A Comprehensive Review of Herbal and Synthetic Therapeutics in Managing Viral Diseases in Fish Health
Δημοσιευμένα:
May 24, 2025
Ενημερώθηκε:
2025-05-24
Εκδόσεις:
2025-05-24 (2)
Περίληψη
Disease outbreaks are the main cause of financial loss in aquaculture, resulting in an estimated annual loss of over $10 billion. Fish viral diseases pose a continuous risk to the production of aquaculture, and despite advancements in the industry, approximately 10% of cultured aquatic animals succumb to infectious diseases, resulting in significant losses. Preventing and treating viral diseases in animals and humans is one of the most difficult tasks due to the varying effectiveness of vaccines, interferons, and other medications. While salmonids have been successful in controlling significant bacterial diseases through the use of antibiotics and vaccines, vaccines for viral diseases often prove to be ineffective. Standard antibiotics are not effective in preventing or treating viral diseases in fish. The risk of infectious disease outbreaks, including viral infections, increases with monoculture, as in the case of terrestrial agriculture. Unfortunately, the treatment of viral diseases often fails, highlighting the need for more research to find effective drugs and vaccines to manage viral diseases. This article explores the potential of using herbal and synthetic drugs to combat viral diseases that impact fish populations.
Λεπτομέρειες άρθρου
- Πώς να δημιουργήσετε Αναφορές
-
Hasani, S., Nofouzi, K., Meshkiniy, S., Enferadi, A., Jalilzadeh, N., & Ravvaz, A. (2025). A Comprehensive Review of Herbal and Synthetic Therapeutics in Managing Viral Diseases in Fish Health. Περιοδικό της Ελληνικής Κτηνιατρικής Εταιρείας, 76(1), 8805–8818. https://doi.org/10.12681/jhvms.37804 (Original work published 19 Απρίλιος 2025)
- Τεύχος
- Τόμ. 76 Αρ. 1 (2025)
- Ενότητα
- Review Articles
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Αναφορές
Adamek, M., Matras, M., Dawson, A., Piackova, V., Gela, D., Kocour, M.,
et al. (2019). Type I interferon responses of common carp strains with
different levels of resistance to koi herpesvirus disease during infection
with CyHV-3 or SVCV. Fish Shellfish Immunol. 87: 809-819.
Adamek, M., Rakus, K., Chyb, J., Brogden, G., Huebner, A., Irnazarow,
I., & Steinhagen, D. (2012). Interferon type I responses to virus infections
in carp cells: In vitro studies on Cyprinid herpesvirus 3 and
Rhabdovirus carpio infections. Fish Shellfish Immunol. 33(3): 482-
Adams, A. (2019). Progress, challenges and opportunities in fish vaccine
development. Fish Shellfish Immunol. 90: 210-214.
Ahne, W., Bjorklund, H., Essbauer, S., Fijan, N., Kurath, G., & Winton,
J. (2002). Spring viremia of carp (SVC). Dis. Aquat. Organ. 52(3):
-272.
Aich, N., Paul, A., Choudhury, T. G., & Saha, H. (2022). Tilapia lake virus
(TiLV) disease: Current status of understanding. Aquac. Fish. 7(1):
-17.
Assefa, A., & Abunna, F. (2018). Maintenance of fish health in aquaculture:
review of epidemiological approaches for prevention and control
of infectious disease of fish. Vet. Med. Int. 2018.
Ballesteros, N. A., Alonso, M., Saint-Jean, S. R., & Perez-Prieto, S. I.
(2015). An oral DNA vaccine against infectious haematopoietic necrosis
virus (IHNV) encapsulated in alginate microspheres induces
dose-dependent immune responses and significant protection in rainbow
trout (Oncorrhynchus mykiss). Fish Shellfish Immunol. 45(2):
-888.
Bandín, I., & Souto, S. (2020). Betanodavirus and VER disease: a 30-year
research review. J. Pathog. 9(2): 106.
Barros, M. M., Falcon, D. R., de Oliveira Orsi, R., Pezzato, L. E., Fernandes
Jr, A. C., Guimarães, I. G., et al. (2014). Non-specific immune
parameters and physiological response of Nile tilapia fed β-glucan
and vitamin C for different periods and submitted to stress and bacterial
challenge. Fish shellfish immunol. 39(2): 188-195.
