Complicated corneal ulceration in cats: diagnosis and treatment outcomes of 80 cases (2014-2018)


Keywords:
ophthalmology cat ulcer perforation corneal surgery
KM ALI
AA MOSTAFA
S SOLIMAN
Abstract
The study describes the most common clinical and endoscopic findings associated with complicated corneal ulcers in cats and evaluates the short-term outcomes after surgical interventions. Eighty client-owned cats of different breeds with corneal ulcers were included. Cats were clinically evaluated to initially determine corneal abnormalities. Endoscopic examination of the corneas was performed to determine anterior and posterior segments’ abnormalities. Non-healing superficial ulcer was treated by superficial keratectomy and deep stromal ulcers were treated using conjunctival flaps. Corneal sequestrum were treated by partial keratectomies and conjunctival flaps. Anterior synechiae were treated via peripheral iridectomy and separation of the adhesion between the iris and the inner cornea. Symblepharon were treated by removal of the adhered conjunctival membrane from the cornea. Unresponsive endophthalmitis was treated surgically by exenteration. Outcomes after surgical managements of selected corneal abnormalities were assessed clinically and endoscopically. Non-healing superficial ulcer, deep stromal ulcer with descemetocele, endophthalmitis, symblepharon, corneal sequestration and anterior synechiae with secondary glaucoma and corneal scarring were the recorded complications of corneal ulcer. FHV-1 was a common etiologic factor of corneal ulceration. Persistent corneal scars of varying shape and size developed in cats with deep stromal ulcer, anterior synechiae, and corneal sequestration. Domestic shorthaired and Persian cats were the most predisposed breeds to FHV-1 infection and subsequent corneal ulceration. Management of patients with corneal ulcer would prevent serious complications. No age or sex predisposition to complicated corneal ulceration in cats was noticed.
Article Details
  • Section
  • Research Articles
Downloads
Download data is not yet available.
References
Abd-Elhamid MA, Ali KM, and Mostafa AA (2014) Endoscopic evaluation for the anterior and posterior segment of the eye: a new and useful technique for diagnosis of glaucoma in dogs. Life Sci. J. 11:233-237.
Ali KM and Hassan MH (2020) Visual outcome evaluation of complicated perforating corneal injuries after surgical repair in 45 cats. Turk J Vet Anim Sci 44: 894-903.
Barachetti L, Giudice C, Mortellaro CM. (2010) Amniotic membrane transplantation for the treatment of feline corneal sequestrum: pilot study. Vet. Ophthalmol. 13:326-330.
Barros PS, Safatle AM, Godoy CA, Souza MS, Barros LF, and Brooks DE (2005) Amniotic membrane transplantation for the reconstruction of the ocular surface in three cases. Vet. Ophthalmol. 8: 189-192.
Bentley E (2005) Spontaneous chronic corneal epithelial defects in dogs: a review. J. Am. Anim. Hosp. Assoc. 41: 158-165.
Chavkin M, Riis R, and Scherlie P (1990) Management of a persistent corneal erosion in a Boxer dog. Cornell Vet. 80: 347-356.
Douet JY, Michel J, Regnier A. (2013) Degree and duration of corneal anesthesia after topical application of 0.4% oxybuprocaine hydrochloride ophthalmic solution in ophthalmically normal dogs. Am J Vet Res. 74:1321-1326.
Featherstone HJ, and Sansom J (2004) Feline corneal sequestra: a review of 64 cases (80 eyes) from 1993 to 2000. Vet. Ophthalmol. 7: 213-227.
Gelatt K, and Samuelson D (1982). Recurrent erosions and epithelial dystrophy in the Boxer dog. J. Am. Anim. Hosp. Assoc. 18: 453-460.
Gelatt KN, Brooks DE (2011) Surgery of the cornea and sclera. In: Veterinary Ophthalmic Surgery, 5th edn. (eds. Gelatt KN, Gelatt JP) Elsevier/Saunders, Oxford. 191- 236.
Goulle F. Use of porcine small intestinal submucosa for corneal reconstruction in dogs and cats: 106 cases (2012). J. Small Anim. Pract. 53:34-43.
Groth A, Contreras M, Kado-Fong H, et al., (2014) In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites. Vet. Ophthalmol, 17, pp. 268-274.
