test Impact of Subclinical Ketosis on Mastitis and Milk Parameters in Early Lactation Brown Swiss Cows|Περιοδικό της Ελληνικής Κτηνιατρικής Εταιρείας

Impact of Subclinical Ketosis on Mastitis and Milk Parameters in Early Lactation Brown Swiss Cows

PDF (English)
Δημοσιευμένα: Nov 10, 2025
DOI: https://doi.org/10.12681/jhvms.39387
IU Payano
Facultad de Zootecnia, Universidad Nacional del Centro del Perú, Huancayo, box 12006, Junín, Perú
J Ninahuanca
Facultad de Zootecnia, Universidad Nacional del Centro del Perú, Huancayo, box 12006, Junín, Perú
https://orcid.org/0000-0002-0137-0631
CQ Eulogio
Facultad de Ciencias de la Salud, Universidad Peruana los Andes, box 12002, Junín, Perú
EA Gomez
Facultad de Ciencias de la Salud, Universidad Peruana los Andes, box 12002, Junín, Perú
LB Alonso
Facultad de Zootecnia, Universidad Nacional del Centro del Perú, Huancayo, box 12006, Junín, Perú
MF Guillen
Facultad de Zootecnia, Universidad Nacional del Centro del Perú, Huancayo, box 12006, Junín, Perú
JU Fermín
Facultad de Ciencias de la Salud, Universidad Peruana los Andes, box 12002, Junín, Perú
WG Condor
Facultad de Ciencias de la Salud, Universidad Peruana los Andes, box 12002, Junín, Perú
Περίληψη

The objective of this study was to determine beta-hydroxybutyrate (BHB) levels as an identifier of subclinical ketosis and its effect on milk parameters and mastitis in postpartum dairy cows raised under highland conditions. A total of 32 primiparous and 32 multiparous cows were evaluated to determine the proportion of cows with subclinical ketosis using a semi-quantitative milk test, as well as the presence of mastitis, glucose levels, body condition, milk yield, and milk parameters such as somatic cell count, milk fat, and protein content. Data were analyzed using ANOVA and contingency tests for categorical variables. The prevalence of subclinical ketosis was 56% in multiparous cows and 14% in primiparous cows. Subclinical ketosis significantly affected (p < 0.05) milk protein reduction, increased somatic cell counts, and higher milk fat content. Cows with subclinical ketosis showed subclinical mastitis rates of 9.3% in primiparous cows and 17% in multiparous cows. Glucose levels were significantly reduced (p < 0.05) in cows with ketosis, with a greater reduction observed in multiparous cows. Body condition scores were lower in cows with subclinical ketosis, especially during early lactation (p < 0.05). Conversely, milk production increased in cows with subclinical ketosis, particularly after the second week postpartum. The findings suggest a potential effect of beta-hydroxybutyrate concentrations on the occurrence of mastitis and certain milk parameters in Brown Swiss cows raised at high altitudes.

Λεπτομέρειες άρθρου
  • Ενότητα
  • Research Articles
Creative Commons License

Αυτή η εργασία είναι αδειοδοτημένη υπό το CC Αναφορά Δημιουργού – Μη Εμπορική Χρήση 4.0.

Οι συγγραφείς των άρθρων που δημοσιεύονται στο περιοδικό διατηρούν τα δικαιώματα πνευματικής ιδιοκτησίας επί των άρθρων τους, δίνοντας στο περιοδικό το δικαίωμα της πρώτης δημοσίευσης.

Άρθρα που δημοσιεύονται στο περιοδικό διατίθενται με άδεια Creative Commons 4.0 Non Commercial και σύμφωνα με την άδεια μπορούν να χρησιμοποιούνται ελεύθερα, με αναφορά στο/στη συγγραφέα και στην πρώτη δημοσίευση για μη κερδοσκοπικούς σκοπούς.

Οι συγγραφείς μπορούν να καταθέσουν το άρθρο σε ιδρυματικό ή άλλο αποθετήριο ή/και να το δημοσιεύσουν σε άλλη έκδοση, με υποχρεωτική την αναφορά πρώτης δημοσίευσης στο J Hellenic Vet Med Soc

Οι συγγραφείς ενθαρρύνονται να καταθέσουν σε αποθετήριο ή να δημοσιεύσουν την εργασία τους στο διαδίκτυο πριν ή κατά τη διαδικασία υποβολής και αξιολόγησής της.

Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Benedet A, Manuelian C, Zidi A, Penasa M, De Marchi M (2019). Invited
review: β-hydroxybutyrate concentration in blood and milk and
its associations with cow performance. Animal 13(8): 1676–1689.
Berge AC, Vertenten G (2014). A field study to determine the prevalence,
dairy herd management systems, and fresh cow clinical conditions
associated with ketosis in western European dairy herds. J Dairy
Sci 97, 2145–2154.
Brunner N, Groeger S, Raposo J, Rupert M, Bruckmaier J, Gross J
(2018). Prevalence of subclinical ketosis and production diseases
in dairy cows in Central and South America, Africa, Asia, Australia
and New Zealand, and Eastern Europe. Transl Anim Sci 3(1): 84–92.
Carhuas JN, Grados LAC, Payano IU, Garcia-Olarte E, Mauricio-Ramos
Y, Eulogio CQ, Mohamed MMH (2025). Counting sheep: human
experience vs. Yolo algorithm with drone to determine population.
Vet Integr Sci 23(2): 1-9.
Chandler TL, Pralle RS, Dόrea JRR, Poock SE, Oetzel GR, Fourdraine
RH, White HM (2018). Predicting hyperketonemia by logistic
and linear regression using test-day milk and performance
variables in early-lactation Holstein and Jersey cows. J Dairy Sci
: 2476–2491.
Estremadoyro LJG, Salome PH, Carhuas JN, Guzman SO, Tacza AA,
Guillen MAF, Garcia-Olarte E (2024). Effects of different seasons
on milk quality: A study on two cattle breeds in rainy and drought
contexts. World Vet J 14(2), 213-219.
Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G (1989). A
body condition scoring chart for Holstein dairy cows. J Dairy Sci
(1): 68-78.
Ford HR, Mitchell TM, Scull T, Benitez OJ, Strieder-Barboza C (2024).
The Effect of Subclinical Ketosis on the Peripheral Blood Mononuclear
Cell Inflammatory Response and Its Crosstalk with Depot-Specific
Preadipocyte Function in Dairy Cows. Animals 14(13): 1995.
Grummer RR, Carroll DJ (1991). Effects of dietary fat on metabolic
disorders and reproductive performance of dairy cattle. J Anim Sci
(9): 3838-3852.
Ha S, Kang S, Jeong M, Han M, Lee J, Chung H, Park J (2023). Characteristics
of Holstein cows predisposed to ketosis during the postpartum
transition period. Vet Med Sci 9(1): 307-314.
Holzhauer M, Valarcher JF (2024). Literature Review and Metanalysis
of Fatty Liver Syndrome in Dairy Cows and Evaluation of Reference
Values of Triacyl Glycerides in Liver and NEFA, BHB, Glucose
and Insulin in Serum. Curr Trends Intern Med 8: 213.
Koeck A, Jamrozik J, Schenkel FS, Moore RK, Lefebvre DM, Kelton
DF, Miglior F (2014). Genetic analysis of milk β hydroxybutyrate
and its association with fatto- protein ratio, body condition score,
clinical ketosis, and displaced abomasum in early first lactation of
Canadian Holsteins. J Dairy Sci 97: 7286–7292.
Moyes KM, Larsen T, Sørensen P, Ingvartsen KL (2014). Changes in
various metabolic parameters in blood and milk during experimental
Escherichia coli mastitis for primiparous Holstein dairy cows during
early lactation. J Anim Sci Biotechnol 5: 47.
De Jong, E., Rijpert-Duvivier, A., Veldman, H., Steeneveld, W., & Jorritsma,
R. (2023). Milk β-hydroxybutyrate metrics and its consequences
for surveillance of hyperketonaemia on commercial dairy
farms. Front Vet Sci 10: 1272162.
Renaud DL, Kelton DF, Duffield TF (2019). Short communication:
Validation of a test-day milk test for β-hydroxybutyrate for identifying
cows with hyperketonemia. J Dairy Sci 102: 1589–1593.
Roche JR, Berry DP, Lee JM, Macdonald KA, Boston RC (2007).
Describing the body condition score change between successive
calvings: a novel strategy generalizable to diverse cohorts. J Dairy
Sci 90: 4378-4396.
Santschi DE, Lacroix R, Durocher J, Duplessis M, Moore RK, Lefebvre
DM (2016). Prevalence of elevated milk β-hydroxybutyrate concentrations
in Holstein cows measured by Fourier-transform infrared
analysis in dairy herd improvement milk samples and association
with milk yield and components. J Dairy Sci 99: 9263–9270.
Seely CR, Bach KD, Barbano DM, McArt JAA (2021). Effect of hyperketonemia
on the diurnal patterns of energy-related blood metabolites
in early-lactation dairy cows. J Dairy Sci 104(1): 818-825.
Suthar VS., Canelas-Raposo J., Deniz A, Heuwieser W (2013). Prevalence
of subclinical ketosis and relationships with postpartum
diseases in European dairy cows. J Dairy Sci 96: 2925–2938.
Sundrum A (2015). Metabolic disorders in the transition period indicate
that the dairy cows’ ability to adapt is overstressed. Animals 5(4):
-1020.
Tatone EH, Duffield TF, LeBlanc SJ, Devries TJ, Gordon JL (2017).
Investigating the within-herd prevalence and risk factors for ketosis
in dairy cattle in Ontario as diagnosed by the test-day concentration
of β-hydroxybutyrate in milk. J Dairy Sci 100: 1308–1318.
Tufarelli V, Puvača N, Glamočić D, Pugliese G, Colonna MA (2024).
The most important metabolic diseases in dairy cattle during the
transition period. Animals 14(5): 816.
Themistokleous KS, Papadopoulos I, Panousis N, Zdragas A, Kiossis
E (2023). Colour Doppler study of blood flow in the portal vein
in relation to blood flow in the milk vein, milk yield and body
condition of dairy cows during dry period and lactation. Res Vet
Sci 162: 104955.
Unchupaico I., Ancco E, Fernández E, Olivera W, Quispe C (2021).
Efectos del estado energético y proteico sobre parámetros reproductivos
y presencia de cetosis subclínica en vacas Brown Swiss
posparto. Spermova 11(2): 132-136.
Garro CJ, Mian L, Cobos Roldán M (2014). Subclinical ketosis in
dairy cows: prevalence and risk factors in grazing production system.
Anim Physiol Anim Nutr 98(5): 838-844.
Gorden PJ, Timms LL (2015). Lactation. En: Reece, W.O. (Ed.), Dukes’
Physiology of Domestic Animals, 13th Ed. John Wiley & Sons, Inc,
Ames, Iowa 50010, EE. ISBN:978-1-118-50139-9.
Chaput C, Sirard MA (2020). Embryonic response to high beta-hydroxybutyrate
(BHB) levels in postpartum dairy cows. Domest Anim
Endocrinol 72: 106431.
Zhang F, Nan X, Wang H, Zhao Y, Guo Y, Xiong B (2020). Effects of
propylene glycol on negative energy balance of postpartum dairy
cows. Animals 10(9): 1526.