Effect of Some Immunomodulators Use Together with PPR Vaccine on Immune system in Morkaraman Sheep

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Published: Jul 9, 2023
Updated: 2023-07-09
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2023-07-09 (3)
DOI: https://doi.org/10.12681/jhvms.28070
Keywords:
Immune System Immunostimulant Peste Des Petitis Ruminant Vaccine.
Ö Aydın
Ataturk University
https://orcid.org/0000-0001-9444-1904
MS Aktaş
Ataturk University
Abstract

In this study, it was aimed to investigate the effects of vitamin C (Vit-C), vitamin D (Vit-D), levamisole (LMS), inactivated parapoxvirus ovis (iPPVO) and corynebacterium cutis lysate (CCL) on the immune system in Morkaraman sheep on which the peste des petitis ruminant (PPR) vaccine was administered. In the Group B (Vit-D + PPR vaccine), in terms of IgG, when compared 0th, 14th, 21st and 28th, the values of the day 7th were determined to be significantly higher (P<0.01). In comparison to overall evaluation based on groups of IgG assay, the Group C (LMS + PPR vaccine) value was determined to be significantly higher than the Group F (PPR vaccine), Group A (Vit-C + PPR vaccine), Group B and Group D (iPPVO + PPR vaccine) values (P<0.01). In terms of IgM, when days among groups are compared, the highest value was determined on the 7th day in the Group A and this value was determined to be significant according to the 7th day Group F, Group E (CCL + PPR vaccine) and Group D values (P<0.01). The application of LMS at the stated dose had positive effects on the immune system due to changes in both IgM and IgG values, and Vit-C application at the stated dose had a partially positive effect only due to changes in IgM value; the administration of Vit-D, iPPVO and CCL at the stated doses did not have any positive effect on the immune system.

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Author Biographies
Ö Aydın, Ataturk University