Bøgwald, J., & Dalmo, R. A. (2019). Review on Immersion Vaccines for
Fish: An Update 2019. Microorganisms. 7(12).
Bomstein, Y., Marder, J., & JOWERS, T. P. (2020). Herbal extracts for
treatment of herpesvirus infections: Google Patents.
Borrego, J. J., Valverde, E. J., Labella, A. M., & Castro, D. (2017). Lymphocystis
disease virus: its importance in aquaculture. Rev. Aquac.
(2): 179-193.
Breyer, K. E., Getchell, R. G., Cornwell, E. R., Wooster, G. A., Ketola,
H. G., & Bowser, P. R. (2015). Efficacy of an extract from garlic,
Allium sativum, against infection with the furunculosis bacterium,
Aeromonas salmonicida, in rainbow trout, Oncorhynchus mykiss.
JWAS. 46(3): 273-282.
Bricknell, I., & Dalmo, R. A. (2005). The use of immunostimulants in fish
larval aquaculture. Fish Shellfish Immunol. 19(5): 457-472.
Buck, C. C., & Loh, P. C. (1985). In vitro effect of acyclovir and other
antiherpetic compounds on the replication of channel catfish virus.
Antiviral res. 5(5): 269-280.
Cain, K. (2022). The many challenges of disease management in aquaculture.
JWAS. 53(6).
Caruffo, M., Maturana, C., Kambalapally, S., Larenas, J., & Tobar, J. A.
(2016). Protective oral vaccination against infectious salmon anaemia
virus in Salmo salar. Fish shellfish immunol. 54: 54-59.
Cho, S. Y., Kim, H. J., Lan, N. T., Han, H.-J., Lee, D.-C., Hwang, J. Y.,
et al. (2017). Oral vaccination through voluntary consumption of the
convict grouper Epinephelus septemfasciatus with yeast producing
the capsid protein of red-spotted grouper nervous necrosis virus. Vet.
Microbiol. 204: 159-164.
Collet, B. (2014). Innate immune responses of salmonid fish to viral infections.
DCI. 43(2): 160-173.
Covarrubias, C. E., Rivera, T. A., Soto, C. A., Deeks, T., & Kalergis, A.
M. (2022). Current GMP standards for the production of vaccines and
antibodies: An overview. FPUBH. 10: 1021905.
Dadar, M., Dhama, K., Vakharia, V. N., Hoseinifar, S. H., Karthik, K., Tiwari,
R., et al. (2017). Advances in aquaculture vaccines against fish
pathogens: global status and current trends. Rev. Fish. Sci. Aquac.
(3): 184-217.
Das, B. K., Ellis, A. E., & Collet, B. (2009). Induction and persistence
of Mx protein in tissues, blood and plasma of Atlantic salmon parr,
Salmo salar, injected with poly I: C. Fish Shellfish Immunol. 26(1):
-48.
Dishon, A., Ashoulin, O., Scott Weber III, E., & Kotler, M. (2014). Vaccination
against koi herpesvirus disease. Fish vac. 321-333.
Dopazo, C. P. (2020). The infectious pancreatic necrosis virus (IPNV)
and its virulence determinants: What is known and what should be
known. J. Pathog. 9(2): 94.
Du, Y., Hu, X., Miao, L., & Chen, J. (2022). Current status and development
prospects of aquatic vaccines. FPUBH. 13: 1040336.
Elnagar, M. A., Khalil, R. H., Talaat, T. S., & Sherif, A. H. (2024). A blend
of chitosan-vitamin C and vitamin E nanoparticles robust the immunosuppressed-
status in Nile tilapia treated with salt. BMC Vet. Res.
(1): 331.
Emmenegger, E., & Kurath, G. (2008). DNA vaccine protects ornamental
koi (Cyprinus carpio koi) against North American spring viremia of
carp virus. Vaccine. 26(50): 6415-6421.
Eyngor, M., Zamostiano, R., Kembou Tsofack, J. E., Berkowitz, A., Bercovier,
H., Tinman, S., et al. (2014). Identification of a novel RNA
virus lethal to tilapia. J. Clin. Microbiol. 52(12): 4137-4146.
Falk, K., Namork, E., Rimstad, E., Mjaaland, S., & Dannevig, B. H.
(1997). Characterization of infectious salmon anemia virus, an orthomyxo-
like virus isolated from Atlantic salmon (Salmo salar L.).Virol.
