Relationship of serum adiponectin and IGF-I concentrations with progesterone and their effect on pregnancy rates in cows

PDF (English)
Δημοσιευμένα: Jul 10, 2022
DOI: https://doi.org/10.12681/jhvms.27005
H Alkan
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
https://orcid.org/0000-0001-9177-9299
MF Ciftci
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
ÖF Yesilkaya
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
K Karakas Alkan
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
F Satilmis
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
MA Tekindal
Katip Celebi University, Faculty of Medicine, Department of Biostatistics, İzmir, Turkey
H Erdem
Selcuk University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Konya, Turkey
Περίληψη

The aims of this study were to determine serum adiponectin and insulin-like growth factor-I (IGF-I) concentrations in early and late luteal phases following artificial insemination, to evaluate their relationship with progesterone concentrations, and to detect their effects on the pregnancy rate. We used 45 Holstein cows aged 3–4 years who had given birth at least once and who did not have any problem in the genital system as observed on rectal palpation/ultrasonography examination. Presynch–ovsynch synchronization protocol was applied on cows. Blood samples were collected to determine the concentrations of progesterone, adiponectin, and IGF-I on days 5 and 18 following artificial insemination. Pregnancy examination using real-time ultrasonography was performed on day 30 following artificial insemination. Fifteen (33.33%) of the 45 cows were determined as pregnant. The pregnancy rates were increased with increasing progesterone concentration on day 5 following artificial insemination, and the pregnancy rates were the highest (53.84%) among the cows with progesterone concentration of >2.00 ng/mL. Adiponectin and IGF-I concentrations were determined as 26.69±11.84 vs 24.14±9.19 and 17.52±4.19 vs 17.42±2.92, on days 5 and 18 after artificial insemination, respectively (P>0.05). Negative correlation was observed between adiponectin and progesterone concentrations (P<0.05), whereas positive correlation was observed between IGF-I and progesterone on day 5 following artificial insemination (P<0.05). Progesterone and IGF-I concentrations in pregnant cows were higher than in nonpregnant cows on days 5 and 18 following artificial insemination (P<0.05). In conclusion, the progesterone and IGF-I concentrations in early and late luteal phase following artificial insemination had a positive effect on the pregnancy rate. However, although early adiponectin concentration affected progesterone concentrations, it did not affect the pregnancy rate.

Λεπτομέρειες άρθρου
  • Ενότητα
  • Research Articles
Creative Commons License

Αυτή η εργασία είναι αδειοδοτημένη υπό το CC Αναφορά Δημιουργού – Μη Εμπορική Χρήση 4.0.

Οι συγγραφείς των άρθρων που δημοσιεύονται στο περιοδικό διατηρούν τα δικαιώματα πνευματικής ιδιοκτησίας επί των άρθρων τους, δίνοντας στο περιοδικό το δικαίωμα της πρώτης δημοσίευσης.

Άρθρα που δημοσιεύονται στο περιοδικό διατίθενται με άδεια Creative Commons 4.0 Non Commercial και σύμφωνα με την άδεια μπορούν να χρησιμοποιούνται ελεύθερα, με αναφορά στο/στη συγγραφέα και στην πρώτη δημοσίευση για μη κερδοσκοπικούς σκοπούς.

Οι συγγραφείς μπορούν να καταθέσουν το άρθρο σε ιδρυματικό ή άλλο αποθετήριο ή/και να το δημοσιεύσουν σε άλλη έκδοση, με υποχρεωτική την αναφορά πρώτης δημοσίευσης στο J Hellenic Vet Med Soc

Οι συγγραφείς ενθαρρύνονται να καταθέσουν σε αποθετήριο ή να δημοσιεύσουν την εργασία τους στο διαδίκτυο πριν ή κατά τη διαδικασία υποβολής και αξιολόγησής της.

Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Bilodeau-Goeseels S, Kastelic JP (2003) Factors affecting embryo survival
and strategies to reduce embryonic mortality in cattle. Can J Anim
Sci, 83 (4): 659-671.
Block J (2007) Use of insulin-like growth factor-1 to improve post-transfer
survival of bovine embryos produced in vitro. Theriogenology,
(S1): 49-55.
Block J, Hansen PJ (2007) Interaction between season and culture with
insulin-like growth factor-1 on survival of in vitro produced embryos
following transfer to lactating dairy cows. Theriogenology, 67 (9):
-1529.
Campos DB, Palin MF, Bordignon V, Murphy BD (2008) The “beneficial”
adipokines in reproduction and fertility. Int J Obes, 32 (2): 223-231.
Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki
AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell
RG, Lindemann D, Hartley A, Baker GRC, Obici S, Deshaies Y,
Ludgate M, Rossetti L, Scherer PE (2004) A transgenic mouse with a
deletion in the collagenous domain of adiponectin displays elevated
circulating adiponectin and improved insulin sensitivity. Endocrinology,
(1): 367-383.
de Koster J, Urh C, Hostens M, van den Broeck W, Sauerwein H, Opsomer
G (2017) Relationship between serum adiponectin concentration,
body condition score, and peripheral tissue insulin response of dairy
cows during the dry period. Domest Anim Endocrinol, 59: 100-104.
Dobrzyn K, Smolinska N, Szeszko K, Kiezun M, Maleszka A, Rytelewska
E, Kaminski T (2017) Effect of progesterone on adiponectin system
in the porcine uterus during early pregnancy. J Anim Sci, 95 (1): 338.
dos Santos E, Serazin V, Morvan C, Torre A, Wainer R, de Mazancourt
P, Dieudonné MN (2012) Adiponectin and leptin systems in human
endometrium during window of implantation. Fertil Steril, 97 (3):
-778.
dos Santos E, Pecquery R, de Mazancourt P, Dieudonné MN (2012) Adiponectin
and reproduction. VitamHorm, 90: 187-209.
Gobikrushanth M, Purfield DC, Colazo MG, Wang Z, Butler ST, Ambrose
DJ (2018) The relationship between serum insulin-like growth factor-
(IGF-1) concentration and reproductive performance, and genome-
wide associations for serum IGF-1 in Holstein cows. J Dairy
Sci, 101 (10): 9154-9167.
Gupta M, Bahiram KB, Sardar VM, Korde JP, Magar SP, Bonde SW,
Kurkure NV (2019) Expression and localization of adiponectin and
its receptors in ovarian follicles during different stages of development
and the modulatory effect of adiponectin on steroid production
in water buffalo. Reprod DomestAnim, 54 (9): 1291-1303.
Heinz JFL, Singh SP, Janowitz U, Hoelker M, Tesfaye D, Schellander K,
Sauerwein H (2015) Characterization of adiponectin concentrations
and molecular weight forms in serum, seminal plasma, and ovarian
follicular fluid from cattle. Theriogenology, 83 (3): 326-333.
Kafi M, Tamadon A, Saeb M (2015) The relationship between serum adiponectin
and postpartum luteal activity in high-producing dairy cows.
Theriogenology, 83 (8): 1264-1271.
Kalamaras KD (2012) The role of adiponectin in regulation of metabolism
in dairy cows. PhD thesis, University of Nottingham, Division
of Animal Sciences School of Biosciences Sutton Bonington Campus
United Kingdom.
Kul E, Erdem H (2018) Relationships between milk insulin-like growth
factor-i (IGF-I) concentration and Body condition score with reproductive
performance and milk yield in Jersey cows. Large Anim Rev,
: 65-70.
Lagaly DV, Aad PY, Grado-Ahuir JA, Hulsey LB, Spicer LJ (2008) Role
of adiponectin in regulating ovarian theca and granulosa cell function.
Mol Cell Endocrinol, 284 (1-2): 38-45.
Maillard V, Uzbekova S, Guignot F, Perreau C, Ramé C, Coyral-Castel S,
Dupont J (2010) Effect of adiponectin on bovine granulosa cell steroidogenesis,
oocyte maturation and embryo development. Reprod-
Biol Endocrinol, 8 (23): 1-15.
Maleszka A, Smolinska N, Nitkiewicz A, Kiezun M, Chojnowska K, Dobrzyn
K, Szwaczek H, Kaminski T (2014). Adiponectin expression in
the porcine ovary during the oestrous cycle and its effect on ovarian
steroidogenesis. Int J Endocrinol, Article ID 957076.
Mann GE, Lamming GE (1999). The influence of progesterone during
early pregnancy in cattle. Reprod Domest Anim, 34 (3-4): 269-274.
McNeill RE, Diskin MG, Sreenan JM, Morris DG (2006) Associations
between milk progesterone concentration on different days and with
embryo survival during the early luteal phase in dairy cows. Theriogenology,
(7): 1435-1441.
