Thymoma associated exfoliative dermatitis in a rabbit with hepatic cirrhosis


A. Komnenou
J. Androulakis-Kess
R. Farmaki
D. Psalla
V. Psychas
Resumen

A 6.5-year-old, male, non-castrated pet rabbit was presented with generalized exfoliative dermatitis, depression and anorexia. Skin laboratory examinations were negative for ectoparasites, bacteria and fungi whereas thoracic radiography revealed a large mediastinal mass. Complete blood and biochemical examinations did not show anything abnormal. Thymoma was suspected and therapeutic options were discussed but the owner declined. Supportive and symptomatic therapy was of no avail and severe deterioration of systemic symptoms necessitated euthanasia. Necropsy revealed a whitish-gray mass on the anterior and lower part of the mediastinum and pale voluminous liver. Histopathology confirmed the presence of thymoma and the hypothesis of thymoma-associated exfoliative dermatitis along with hepatic cirrhosis.

Article Details
  • Sección
  • Case Report
Descargas
Los datos de descargas todavía no están disponibles.
Citas
Bentley PJ, Grubb BR (1991) Effects of a zinc-deficient diet on tissue zinc concentration in rabbits. J of Anim Science 69:4876–4882.
Boyce S, Harper J (2002) Paraneoplastic dermatoses. Dermatol Clin 20:523–532.
Carpenter JL, Holzworth J (1982) Thymoma in 11 cats. J Am Vet Med Assoc 181:248–251
Clippinger TL, Bennett RA, Alleman AR, et al (1998) Removal of a thymoma via median sternotomy in a rabbit with recurrent appendicular neurofibrosarcoma. J Am Vet Med Assoc 213: 1140–1143.
Florizoone K (2005) Thymoma-associated exfoliative dermatitis in a rabbit. Vet Derm 16:281–284.
Florizoone K, Van der Luer R, Van den Ingh T (2007) Symetrical alopecia, scaling and hepatitis in a rabbit. Vet Dermatol 18:161-163.
Gross TL, Ihrke PJ., Walder EJ, et al (2005) Interface diseases of the dermal–epidermal junction. In: Skin diseases of the dog and the cat. Clinical and histopathologic diagnosis. 2nd ed, Blackwell Science Ltd, Oxford: pp 68-70.
Harkness JE, Turner PV, Woude SV, et al (2010) Clinical Procedures. In: Harkness and Wagner ́s Biology and medicine of rabbits and rodents. 5th ed, Willey-Blackwell, Ames, pp: 118–121.
Harvey RG (1990) Demodex cuniculi in dwarf rabbits (Oryctolagus cuniculus). J Small Anim Pract 31:204–207.
Heatley JJ, Smith AN (2004) Spontaneous neoplasms of lagomorphs. Vet Clin North Am Exot Anim Pract 7(3) (Sept):561–577,v.
Isasi I, Muñoz G, Ramírez G, et al (2012) Dermatitis exfoliativa y alopecia asociada a hepatitis en un conejo (Hepatitis-associated exfoliative dermatitis and alopecia in a rabbit). Clin Vet Peq Anim 32(3):175–179.
Jassies–Van Der Lee A, Van Zeeland Y, Kik M, et al (2009) Successful treatment of sebaceous adenitis in a rabbit with ciclosporin and triglycerides. Vet Dermatol 20:67–71.
Jenkins JR (2001) Skin disorders of the rabbit. Vet Clin North Am Exotic Anim Pract 4:543–563.
Kesler KA, Wright CD, Loehrer PJ (2004) Thymoma: Current medical and surgical management. Semin Neurol 24:63–73.
Künzel F, Hittmair KM, Hassan J, et al (2012) Thymomas in Rabbits: Clinical Evaluation, Diagnosis, and Treatment. J Am Anim Hosp Assoc 48:2(Mar/Apr):97–104.
Miller WH, Griffin CE, Campbell KL (2013) Dermatoses of Exotic Small Mammals. In: Muller and Kirk’s Small Animal Dermatology. 7th ed, Elsevier/Mosby, St. Louis: pp 869–870.
Morrisey JK, McEntee M (2005) Therapeutic options for thymoma in the rabbit. Sem Avian Exotic Pet Med 14(3):175–181.
Mueller RS (2014) Canine demodicosis. In: Kirk’s Current Veterinary Therapy XV. 15th ed, Elsevier/Saunders, Philadelphia: pp 432–434, 2014.
Paterson S (2006) Skin Diseases and Treatment of Rabbits. In: Skin Diseases of Exotic Pets. Blackwell Science Ltd, Oxford: pp 302.
Rosenthal K, Hoefer H, Quesenberry K, et al (1995) Question cause of hypercalcemia in a rabbit. J Am Vet Med Assoc 206(11):1675–1677.
Rostaher-Prélaud A, Jassies-van der Lee A, Mueller RS, et al (2013) Presumptive paraneoplastic exfoliative dermatitis in four domestic rabbits. Vet Rec 172:155.
Rottenberg S, von Tscharner C, Roosje PJ (2004) Thymoma-associated exfoliative dermatitis in cats. Vet Path 41:429–433.
Scott, DW (2010) Erythema multiforme in dogs and cats http://veterinarycalendar.dvm360.com/erythema-multiforme-dogsand-cats-proceedings [Accessed 20 July 2017]
Snook TS, White SD, Hawkins MG, et al (2013) Skin diseases in pet rabbits: a retrospective study of 334 cases seen at the University of California at Davis, USA (1984–2004). Vet Derm 24:613-e148.
Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Derm 14:279–296.
Vennen KM, Mitchell MA (2009) Hematology/Chemistry Panels in Rabbits. In: Manual of Exotic Pet Practice, Saunders/Elsevier, St. Louis: pp 381-382.
Weisbroth SH (1994) Neoplastic Diseases. In: The Biology of the Laboratory Rabbit. 2nd ed, Academic Press, San Diego: pp 259–292.
White SD, Carpenter JL, Moore FM, et al (1987) Generalised demodicosis associated with diabetes mellitus in two cats. J Am Vet Med Assoc 191:448-450.
White SD, Campbell T, Logan A, et al (2000) Lymphoma with cutaneous involvement in three domestic rabbits (Oryctolagus cuniculis). Vet Dermatol 11:61–67.
Zitz JC, Birchard SJ, Couto GC, et al (2008) Results of excision of thymoma in cats and dogs: 20 cases (1984–2005). J Am Vet Med Assoc 232:1186–1192.
Artículos más leídos del mismo autor/a