J. 71(12): 9016-9023.
Ferguson, H. W., Kabuusu, R., Beltran, S., Reyes, E., Lince, J., & del
Pozo, J. (2014). Syncytial hepatitis of farmed tilapia, Oreochromis
niloticus (L.): a case report. J. Fish. Dis. 37(6): 583-589.
Fernandez-Trujillo, A., Ferro, P., Garcia-Rosado, E., Infante, C., Alonso,
M., Bejar, J., et al. (2008). Poly I: C induces Mx transcription and
promotes an antiviral state against sole aquabirnavirus in the flatfish
Senegalese sole (Solea senegalensis Kaup). Fish Shellfish immunol.
(3): 279-285.
González-Fernández, C., & Cuesta, A. (2022). Nanoplastics increase fish
susceptibility to nodavirus infection and reduce antiviral immune responses.
Int. J. Mol. Sci. 23(3): 1483.
Gye, H. J., Oh, M.-J., & Nishizawa, T. (2018). Lack of nervous necrosis
virus (NNV) neutralizing antibodies in convalescent sevenband
grouper Hyporthodus septemfasciatus after NNV infection. Vaccine.
(14): 1863-1870.
Hadfield, C. A. (2021). Viral diseases. Clinical Guide to Fish Medicine,
-430.
Hanson, L., Dishon, A., & Kotler, M. (2011). Herpesviruses that infect
fish. Viruses. 3(11): 2160-2191.
Huang, X., Ma, Y., Wang, Y., Niu, C., Liu, Z., Yao, X., et al. (2021). Oral
probiotic vaccine expressing koi herpesvirus (KHV) ORF81 protein
delivered by chitosan-alginate capsules is a promising strategy
for mass oral vaccination of carps against KHV infection. Virol. J.
(12): 10.1128/jvi. 00415-00421.
Ibrahim, R. E., Amer, S. A., Farroh, K. Y., Al-Gabri, N. A., Ahmed, A. I.,
El-Araby, D. A., & Ahmed, S. A. A. (2021). The effects of chitosan-vitamin
C nanocomposite supplementation on the growth performance,
antioxidant status, immune response, and disease resistance of Nile
tilapia (Oreochromis niloticus) fingerlings. Aquac. 534: 736269.
Irshath, A. A., Rajan, A. P., Vimal, S., Prabhakaran, V. S., & Ganesan,
R. (2023). Bacterial Pathogenesis in Various Fish Diseases: Recent
Advances and Specific Challenges in Vaccine Development. Vaccines
(Basel). 11(2).
Islam, S. I., Mou, M. J., & Sanjida, S. (2022). Application of reverse vaccinology
for designing of an mRNA vaccine against re-emerging marine
birnavirus affecting fish species. IMU. 30: 100948.
Isshiki, T., Nagano, T., Kanehira, K., & Suzuki, S. (2004). Distribution
of marine birnavirus in cultured marine fish species from Kagawa Prefecture, Japan. J. Fish Dis. 27(2): 89-98.
Jaemwimol, P., Sirikanchana, K., Tattiyapong, P., Mongkolsuk, S., &
Surachetpong, W. (2019). Virucidal effects of common disinfectants
against tilapia lake virus. J. Fish Dis. 42(10): 1383-1389.
Jansen, M. D., Dong, H. T., & Mohan, C. V. (2019). Tilapia lake virus:
a threat to the global tilapia industry? Rev. Aquac. 11(3): 725-739.
Jensen, I., Albuquerque, A., Sommer, A.-I., & Robertsen, B. (2002). Effect
of poly I: C on the expression of Mx proteins and resistance against
infection by infectious salmon anaemia virus in Atlantic salmon. Fish
shellfish immunol. 13(4): 311-326.
Jung, M.-H., Jung, S.-J., & Kim, T. (2022). Saponin and chitosan-based
oral vaccine against viral haemorrhagic septicaemia virus (VHSV)
provides protective immunity in olive flounder (Paralichthys olivaceus).
Fish shellfish immunol. 126: 336-346.
Kembou-Ringert, J. E., Steinhagen, D., Readman, J., Daly, J. M., &
Adamek, M. (2023). Tilapia Lake Virus Vaccine Development: A Review
on the Recent Advances. Vaccines (Basel). 11(2).
Kibenge, F. S., Godoy, M. G., Fast, M., Workenhe, S., & Kibenge, M. J.
(2012). Countermeasures against viral diseases of farmed fish. Antiviral
res. 95(3): 257-281.