Morris D, Diskin M (2008). Effect of progesterone on embryo survival.
Animal, 2 (8): 1112-1119.
O’Hara L, Forde N, Carter F, Rizos D, Maillo V, Ealy AD, Kelly AK,
Rodriguez P, Isaka N, Evans ACO, Lonergan P (2014). Paradoxical
effect of supplementary progesterone between day 3 and day 7 on
corpus luteum function and conceptus development in cattle. Reprod-
Fertil Dev, 26 (2): 328-336.
Pushpakumara PGA, Robinson RS, Demmers KJ, Mann GE, Sinclair KD,
Webb R, Wathes DC (2002) Expression of the insulin-like growth
factor (IGF) system in the bovine oviduct at oestrus and during early
pregnancy. Reproduction, 123 (6): 859-868.
Ribeiro E, de S, Spricigo JFW, Carvalho MR, Ticiani E (2018) Physiological
and cellular requirements for successful elongation of the preimplantation
conceptus and the implications for fertility in lactating
dairy cows. Anim Reprod, 15: 765-783.
Ribeiro ES, Greco LF, Bisinotto RS, Lima FS, Thatcher WW, Santos JE
(2016) Biology of preimplantation conceptus at the onset of elongation
in dairy cows. BiolReprod, 94 (4): 1-18.
Samardžija M, Dobranić T, Vince S, Cergolj M, Tomašković A, Đurić
K, Grizelj J, Karadjole M, Gračner D, Pavičić Ž (2006) Correlation
between progesterone P4, insulin like growth factor I, metabolic parameters
and ovarian cyclicity of cows in puerperium. Tierärztliche
Umschau, 61 (8): 421-427.
Sauerwein H, Häußler S (2016) Endogenous and exogenous factors influencing
the concentrations of adiponectin in body fluids and tissues in
the bovine. Domest Anim Endocrinol, 56: 33-43.
Senger PL (2005) Pathways to pregnancy and parturition. Current Conceptions.
nd Revised Ed., Inc. Pullman, Washington, USA.
Smolinska N, Kiezun M, Dobrzyn K, Szeszko K, Maleszka A, Kaminski
T (2017) Adiponectin, orexin A and orexin B concentrations in the
serum and uterine luminal fluid during early pregnancy of pigs. Anim
Reprod Sci, 178: 1-8.
Smolinska N, Maleszka A, Dobrzyn K, Kiezun M, Szeszko K, Kaminski
T (2014) Expression of adiponectin and adiponectin receptors 1 and
in the porcine uterus, conceptus, and trophoblast during early pregnancy.
Theriogenology, 82 (7): 951-965.
Spencer TE, Forde N, Lonergan P (2015) The role of progesterone and
conceptus-derived factors in uterine biology during early pregnancy
in ruminants. J Dairy Sci, 99 (7): 5941-5950.
Spicer LJ, Alpizar E, Echternkamp SE (1993) Effects of insulin, insulin-
like growth factor I, and gonadotropins on bovine granulosa cell
proliferation, progesterone production, estradiol production, and (or)
insulin-like growth factor I production in vitro. J Anim Sci, 71 (5):
-1241.
Spicer LJ, Chamberlain CS, Maciel SM (2002) Influence of gonadotropins
on insulin-and insulin-like growth factor-I (IGF-I)-induced
steroid production by bovine granulosa cells. Domest Anim Endocrinol,
: 237-254.
Spicer LJ, Tucker WB, Adams GD (1990) Insulin-like growth factor-I
in dairy cows: relationships among energy balance, body condition,
ovarian activity, and estrous behavior. J Dairy Sci, 73 (4): 929-937.
Stronge AJH, Sreenan JM, Diskin MG, Mee JF, Kenny DA, Morris DG
(2005) Post-insemination milk progesterone concentration and embryo
survival in dairy cows. Theriogenology, 64 (5): 1212-1224.
Tabandeh MR, Hosseini A, Saeb M, Kafi M, Saeb S (2010) Changes in the
gene expression of adiponectin and adiponectin receptors (AdipoR1
and AdipoR2) in ovarian follicular cells of dairy cow at different stages
of development. Theriogenology, 73 (5): 659-669.
Takemura Y, Osuga Y, Harada M, Hirata T, Koga K, Morimoto C, HirotaY,
Yoshino O, Yano T, Taketani Y (2005) Serum adiponectin concentrations
are decreased in women with endometriosis. Hum Reprod, 20
(12): 3510-3513.
Taylor VJ, Cheng ZPGA, Pushpakumara PGA, Wathes DC, Beever DE
(2004) Relationships between the plasma concentrations of insulin-
like growth factor-I in dairy cows and their fertility and milk yield.
Vet Rec, 155 (19): 583-588.
Wen JP, Lv WS, Yang J, Nie AF, Cheng XB, Yang Y, Ge Y, Li XY, Ning
G (2008) Globular adiponectin inhibits GnRH secretion from GT1-
hypothalamic GnRH neurons by induction of hyperpolarization of
membrane potential. Biochem Biophys Res Commun, 371 (4): 756-
Zulu VC, Nakao T, Sawamukai Y (2002) Insulin-like growth factor-I as a
possible hormonal mediator of nutritional regulation of reproduction
in cattle. J Vet Med Sci, 64 (8): 657-665.
Τα περισσότερο διαβασμένα άρθρα του ίδιου συγγραφέα(s)