Department of Veterinary Internal Medicine

MS Aktaş, Ataturk University

Department of Veterinary Internal Medicine

References
Abdullah KM, Basbugan Y (2020) The effect of used immunostimulating drugs with FMD vaccine on immunoglobulins in sheep. Van Vet J 31: 15-21.
Abejide O, Ayo JO, and Opoola E (2013) Effects of ascorbic acid on haematological parameters, excitability scores and live weights in yankasa sheep starved of feed and water. J Amin Prod Res 25: 1-9.
Ametaj BN, Beitz DC, Reinhardt TA, Nonnecke BJ (1996) 1,25-Dihydroxyvitamin D3 inhibits secretion of interferon-γ by mitogen- and antigen-stimulated bovine mononuclear leukocytes. Vet Immunol Immunopathol 52: 77-90.
Bilandžić N, Mitak M, Šimić B (2010) Levamisole increases leukocyte count and immunoglobulin levels in young boars. Slov Vet Res 47: 13-19.
Bilgehan H (1993) Temel Mikrobiyoloji ve Bağışıklık Bilimi. Barış Fakülteler Kitabevi, İzmir.
Blair L, Cummins KA (1984) Effect of dietary ascorbic acid on blood immunoglobulin concentration in dairy calves. J Dairy Sci 67: 138-139.
Boes M (2000) Role of natural and immune IgM antibodies in immune responses. Mol Immunol 37: 1141-1149.
Bourne FJ, Newby TJ, Evans P, Morgan K (1978) The immune requirements of the newborn pig and calf. Ann Rech Vet 9: 239-244.
Carr AC, Maggini S (2017) Vitamin C and Immune Function. Nutrients 9: 1.
Cummins KA, Brunner CJ (1991) Effect of calf housing on plasma ascorbate and endocrine and immune function. J Dairy Sci 74: 1582-1588.
Daha MR (2011) Grand challenges in molecular innate immunity. Front Immunol 2: 16.
Dik B, Dik I, Bahcivan E, Avci O (2016) Corynebacterium cutis lysate Treatment can increase the efficacies of PPR Vaccine. J Interferon Cytokine Res 36: 599-606.
Diker S (2005) İmmunoloji. 2nd ed, Medisan Yayınevi, Ankara: pp 47.
Er A, Corum O, Dik B, Bahcivan E, Eser H, Yazar E (2015) Koyunlara Corynebacterium cutis lizatı uygulamasının serum sitokin düzeylerine etkisinin belirlenmesi. Eurasian J Vet Sci 31: 209-213.
Fine PE, Sterne JA, Ponnighaus JM, Rees RJ (1994) Delayed-type hypersensitivity, mycobacterial vaccines and protective immunity. Lancet 344: 1245-1249.
Gasque P (2004) Complement: a unique innate immune sensor for danger signals. Mol Immunol 41: 1089-1098.
Gokce G, Irmak K, Sural E, Uzlu E (1997) Koyun çiçeğinde immunmodülatörlerin sağaltıcı ve koruyucu etkileri üzerinde klinik gözlemler. II. koyun çiçeğinin sağaltımı ve korunmasında pind-orf (baypamun) kullanımı. Kaskas Univ Vet Fak Derg 3: 217-221.
Greggs W (2013) Studies of feline leukemia virus drug susceptibility and antiviral mechanism of action. Dissertation thesis, University of Minnesota, Minnesota, pp 1-107.
Gulyaz V, Sarac F, Cokcaliskan C, Satir E, Sareyyupoglu B, Arslan A, Uzar S, Karakaya M, Kara O, Oztap G (2020) J Anim Health Prod 8: 19-26.
Halpern B, Fray A, Crepin Y, Platica O, Lorinet AM, Rabourdin A, Sparros L, Isac R. (1973) Corynebacterium parvum, a potent immunostimulant in experimental infectious and in malignancies. In: Immunopotentiation. Associated Scientific Publishers, Amsterdam: pp 217-236.
Hesta M, Ottermans C, Krammer-Lukas S, Zentek J, Hellweg P, Buyse J, Janssens GP (2009) The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters. J Anim Physiol Anim Nutr (Berl) 93: 26-34.
Huijskens MJ, Walczak M, Koller N, Briede JJ, Senden-Gijsbers BL, Schnijderberg MC, Bos GM, Germeraad WT (2014) Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells. J Leukoc Biol 96: 1165-1175.
Jariwalla RJ, Harakeh S (1996) Antiviral and immunmodulatory activities of ascorbic acid. In: Ascorbic Acid: Biochemistry and Biomedical Cell Biology. Plenum Press, New York: pp 215-231.
Konowalchuk JD, Rieger AM, Kiemele MD, Ayres DC, Barreda DR (2013) Modulation of weanling pig cellular immunity in response to diet supplementation with 25-hydroxyvitamin D(3). Vet Immunol Immunopathol 155: 57-66.
Levy R, Shriker O, Porath A, Riesenberg K, Schlaeffer F (1996) Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. J Infect Dis 173: 1502-1505.
Mix E, Goertsches R, Zett UK (2006) Immunoglobulins--basic considerations. J Neurol 253 (Suppl 5): 9-17.