Kim, H. J., Oseko, N., Nishizawa, T., & Yoshimizu, M. (2009). Protection
of rainbow trout from infectious hematopoietic necrosis (IHN) by injection
of infectious pancreatic necrosis virus (IPNV) or Poly (I: C).
Dis. Aquat. Organ. 83(2): 105-113.
Kimura, T., Suzuki, S., & Yoshimizu, M. (1983). In vitro antiviral effect
of 9-(2-hydroxyethoxymethyl) guanine on the fish herpesvirus, Oncorhynchus
masou virus (OMV). Antiviral Res. 3(2): 93-101.
Kotob, M. H., Menanteau-Ledouble, S., Kumar, G., Abdelzaher, M., &
El-Matbouli, M. (2017). The impact of co-infections on fish: a review.
Vet. Res. 47(1): 1-12.
Labella, A. M., Leiva-Rebollo, R., Alejo, A., Castro, D., & Borrego, J.
J. (2019). Lymphocystis disease virus (LCDV-Sa), polyomavirus 1
(SaPyV1) and papillomavirus 1 (SaPV1) in samples of Mediterranean
gilthead seabream. Dis. Aquat. Organ. 132(2): 151-156.
Lee, J. Y., & Gao, Y. (2012). Review of the application of garlic, Allium
sativum, in aquaculture. JWAS. 43(4): 447-458.
Lee, Y., Kim, N., Roh, H., Park, J., Kim, M., Lee, J., & Kim, D.-H.
(2022). Hepcidin-1 in olive flounder (Paralichthys olivaceus): Gene
expression, antimicrobial and therapeutic effects of synthetic peptides
against bacterial and viral infections. Aquac. 560: 738480.
Li, C., Cao, Y., Kohei, F., Hao, H., Peng, G., Cheng, C., & Ye, J. (2022).
Nano-bubble hydrogen water: An effective therapeutic agent against
inflammation related disease caused by viral infection in zebrafish
model. Virol. Sin. 37(2): 277-283.
Li, P., Huang, S., Xiao, S., Xu, Y., Wei, X., Xiao, J., et al. (2022). Antiviral
Activities of Green Tea Components against Grouper Iridovirus Infection
In Vitro and In Vivo. Viruses. 14(6).
Li, Y., Zheng, S., Wang, Q., Bergmann, S. M., Zeng, W., Wang, Y., et al.
(2017). Detection of koi herpesvirus (KHV) using a monoclonal antibody
against Cyprinus carpio IgM. Arch. Virol. 162(8): 2381-2385.
Lieke, T., Meinelt, T., Hoseinifar, S. H., Pan, B., Straus, D. L., & Steinberg,
C. E. (2020). Sustainable aquaculture requires environmental‐
friendly treatment strategies for fish diseases. Rev. Aquac. 12(2):
-965.
Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., & Sung, Y. Y. (2020).
Proteomic profiling of zebrafish challenged by spring viremia of carp
virus provides insight into skin antiviral response. Zebrafish. 17(2):
-103.
Lockhart, K., Bowden, T., & Ellis, a., AE. (2004). Poly I: C-induced Mx
responses in Atlantic salmon parr, post-smolts and growers. Fish
shellfish immunol. 17(3): 245-254.
Lulijwa, R., Alfaro, A. C., Merien, F., Meyer, J., & Young, T. (2019). Advances
in salmonid fish immunology: A review of methods and techniques
for lymphoid tissue and peripheral blood leucocyte isolation
and application. Fish shellfish immunol. 95: 44-80.
Ma, J., Bruce, T. J., Jones, E. M., & Cain, K. D. (2019). A Review of Fish
Vaccine Development Strategies: Conventional Methods and Modern
Biotechnological Approaches. Microorganisms. 7(11).
Magnadottir, B. (2010). Immunological control of fish diseases. Mar. biotechnol.
: 361-379.
Manchanayake, T., Salleh, A., Amal, M. N. A., Yasin, I. S. M., & Zamri-
Saad, M. (2023). Pathology and pathogenesis of Vibrio infection in
fish: A review. Aquac. Rep. 28: 101459.
Meena, D., Das, P., Kumar, S., Mandal, S., Prusty, A., Singh, S., et al.
(2013). Beta-glucan: an ideal immunostimulant in aquaculture (a review).
Fish Physiol. Biochem. 39: 431-457.
