K (2013)
Otitis externa in dogs: microbiology and antimicrobial susceptibility.
Revue Méd Vét 164: 18-22.
Pomba C, Rantala M, Greko C, Baptiste KE, Catry B, Van Duijkeren E,
Mateus A, Moreno MA, Pyörälä S, Ružauskas M (2017) Public health
risk of antimicrobial resistance transfer from companion animals. J
Antimicrob Chemother 72: 957-968.
Posadzki P, Alotaibi A, Ernst E (2012) Adverse effects of aromatherapy:
A systematic review of case reports and case series. Int J Risk Saf
Med 24: 147-161.
Puigdemont A, D’andreano S, Ramió‐Lluch L, Cuscó A, Francino O, Brazis
P (2021) Effect of an anti‐inflammatory pomegranate otic treatment
on the clinical evolution and microbiota profile of dogs with
otitis externa. Vet Dermatol 32: 158-e37.
Pye C (2018) Pseudomonas otitis externa in dogs. Can Vet J 59: 1231.
Rosser EJ (2004) Causes of otitis externa. Vet Clin North Am Small Anim
Pract 34: 459-468.
Rougier S, Borell D, Pheulpin S, Woehrlé F, Boisramé B (2005) A comparative
study of two antimicrobial/anti‐inflammatory formulations
in the treatment of canine otitis externa. Vet Dermatol 16: 299-307.
Saridomichelakis MN, Farmaki R, Leontides LS, Koutinas AF (2007) Aetiology
of canine otitis externa: a retrospective study of 100 cases. Vet
Dermatol 18: 341-347.
Scherer CB, Botoni LS, Coura FM, Silva RO, Santos RDD, Heinemann
MB, Costa-Val AP (2018) Frequency and antimicrobial susceptibility
of Staphylococcus pseudintermedius in dogs with otitis externa.
Ciênc Rural 48: e20170738.
Scott D, Miller W, Griffin C (2001) Diseases of eyelids, claws, anal sacs,
and ears. In: Muller and Kirk’s Small Animal Dermatology. 6th ed, W.
B. Saunders, Philadelphia (PA): pp 1185-1235.
Silva KCD, Knobl T, Moreno AM (2013) Antimicrobial resistance in veterinary
medicine: mechanisms and bacterial agents with the greatest
impact on human health. Braz J Vet Res Anim Sci 50:171-183.
Sim J, Khazandi M, Pi H, Venter H, Trott D, Deo P (2019a) Antimicrobial
effects of cinnamon essential oil and cinnamaldehyde combined with
EDTA against canine otitis externa pathogens. J Appl Microbiol 127:
-108.
Sim JXF, Khazandi M, Chan WY, Trott DJ, Deo P (2019b) Antimicrobial
activity of thyme oil, oregano oil, thymol and carvacrol against sensitive
and resistant microbial isolates from dogs with otitis externa. Vet
Dermatol 30: 524-e159.
Spinosa HDS, Górniak SL, Bernardi MM (2006) Farmacologia aplicada
à medicina veterinária. 5th ed, Guanabara Koogan, Rio de Janeiro:
pp 361-433.
Steagall P, Pelligand L, Page S, Bourgeois M, Weese S, Manigot G, Dublin
D, Ferreira J, Guardabassi L (2020) The World Small Animal Veterinary
Association (WSAVA): list of essential medicines for cats and
dogs. J Small Anim Pract 61:E162-E176.
Tešin N, Stančić I, Kanački Z, Spasojević J, Ružić Z, Galić I, Kovačević
Z (2023a) Prevalence and infestation degree of yeast in canine otitis
externa. Vet. stanica. 54: 655-663.
Tesin N, Stojanovic D, Stancic I, Kladar N, Ružić Z, Spasojevic J, Tomanic
D, Kovacevic Z (2023b) Prevalence of the microbiological causes
of canine otitis externa and the antibiotic susceptibility of the isolated
bacterial strains. Pol J Vet Sci 26: 449-459.
Tešin N, Tomanić D, Galić I, Ačanski A, Kovačević Z (2023c) Staphylococcus
pseudintermedius occurrence and its antibiotic susceptibility
pattern in case of canice otitis externa. In: Book of Abstracts and
Conference Proceedings 2nd International Conference Antimicrobial
resistance in veterinary medicine-current state and perspectives, Novi
Sad, Serbia: pp 90-98.
Tomanić D, Božin B, Čabarkapa I, Kladar N, Radinović M, Maletić M,
Kovačević Z (2022a) Chemical composition, antioxidant and antibacterial
activity of two different essential oils against mastitis associated
pathogens. Acta Vet 72: 45-58.
Tomanić D, Božin B, Kladar N, Stanojević J, Čabarkapa I, Stilinović
N, Apić J, Božić DD, Kovačević Z (2022b) Environmental bovine
mastitis pathogens: prevalence, antimicrobial susceptibility, and sensitivity
to Thymus vulgaris L., Thymus serpyllum L., and Origanum
vulgare L. essential oils. Antibiotics 11: 1077.
Tomanić D, Kladar N, Radinović M, Stančić I, Erdeljan M, Stanojević J,
Galić I, Bijelić K, Kovačević Z (2023a) Intramammary Ethno-Veterinary
Formulation in Bovine Mastitis Treatment for Optimization of
Antibiotic Use. Pathogens 12: 259.
Tomanić D, Samardžija M, Kovačević Z (2023b) Alternatives to Antimicrobial
Treatment in Bovine Mastitis Therapy: A Review. Antibiotics
: 683.
Tomanić DZ, Stanojević JB, Galić IM, Ružić ZN, Kukurić TB, Tešin NB,
Prpa BP, Kovačević ZR (2022c) Review of trends in essential oils as
alternatives to antibiotics in bovine mastitis treatment. Matica Srpska
J Nat Sci 142: 47-60.
Türkyilmaz S (2008) Antibiotic susceptibility patterns of Pseudomonas
aeruginosa strains isolated from dogs with otitis externa. Turk J Vet
Anim Sci 32:37-42.
Váczi P, Čonková E, Marcinčáková D, Sihelská Z (2018) Antifungal effect
of selected essential oils on Malassezia pachydermatis growth. Folia
Vet 62: 67-72.
Vercelli C, Pasquetti M, Giovannetti G, Visioni S, Re G, Giorgi M, Gambino
G, Peano A (2021) In vitro and in vivo evaluation of a new phytotherapic
blend to treat acute externa otitis in dogs. J Vet Pharmacol
Ther 44: 910-918.
Waller SB, Ripoll MK, Silva AL, Serra EF, Dias TP, Neves VBD, Melo
LPD, Lindemann P, Martins ODA, Gomes ADR (2022) Activities
and mechanisms of oregano, marjoram and rosemary essential oils
against Malassezia pachydermatitis isolates from canine and feline otitis. Turk J Vet Anim Sci 46: 549-558.
White P D (1999) Medical management of chronic otitis in dogs. Compend
Contin Educ Vet 21: 716-728.
Wong C, Epstein S, Westropp J (2015) Antimicrobial susceptibility patterns
in urinary tract infections in dogs (2010-2013). J Vet Intern Med
: 1045-1052.
Woodwars M (2022) Otitis externa in animals. In: MERCK Veterinary
otitis-externa-in-animals [Accessed 20 October 2023].
Zamankhan Malayeri H, Jamshidi S, Zahraei Salehi T (2010) Identification
and antimicrobial susceptibility patterns of bacteria causing otitis
externa in dogs. Vet Res Commun 34: 435-444.
