Gastrointestinal stromal tumor (GIST) in a female Terrier dog


Δημοσιευμένα: Jul 10, 2024
Ενημερώθηκε: 2024-07-10
Εκδόσεις:
2024-07-10 (2)
O Yavas
https://orcid.org/0000-0001-9811-9920
NY Gul Satar
AM Mutlu
U Canatan
EC Özfirat
A Akkos
MÖ Özyiğit
Περίληψη

In this case report, two intestinal masses compatible with gastrointestinal stromal tumor (GIST) is described in a nine-year-old female Terrier dog. The dog presented with complaints of anorexia and vomiting following the ingestion of food. Abdominal ultrasonography revealed two masses in the ventral aspect of the stomach and duodenum. The masses were 6.1×3.7×2.3 cm and 3.2×2×1.7 cm in size, and cut surfaces of the masses were grayish-white-yellow and had a solid appearance. The greater mass invaded the intestinal serosa and mucosa. Cut surfaces were grayish white – yellow and had a solid appearance. Following routine histopathological processing, masses were sectioned at 4 μm, stained with H&E, and immunohistochemically with anti-c-KIT (CD117) antibody. Microscopically, the tumor comprised cells with an oval vesicular nucleus, spindle-shaped eosinophilic cytoplasm and a prominent nucleolus. Mitotic activity was significantly increased (5-6 mitoses at ×400 magnification), and occasionally binucleated cells were observed. Large necrotic areas surrounded by inflammatory cells were noticed. Gastrointestinal stromal tumor is a neoplasm originating from intestinal Cajal cells. The tumor is mostly confused with leiomyoma and leiomyosarcoma; immunohistochemical demonstration of c-KIT is performed for differential diagnosis. 

Λεπτομέρειες άρθρου
  • Ενότητα
  • Case Report
Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Avci H, Yaygingul R, Gultekin M, Epikmen ET, Ural K et al (2012) Primary intestinal fibrosarcoma caused by intestinal perforation in a dog:
a case report. Veterinarni Medicina, 57, 314-319.
Bettini G, Morini M, Marcato PS (2003) Gastrointestinal spindle cell tumors of the dog: Histological and immunohistochemical study. Journal of Comparative Pathology, 129, 283-293.
Dailey DD, Ehrhart EJ, Dawn LD, Bass T, Powers BE (2015) DOG1 is a
sensitive and specific immunohistochemical marker for diagnosis of
canine gastrointestinal stromal tumors. Journal of Veterinary Diagnostic Investigation, 27, 268-277.
Elliott JW, Swinbourne F, Parry A, Baines L (2017) Successful treatment
of a metastatic, gastrointestinal stromal tumor in a dog with toceranib
phosphate (Palladia). Journal of Small Animal Practice, 58, 416-418.
Gamba CO, Silva JO, Campos LC, Bernardes VF, Damasceno KA et al
(2012) Differential diagnosis of canine gastrointestinal stromal tumor.
Acta Scientiae Veterinariae, 40, 1044. (in Portuguese with an abstract
in English)
Gillespie V, Baer K, Farrelly J, Craft D, Luong R (2011) Canine gastrointestinal stromal tumors: Immunohistochemical expression of CD34
and examination of prognostic indicators including proliferation
markers Ki67 and AgNOR. Veterinary Pathology, 48, 283-291.
Girard-Luc A, Reyes-Gomez E, Fontaine J-J, Lagadic M, Bernex F
(2010) Les tumeurs stromales gastro-intestinales du chien: état des
connaissances et rôle diagnostique du pathologist. Pratique médicale
et chirurgicale de l’animal de compagnie, 45, 19-25. (in French with
an abstract in English)
Guzel Cay T (2006) Clinical, histological, immunohistochemical properties of gastrointestinal stromal tumors; the relationship of these features with each other and prognosis criteria (in Turkish). PhD Thesis,
İstanbul Eğitim ve Araştırma Hastanesi Patoloji Bölümü, Istanbul,
Turkey.
Hanazono K, Fukumoto S, Hirayama K, Takashima K, Yamane Y et al
(2012) Predicting metastatic potential of gastrointestinal stromal tumors in dog by ultrasonography. Journal of Veterinary Medical Science, 74, 1477-1482.
Hayes S, Yuzbasiyan-Gurkan V, Gregory-Bryson E, Kiupel M (2013)
Classification of canine nonangiogenic, nonlymphogenic, gastrointestinal sarcomas based on microscopic, ımmunohistochemical, and
molecular characteristics. Veterinary Pathology, 50, 779-788.
Hobbs J, Sutherland-Smith J, Pennick D, Jennings S, Barber L et al (2015)
Ultrasonographic features of canine gastrointestinal stromal tumors
compared to other gastrointestinal spindle cell tumors. Veterinary Radiology&Ultrasound, 56, 432-438.
Kumagai K, Uchida K, Miyamoto T, Ushigusa T, Shinohara S et al (2003)
Three cases of canine gastrointestinal stromal tumors with multiple
differentiations and c-kit-expression. Journal of Veterinary Medical
Science, 65, 1119-1122.
LaRock RG, Ginn PE (1997) Imminohistochemical staining characteristics of canine gastrointestinal stromal tumors. Veterinary Pathology,
, 303-311.
Maxie MG (editors) (2016) Jubb, Kennedy, and Palmer’s Pathology of
Domestic Animals. 6th edition. 3251 Riverport Lane St. Louis, Missouri 63043
Meuten DJ (editors) (2002). Tumors in Domestic Animals. Elsevier 4th
ed. Ames, Iowa
Suwa A, Shimoda T (2017) Intestinal gastrointestinal stromal tumor in a
cat. Journal of Veterinary Medical Science, 79, 562-566
Τα περισσότερο διαβασμένα άρθρα του ίδιου συγγραφέα(s)