Mohamed E, Ibrahim E, Mohamed F (2013) Effect of administration of ultra-corn with bivalent foot and mouth disease oil vaccine in calves. Vet World 6: 486.
Pekmezci D, Pekmezci GZ, Guzel M, Cenesiz S, Gurler AT, Gokalp G (2014) Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis. Vet Rec 174: 556.
Perrie Y, Mohammed AR, Kirby DJ, McNeil SE, Bramwell VW (2008) Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens. Int J Pharm 364: 272-280.
Proksch AL, Unterer S, Truyen U, Hartmann K (2014) Efficacy of the paramunity inducer PIND-ORF in the treatment of canine parvovirus infection. Vet J 202: 340-347.
Rashid BM, Yuksek N (2019) The Effects of immunostimulants (zinc, levamisole, vitamin AD3E) use together with enterotoxaemia vaccine on immunoglobulins in sheep. Turkish J Vet Anim Sci 3: 57-65.
Reinhardt TA, Stabel JR, Goff JP (1999) 1,25-dihydroxyvitamin D3 enhances milk antibody titers to Escherichia coli J5 vaccine. J Dairy Sci 82: 1904-1909.
Rong C, Jia-qi W, Deng-pan BU, Hong-yang W, Da-gang LSi-wei Z, Lei J, Lin-Yun Z, Qiu-jiang L (2007) The effect of Vitamin D3 on the immunoglobulins and T cell subsets of peripheral blood in prepartum dairy cattle. Chin J Anim Nutr 19: 6.
Roth JA, Kaeberle ML (1985) In vivo effect of ascorbic acid on neutrophil function in healthy and dexamethasone-treated cattle. Am J Vet Res 46: 2434-2436.
Saat N, Yuksel M, Toraman ZA, Risvanli A (2016) The efficiency of Corynebacterium cutis lysate in cows with subclinical mastitis. Res Opin Anim Vet Sci 6: 108-110.
Schutze N, Raue R, Buttner M, Alber G (2009) Inactivated parapoxvirüs ovis activates canine blood phagocytes and T lymphocytes. Vet Microbiol 137: p. 260-267.
Schutze N, Raue R, Buttner M, Kohler G, McInnes CJ, Alber G (2010) Specific antibodies induced by inactivated parapoxvirus ovis potently enhance oxidative burst in canine blood polymorphonuclear leukocytes and monocytes. Vet Microbiol 140: 81-91.
Smith BS, Wright H (1985) Effect of parenteral vitamin D3 on plasma 25-hydroxyvitamin D3 concentration in sheep. Res Vet Sci 39: 59-61.
Stelletta C, Cuteri V, Bonizzi L, Frangipane di Regalbono A, Orsi F, Nisoli L, Lulla D, Morgante M (2004) Effect of levamisole administration on bluetongue vaccination in sheep. Vet Ital 40: 635-639.
Terzic S, Bilandzic N, Jemersic LLogomerac V, Cvetnic Z, Sandor K, Orsolic N, Valpotic I (2009) Immunoglobulins in Pigs Vaccinated with a Subunit E2 and an Attenuated C Strain Vaccine against Classical Swine Fever. Acta Veterinaria-Beograd 59: 489-501.
Tizard IR (2013) Veterinary Immunology. 9th ed, Elsevier Saunders, St. Louis: pp 166-167.
Tyler PJ, Cummins KA (2003) Effect of dietary ascorbyl-2-phosphate on immune function after transport to a feeding facility. J Dairy Sci 86: 622-629.
Undiandeye UJ, Oderinde BS, El-Yuguda A, Baba SS (2014) Immunostimulatory effect of levamisole on the immune response of goats to peste des petits ruminants (PPR) vaccination. World J Vaccines 4: 88-95.
Vink A, Coulie PG, Wauters P, Nordan RP, Van Snick J (1988) B cell growth and differentiation activity of interleukin-HP1 and related murine plasmacytoma growth factors. Synergy with interleukin 1. Eur J Immunol 18: 607-612.
von Rosenberg SJ, Weber GM, Erhardt A, Holler U, Wehr UA, Rambeck WA (2016) Tolerance evaluation of overdosed dietary levels of 25-hydroxyvitamin D3 in growing piglets. J Anim Physiol Anim Nutr (Berl) 100: 371-380.
Yilmaz O, Kasikci G (2013) Factors affecting colostrum quality of ewes and immunostimulation. Turkish J Vet Anim Sci 37: 390-394.
Yilmaz, OTKasikci, G, Gunduz MC (2011) Benefits of pregnant sheep immunostimulation with corynebacterium cutis on post-partum and early newborn’s life IgG levels, stillbirth rate and lamb’s weight. Small Rum Res 97: 146-151.
Yue Y, Hymoller L, Jensen SK, Lauridsen C (2018) Effect of vitamin D treatments on plasma metabolism and immune parameters of healthy dairy cows. Arch Anim Nutr 72: 205-220.
Zhao J, Li D, Piao X, Yang W, Wang F (2002) Effects of vitamin C supplementation on performance, iron status and immune function of weaned piglets. Arch Anim Nutr 56: 33-40.