Hankanson NE, and Merideth RE (1987) Conjunctival pedicle grafting in the treatment of corneal ulcers in the dog and cat. J. Am. Anim. Hosp. Assoc. 23: 641-648.
Kirchhoff H (1985) Mollicutes der Hunde und Katzen. In: Infektionen durch Mycoplasmatales. (ed. Gylstorff I). Ferdinand Enke Verlag, Stuttgart, pp 425-447.
Kirschner S, Brazzell R, Stern M, and Baird L (1991) The use of topical epidermal growth factor for treatment of non-healing corneal erosions in dogs. J. Am. Anim. Hosp. Assoc. 27: 449-452.
Laguna F, Leiva M, Costa D, Lacerda R and Gimenez TP (2015) Corneal grafting for the treatment of feline corneal sequestrum: a retrospective study of 18 eyes (13 cats).Vet Ophthalmol;18:291-296.
Maggs D (2008) Cornea and sclera. In: Slatter’s fundamentals of veterinary ophthalmology. (eds. Maggs D, Miller P, Ofri R). 4thedn. Saunders-Elsevier, St. Louis, Missouri, pp 175-202.
Martin C, and Stiles J (1998) Ocular infections. In: Infectious diseases of the dog and cat. (ed. Greene CE). 2ndedn. Philadelphia: W.B. Saunders Company, pp 659-62.
Michau TM, Schwabenton B, Davidson MG, and Gilger BC (2003) Superficial, nonhealing corneal ulcers in horses: 23 cases (1989-2003). Vet. Ophthalmol. 6: 291-297.
Mohan RR, Sharma A, Netto MV, Sinha S, and Wilson SE (2005) Gene therapy in the cornea. Progress in Retinal and Eye Research 24: 537-559.
Nasisse MP, English RV, Tompkins MB, Guy JS, and Sussman W (1995) Immunologic, histologic, and virologic features of herpesvirus-induced stromal keratitis in cats. Am. J. Vet. Res. 56: 51-55.
Razin S, and Freundt EA (1984) Mycoplasmatales. In: Bergey’s Manual of Systematic Bacteriology. (eds. Krieg NR, Holt JG). 1stedn. Williams and Wilkins, Baltimore, pp 740-70.
Sandmeyer LS, Waldner CL, Bauer BS, Wen X, and Bienzle D (2010) Comparison of polymerase chain reaction tests for diagnosis of feline herpesvirus, Chlamydophila felis, and Mycoplasma spp. infection in cats with ocular disease in Canada. Canadian Vet. J. 6: 629-633.
Slatter D (2001) In: Fundamentals of veterinary ophthalmology. (ed. Kersey R). 3rded. Philadelphia: W. B. Saunders Company, pp 213-217 and 283-287.
Stiles J (2014) Ocular manifestations of feline viral diseases, The Veterinary Journal, 201, 2: 166-173.
Stiles J, and Townsend WM (2007) Feline ophthalmology. In: Veterinary Ophthalmology. (ed. Gelatt KN). 4thedn. Ames, IA, Blackwell Publishing, pp 1095-1164.
Stiles J, McDermott M, Bigsby D, Willis M, Martin C, Roberts W, and Greene C (1997) Use of nested polymerase chain reaction to identify feline herpesvirus in ocular tissue from clinically normal cats and cats with corneal sequestra or conjunctivitis. Am. J. Vet. Res. 58: 338-342.
Tandon A, Tovey JC, Sharma A, Gupta R, and Mohan RR (2010) Role of transforming growth factor Beta in corneal function, biology and pathology. Curr. Mol. Med. 10: 565-578.
Vanore M, Chahory S, Payen G, and Clerc B (2007) Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats. Vet. Ophthalmol. 10: 93-99.
Whitcher JP, Srinivasan M, and Upadhyay MP (2001) Corneal blindness: a global perspective. Bull World Health Organ 79: 214-221.
Wichayacoop T, Briksawan P, Tuntivanich P, and Yibchok-Anun S (2009) Anti-inflammatory effects of topical supernatant from human amniotic membrane cell culture on canine deep corneal ulcer after human amniotic membrane transplantation. Vet. Ophthalmol. 12: 28-35.
Wilkie DA, and Whittaker C (1997) Surgery of the cornea. Vet. Clin. North Am. Small Anim. Pract. 27: 1067-1107.