Mishra, S., Seshagiri, B., Rathod, R., Sahoo, S. N., Choudhary, P., Patel,
S., et al. (2023). Recent advances in fish disease diagnosis, therapeutics,
and vaccine development. Frontiers in Aquaculture Biotechnology.
-145.
Mugimba, K. K., Byarugaba, D. K., Mutoloki, S., Evensen, Ø., & Munang’andu,
H. M. (2021). Challenges and Solutions to Viral Diseases
of Finfish in Marine Aquaculture. J. Pathog. 10(6).
Ninawe, A., Hameed, A. S., & Selvin, J. (2017). Advancements in diagnosis
and control measures of viral pathogens in aquaculture: an Indian
perspective. Aquac. Int. 25: 251-264.
Nishizawa, T., Furuhashi, M., Nagai, T., Nakai, T., & Muroga, K. (1997).
Genomic classification of fish nodaviruses by molecular phylogenetic
analysis of the coat protein gene. Appl. Environ. Microbiol. 63(4):
-1636.
O’Connor, M. R., Farver, T. B., Malm, K. V., Yun, S. C., Marty, G. D.,
Salonius, K., et al. (2014). Protective immunity of a modified-live cyprinid
herpesvirus 3 vaccine in koi (Cyprinus carpio koi) 13 months
after vaccination. Am. J. Vet. Res. 75(10): 905-911.
Ortega-Villaizan, M. d. M., Chico, V., & Perez, L. (2022). Fish innate
immune response to viral infection—An overview of five major antiviral
genes. Viruses. 14(7): 1546.
Ouyang, G., Liao, Q., Fan, S., Cai, X., Wang, J., Liu, X., & Xiao, W.
(2023). Zebrafish Mavs is essential for antiviral innate immunity. J.
Immunol. 210(9): 1314-1323.
Pagowski, V. A., Mordecai, G. J., Miller, K. M., Schulze, A. D., Kaukinen,
K. H., Ming, T. J., et al. (2019). Distribution and phylogeny of
erythrocytic necrosis virus (ENV) in salmon suggests marine origin.
Viruses. 11(4): 358.
Patel, S., & Nerland, A. H. (2014). Vaccination against diseases caused by
Betanodavirus. Fish Vac. 341-351.
Pereiro, P., Costa, M., Díaz-Rosales, P., Dios, S., Figueras, A., & Novoa,
B. (2014). The first characterization of two type I interferons in turbot
(Scophthalmus maximus) reveals their differential role, expression
pattern and gene induction. Dev. Comp. Immunol. 45(2): 233-244.
Pereiro, P., Figueras, A., & Novoa, B. (2021). Compilation of antiviral
treatments and strategies to fight fish viruses. Rev. Aquac. 13(3):
-1254.
Perveen, S., Yang, L., Xie, X., Han, X., Gao, Q., Wang, J., et al. (2022).
Vitamin C elicits the activation of immunological responses in swimming
crab (Portunus trituberculatus) hemocytes against Mesanophrys
sp. Aquaculture. 547: 737447.
Rahmati-Holasoo, H., Ahmadivand, S., Shokrpoor, S., & El-Matbouli, M.
(2020). Detection of Carp pox virus (CyHV-1) from koi (Cyprinus
carpio L.) in Iran; clinico-pathological and molecular characterization.
Mol. Cell. Probes. 54: 101668.
Rajanbabu, V., & Chen, J.-Y. (2011). Applications of antimicrobial peptides
from fish and perspectives for the future. Peptides. 32(2): 415-
Rao, Y., & Su, J. (2015). Insights into the antiviral immunity against grass
carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp. J.
Immunol. Res. 2015.
Reichert, M., Bergmann, S. M., Hwang, J., Buchholz, R., & Lindenberger,
C. (2017). Antiviral activity of exopolysaccharides from Arthrospira
platensis against koi herpesvirus. J Fish Dis. 40(10): 1441-1450.
Reyes-López, F. E., Romeo, J. S., Vallejos-Vidal, E., Reyes-Cerpa, S.,
Sandino, A. M., Tort, L., et al. (2015). Differential immune gene expression
profiles in susceptible and resistant full-sibling families of
Atlantic salmon (Salmo salar) challenged with infectious pancreatic
necrosis virus (IPNV). Dev. Comp. Immunol. 53(1): 210-221.
Romero, J. F., Gardner, I. A., Saksida, S., McKenzie, P., Garver, K., Price,
D., & Thakur, K. (2022). Simulated waterborne transmission of infectious
hematopoietic necrosis virus among farmed salmon populations
in British Columbia, Canada following a hypothetical virus incursion.
Aquac. 548: 737658.
Sanjida, S., Mou, M. J., Islam, S. I., & SAROWER-E-MAHFUJ, M.
(2022). An In-silico approaches for identification of potential natural antiviral drug candidates against Erythrocytic necrosis virus (Iridovirus)
by targeting Major capsid protein: a Quantum mechanics calculations
approach. Int. J. Life Sci. Biotechnol. 5(3): 294-315.
Shahsavani, D., Baghshani, H., & Alishahi, E. (2011). Efficacy of allicin
in decreasing lead (Pb) accumulation in selected tissues of lead-exposed
common carp (Cyprinus carpio). Biol. Trace. Elem. Res. 142:
-580.
Soto, E., Yun, S., & Surachetpong, W. (2019). Susceptibility of Tilapia
Lake Virus to buffered Povidone-iodine complex and chlorine.
Aquac. 512: 734342.
Thammatorn, W., Rawiwan, P., & Surachetpong, W. (2019). Minimal risk
of tilapia lake virus transmission via frozen tilapia fillets. J. Fish Dis.
(1): 3-9.
Vimal, S., Farook, M., Madan, N., Abdul Majeed, S., Nambi, K., Taju,
G., et al. (2016). Development, distribution and expression of a DNA
vaccine against nodavirus in Asian Seabass, Lates calcarifier (Bloch,
. Aquac. Res. 47(4): 1209-1220.
Waiyamitra, P., Zoral, M. A., Saengtienchai, A., Luengnaruemitchai, A.,
Decamp, O., Gorgoglione, B., & Surachetpong, W. (2020). Probiotics
modulate tilapia resistance and immune response against tilapia lake
virus infection. J. Pathog. 9(11): 919.
Weber, E. S., Malm, K. V., Yun, S. C., Campbell, L. A., Kass, P. H., Marty,
G. D., et al. (2014). Efficacy and safety of a modified-live cyprinid
herpesvirus 3 vaccine in koi (Cyprinus carpio koi) for prevention of
koi herpesvirus disease. Am. J. Vet. Res. 75(10): 899-904.
Xia, S., Wang, H., Hong, X., Lu, J., Xu, D., Jiang, Y., & Lu, L. (2018).
Identification and characterization of a type I interferon induced by
cyprinid herpesvirus 2 infection in crucian carp Carassius auratus
gibelio. Fish Shellfish Immunol. 76: 35-40.
Yildirim, A., Duran, G. G., Duran, N., Jenedi, K., Bolgul, B. S., Miraloglu,
M., & Muz, M. (2016). Antiviral activity of hatay propolis against
replication of herpes simplex virus type 1 and type 2. Med. Sci.
Monit: Med Sci Monit. 22: 422.
Yu, X. B., Hao, K., Ling, F., Zhu, B., & Wang, G. X. (2020). In vivo
antiviral efficacy of moroxydine hydrochloride against grass carp reovirus
and the drug safety assessment. Aquac. Res. 51(4): 1592-1601.
Zeng, W., Wang, Y., Hu, H., Wang, Q., Bergmann, S. M., Wang, Y., et
al. (2021). Cell culture-derived tilapia lake virus-inactivated vaccine
containing montanide adjuvant provides high protection against viral
challenge for tilapia. Vaccines. 9(2): 86.
Zhou, X.-y., Lu, L.-f., Li, Z.-c., Zhang, C., Chen, D.-d., & Li, S. (2021).
Temperature effects on SVCV propagation and the related IFN response
in zebrafish. Aquac. 533: 736084.
Zhou, Y., Qiu, T.-X., Hu, Y., Ji, J., Liu, L., & Chen, J. (2022). Evaluation
on the antiviral activity of artemisinin against rhabdovirus infection
in common carp. Aquac. 559: 738410.
Zhu, X., Hao, R., Zhang, J., Tian, C., Hong, Y., Zhu, C., & Li, G. (2022).
Improved growth performance, digestive ability, antioxidant capacity,
immunity and Vibrio harveyi resistance in coral trout (Plectropomus
leopardus) with dietary vitamin C. Aquac. Rep. 24: 101111.
